Clin Colon Rectal Surg 2024; 37(06): 359-367
DOI: 10.1055/s-0043-1777439
Review Article

Diverticulitis: A Review of Current and Emerging Practice-Changing Evidence

Sonia Wu
1   Department of Digestive Surgery, Centre Hospitalier Universitaire de Montréal, Montreal, QC, Canada
,
Maher Al Khaldi
1   Department of Digestive Surgery, Centre Hospitalier Universitaire de Montréal, Montreal, QC, Canada
,
Carole S. Richard
1   Department of Digestive Surgery, Centre Hospitalier Universitaire de Montréal, Montreal, QC, Canada
,
François Dagbert
1   Department of Digestive Surgery, Centre Hospitalier Universitaire de Montréal, Montreal, QC, Canada
› Institutsangaben

Abstract

Acute diverticulitis represents a common colorectal emergency seen in the Western world. Over time, management of this condition has evolved. This review aims to highlight recent evidence and update current recommendations. Notable evidence has emerged in certain aspects of diverticulitis. This includes disease pathogenesis, as emerging data suggest a potentially greater role for the microbiome and genetic predisposition than previously thought. Acute management has also seen major shifts, where traditional antibiotic treatment may no longer be necessary for acute uncomplicated diverticulitis. Following successful medical management of acute diverticulitis, indications for elective sigmoidectomy have decreased. The benefit of emergency surgery remains for peritonitis, sepsis, obstruction, and acute diverticulitis in certain immunocompromised patients. Routine colonoscopy, once recommended after all acute diverticulitis episodes, has been shown to be beneficial for cancer exclusion in a distinct patient population. Despite advances in research, certain entities remain poorly understood, such as smoldering diverticulitis and symptomatic uncomplicated diverticular disease. As research in the field expands, paradigm shifts will shape our understanding of diverticulitis, influencing how clinicians approach management and educate patients.



