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CC BY 4.0 · Arq Neuropsiquiatr 2023; 81(12): 1077-1083
DOI: 10.1055/s-0043-1777105
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Sjogren's syndrome: a neurological perspective

Síndrome de Sjogren: uma perspectiva neurológica
Orlando Grazianni Povoas Barsottini 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Setor de Neurologia Geral e Ataxias, São Paulo SP, Brazil.
,
Marianna Pinheiro Moraes de Moraes 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Setor de Neurologia Geral e Ataxias, São Paulo SP, Brazil.
,
Pedro Henrique Almeida Fraiman 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, Setor de Neurologia Geral e Ataxias, São Paulo SP, Brazil.
,
Victor Hugo Rocha Marussi 
2   Hospital Beneficência Portuguesa, Setor de Neurorradiologia, São Paulo SP, Brazil.
,
Alexandre Wagner Silva de Souza 
3   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina, Divisão de Reumatologia, São Paulo SP, Brazil.
4   Sociedade Brasileira de Reumatologia, Comissão de Vasculites, São Paulo SP, Brazil.
,
Pedro Braga Neto 
5   Universidade Federal do Ceará, Departamento de Medicina Clínica, Divisão de Neurologia, Fortaleza CE, Brazil.
6   Universidade do Estado do Ceará, Centro de Ciências da Saúde, Fortaleza CE, Brazil.
,
Mariana Spitz 
7   Universidade do Estado do Rio de Janeiro, Serviço de Neurologia, Rio de Janeiro RJ, Brazil.
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Abstract

Sjogren's syndrome (SS) is a complex autoimmune disease characterized by lymphocytic infiltration of salivary and lacrimal glands, resulting in sicca symptoms. Additionally, SS presents with neurological manifestations that significantly impact the nervous system. This review aims to provide a comprehensive overview of the neurological aspects of SSj, covering both the peripheral and central nervous system involvement, while emphasizing diagnosis, treatment, and prognosis.

Resumo

A síndrome de Sjogren (SS) é uma doença autoimune complexa caracterizada pela infiltração linfocítica das glândulas salivares e lacrimais, resultando em sintomas sicca. Além disso, a SS apresenta manifestações neurológicas que afetam significativamente o sistema nervoso. Esta revisão tem como objetivo fornecer uma visão abrangente dos aspectos neurológicos da SSj, abordando tanto o envolvimento do sistema nervoso periférico quanto do central, com ênfase no diagnóstico, tratamento e prognóstico.

Keywords

Sjogren's Syndrome - Autoimmune Diseases of the Nervous System

Palavras-chave

Síndrome de Sjogren - Doenças Autoimunes do Sistema Nervoso

Authors' Contributions

OGPB, MPMM, PHAF, VHRM, AWSS, PBN, MS: contributed equally with the manuscript by helping to review and select papers; writing the first draft and the final versions of manuscript, and reviewing the manuscript.




Publication History

Received: 18 August 2023

Accepted: 20 October 2023

Article published online:
29 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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