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CC BY 4.0 · Glob Med Genet 2023; 10(04): 382-387
DOI: 10.1055/s-0043-1777087
Review Article

Mesenchymal Stem Cells Applications in Alzheimer's Disease

Oluwatosin Debola Oyebode
1   Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus
,
Pınar Tulay
1   Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus
2   DESAM Research Institute, Near East University, Nicosia, Cyprus
3   Center of Excellence, Genetics and Cancer Diagnosis-Research Center, Near East University, Nicosia, Cyprus
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that advances gradually and primarily impacts the hippocampus region of the brain. It is defined by a deterioration in cognitive function as well as an observable loss of memory retention. One of the major characteristics of AD is the impairment of neural generation, resulting in the depletion of neurons and synaptic connections within the nervous system. It is unfortunate to say that, at present, no definitive cure is available for AD, and no medication is effective in halting the progression of neurodegeneration associated with it. Nevertheless, it is crucial to highlight that progress has been achieved in addressing the troubling symptoms of AD. The Food and Drug Administration has granted approval for two categories of medications designed to alleviate these symptoms. The scientific community has been inspired by these advancements to investigate alternative therapeutic options, with an emphasis on stem cell therapy in particular. The main focus of this review will be on the potential for the use of a variety of mesenchymal stem cells as a treatment for AD.

Keywords

Alzheimer's disease (AD) - mesenchymal stem cells - Aβ plaques - microglia - neuroinflammation


Publication History

Article published online:
11 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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