Publikationsverlauf

Artikel online veröffentlicht:
13. Dezember 2023

© 2023. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Peery AF, Crockett SD, Murphy CC. et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology 2019; 156 (01) 254-272
  • 2 Tursi A, Scarpignato C, Strate LL. et al. Colonic diverticular disease. Nat Rev Dis Primers 2020; 6 (01) 20
  • 3 Peery AF, Sandler RS, Ahnen DJ. et al. Constipation and a low-fiber diet are not associated with diverticulosis. Clin Gastroenterol Hepatol 2013; 11 (12) 1622-1627
  • 4 Strate LL, Liu YL, Syngal S, Aldoori WH, Giovannucci EL. Nut, corn, and popcorn consumption and the incidence of diverticular disease. JAMA 2008; 300 (08) 907-914
  • 5 Maguire LH, Handelman SK, Du X, Chen Y, Pers TH, Speliotes EK. Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease. Nat Genet 2018; 50 (10) 1359-1365
  • 6 Barbara G, Scaioli E, Barbaro MR. et al. Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease. Gut 2017; 66 (07) 1252-1261
  • 7 Feuerstein JD, Falchuk KR. Diverticulosis and diverticulitis. Mayo Clin Proc 2016; 91 (08) 1094-1104
  • 8 Peery AF, Keku TO, Martin CF. et al. Distribution and characteristics of colonic diverticula in a United States screening population. Clin Gastroenterol Hepatol 2016; 14 (07) 980-985.e1
  • 9 Reichert MC, Lammert F. The genetic epidemiology of diverticulosis and diverticular disease: emerging evidence. United European Gastroenterol J 2015; 3 (05) 409-418
  • 10 Peery AF, Keku TO, Galanko JA, Sandler RS. Sex and race disparities in diverticulosis prevalence. Clin Gastroenterol Hepatol 2020; 18 (09) 1980-1986
  • 11 Sköldberg F, Granlund J, Discacciati A, Hjern F, Schmidt PT, Olén O. Incidence and lifetime risk of hospitalization and surgery for diverticular disease. Br J Surg 2019; 106 (07) 930-939
  • 12 Etzioni DA, Mack TM, Beart Jr RW, Kaiser AM. Diverticulitis in the United States: 1998-2005: changing patterns of disease and treatment. Ann Surg 2009; 249 (02) 210-217
  • 13 Nguyen GC, Sam J, Anand N. Epidemiological trends and geographic variation in hospital admissions for diverticulitis in the United States. World J Gastroenterol 2011; 17 (12) 1600-1605
  • 14 Francis NK, Sylla P, Abou-Khalil M. et al. EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice. Surg Endosc 2019; 33 (09) 2726-2741
  • 15 Liu PH, Cao Y, Keeley BR. et al. Adherence to a healthy lifestyle is associated with a lower risk of diverticulitis among men. Am J Gastroenterol 2017; 112 (12) 1868-1876
  • 16 Kvasnovsky CL, Papagrigoriadis S, Bjarnason I. Increased diverticular complications with nonsteriodal anti-inflammatory drugs and other medications: a systematic review and meta-analysis. Colorectal Dis 2014; 16 (06) O189-O196
  • 17 Stollman N, Smalley W, Hirano I. AGA Institute Clinical Guidelines Committee. American Gastroenterological Association Institute guideline on the management of acute diverticulitis. Gastroenterology 2015; 149 (07) 1944-1949
  • 18 Hall J, Hardiman K, Lee S. et al; Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the treatment of left-sided colonic diverticulitis. Dis Colon Rectum 2020; 63 (06) 728-747
  • 19 Galgano SJ, McNamara MM, Peterson CM. et al; Expert Panel on Gastrointestinal Imaging. ACR Appropriateness Criteria® left lower quadrant pain-suspected diverticulitis. J Am Coll Radiol 2019; 16 (5S): S141-S149
  • 20 Laméris W, van Randen A, Bipat S, Bossuyt PMM, Boermeester MA, Stoker J. Graded compression ultrasonography and computed tomography in acute colonic diverticulitis: meta-analysis of test accuracy. Eur Radiol 2008; 18 (11) 2498-2511
  • 21 Sher ME, Agachan F, Bortul M, Nogueras JJ, Weiss EG, Wexner SD. Laparoscopic surgery for diverticulitis. Surg Endosc 1997; 11 (03) 264-267
  • 22 Hinchey EJ, Schaal PG, Richards GK. Treatment of perforated diverticular disease of the colon. Adv Surg 1978; 12: 85-109
  • 23 Chabok A, Påhlman L, Hjern F, Haapaniemi S, Smedh K. AVOD Study Group. Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg 2012; 99 (04) 532-539
  • 24 Daniels L, Ünlü Ç, de Korte N. et al; Dutch Diverticular Disease (3D) Collaborative Study Group. Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis. Br J Surg 2017; 104 (01) 52-61
  • 25 Dichman ML, Rosenstock SJ, Shabanzadeh DM. Antibiotics for uncomplicated diverticulitis. Cochrane Database Syst Rev 2022; 6 (06) CD009092
  • 26 Desai M, Fathallah J, Nutalapati V, Saligram S. Antibiotics versus no antibiotics for acute uncomplicated diverticulitis: a systematic review and meta-analysis. Dis Colon Rectum 2019; 62 (08) 1005-1012
  • 27 Emile SH, Elfeki H, Sakr A, Shalaby M. Management of acute uncomplicated diverticulitis without antibiotics: a systematic review, meta-analysis, and meta-regression of predictors of treatment failure. Tech Coloproctol 2018; 22 (07) 499-509
  • 28 Bolkenstein HE, Draaisma WA, van de Wall B, Consten E, Broeders I. Treatment of acute uncomplicated diverticulitis without antibiotics: risk factors for treatment failure. Int J Colorectal Dis 2018; 33 (07) 863-869
