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CC BY 4.0 · Glob Med Genet 2023; 10(04): 339-344
DOI: 10.1055/s-0043-1777072
Review Article

The Epigenetic Regulation of Quiescent in Stem Cells

Mehran Radak
1   Department of Biology, School of Sciences, Razi University, Baq-e-Abrisham, Kermanshah, Islamic Republic of Iran
,
Hossein Fallahi
1   Department of Biology, School of Sciences, Razi University, Baq-e-Abrisham, Kermanshah, Islamic Republic of Iran
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Abstract

This review article discusses the epigenetic regulation of quiescent stem cells. Quiescent stem cells are a rare population of stem cells that remain in a state of cell cycle arrest until activated to proliferate and differentiate. The molecular signature of quiescent stem cells is characterized by unique epigenetic modifications, including histone modifications and deoxyribonucleic acid (DNA) methylation. These modifications play critical roles in regulating stem cell behavior, including maintenance of quiescence, proliferation, and differentiation. The article specifically focuses on the role of histone modifications and DNA methylation in quiescent stem cells, and how these modifications can be dynamically regulated by environmental cues. The future perspectives of quiescent stem cell research are also discussed, including their potential for tissue repair and regeneration, their role in aging and age-related diseases, and their implications for cancer research. Overall, this review provides a comprehensive overview of the epigenetic regulation of quiescent stem cells and highlights the potential of this research for the development of new therapies in regenerative medicine, aging research, and cancer biology.

Keywords

epigenetic regulation - quiescent stem cells - histone modifications - DNA methylation - molecular signature - environmental cues - tissue repair


Publication History

Article published online:
22 November 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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