  • 29 Al-Khamis A, Abou Khalil J, Demian M. et al. Sigmoid colectomy for acute diverticulitis in immunosuppressed vs immunocompetent patients: outcomes from the ACS-NSQIP database. Dis Colon Rectum 2016; 59 (02) 101-119
  • 30 Springer JE, Doumouras AG, Nair S, Eskicioglu C, Forbes S. Does imaging before percutaneous drain removal affect rates of intra-abdominal abscess recurrence?. J Surg Res 2018; 232: 408-414
  • 31 Acuna SA, Dossa F, Baxter NN. The end of the Hartmann's era for perforated diverticulitis. Lancet Gastroenterol Hepatol 2019; 4 (08) 573-575
  • 32 Binda GA, Karas JR, Serventi A. et al; Study Group on Diverticulitis. Primary anastomosis vs nonrestorative resection for perforated diverticulitis with peritonitis: a prematurely terminated randomized controlled trial. Colorectal Dis 2012; 14 (11) 1403-1410
  • 33 Acuna SA, Wood T, Chesney TR. et al. Operative strategies for perforated diverticulitis: a systematic review and meta-analysis. Dis Colon Rectum 2018; 61 (12) 1442-1453
  • 34 Lee JM, Bai P Chang J, El Hechi M. et al. Hartmann's procedure vs primary anastomosis with diverting loop ileostomy for acute diverticulitis: nationwide analysis of 2,729 emergency surgery patients. J Am Coll Surg 2019; 229 (01) 48-55
  • 35 Vermeulen J, Gosselink MP, Busschbach JJV, Lange JF. Avoiding or reversing Hartmann's procedure provides improved quality of life after perforated diverticulitis. J Gastrointest Surg 2010; 14 (04) 651-657
  • 36 Thaler K, Baig MK, Berho M. et al. Determinants of recurrence after sigmoid resection for uncomplicated diverticulitis. Dis Colon Rectum 2003; 46 (03) 385-388
  • 37 Cross KLR, Rees JR, Soulsby RHR, Dixon AR. Primary anastomosis without colonic lavage for the obstructed left colon. Ann R Coll Surg Engl 2008; 90 (04) 302-304
  • 38 Letarte F, Hallet J, Drolet S. et al. Laparoscopic emergency surgery for diverticular disease that failed medical treatment: a valuable option? Results of a retrospective comparative cohort study. Dis Colon Rectum 2013; 56 (12) 1395-1402
  • 39 Vennix S, Musters GD, Mulder IM. et al; Ladies trial colloborators. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 2015; 386 (10000): 1269-1277
  • 40 Azhar N, Johanssen A, Sundström T. et al; SCANDIV Study Group. Laparoscopic lavage vs primary resection for acute perforated diverticulitis: long-term outcomes from the Scandinavian Diverticulitis (SCANDIV) randomized clinical trial. JAMA Surg 2021; 156 (02) 121-127
  • 41 Angenete E, Thornell A, Burcharth J. et al. Laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results from the randomized controlled trial DILALA. Ann Surg 2016; 263 (01) 117-122
  • 42 Vennix S, van Dieren S, Opmeer BC, Lange JF, Bemelman WA. Cost analysis of laparoscopic lavage compared with sigmoid resection for perforated diverticulitis in the Ladies trial. Br J Surg 2017; 104 (01) 62-68
  • 43 Hoek VT, Edomskis PP, Stark PW. et al; LADIES trial collaborators. Laparoscopic peritoneal lavage versus sigmoidectomy for perforated diverticulitis with purulent peritonitis: three-year follow-up of the randomised LOLA trial. Surg Endosc 2022; 36 (10) 7764-7774
  • 44 Penna M, Markar SR, Mackenzie H, Hompes R, Cunningham C. Laparoscopic lavage versus primary resection for acute perforated diverticulitis: review and meta-analysis. In: Annals of Surgery. Ann Surg 2018; 267 (02) 252-258
  • 45 Meyer J, Orci LA, Combescure C. et al. Risk of colorectal cancer in patients with acute diverticulitis: a systematic review and meta-analysis of observational studies. Clin Gastroenterol Hepatol 2019; 17 (08) 1448-1456.e17
  • 46 Regenbogen SE, Hardiman KM, Hendren S, Morris AM. Surgery for diverticulitis in the 21st century: a systematic review. JAMA Surg 2014; 149 (03) 292-303
  • 47 Chapman JR, Dozois EJ, Wolff BG, Gullerud RE, Larson DR. Diverticulitis: a progressive disease? Do multiple recurrences predict less favorable outcomes?. Ann Surg 2006; 243 (06) 876-830 , discussion 880–883
  • 48 Rose J, Parina RP, Faiz O, Chang DC, Talamini MA. Long-term outcomes after initial presentation of diverticulitis. Ann Surg 2015; 262 (06) 1046-1053
  • 49 Aquina CT, Becerra AZ, Xu Z. et al. Population-based study of outcomes following an initial acute diverticular abscess. Br J Surg 2019; 106 (04) 467-476
  • 50 Li D, De Mestral C, Baxter NN. et al. Risk of readmission and emergency surgery following nonoperative management of colonic diverticulitis: a population-based analysis. Ann Surg 2014; 260 (03) 423-430 , discussion 430–431
  • 51 Gaertner WB, Willis DJ, Madoff RD. et al. Percutaneous drainage of colonic diverticular abscess: is colon resection necessary?. Dis Colon Rectum 2013; 56 (05) 622-626
  • 52 Sartelli M, Weber DG, Kluger Y. et al. 2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting. World J Emerg Surg 2020; 15 (01) 32
  • 53 Biondo S, Borao JL, Kreisler E. et al. Recurrence and virulence of colonic diverticulitis in immunocompromised patients. Am J Surg 2012; 204 (02) 172-179
  • 54 Santos A, Mentula P, Pinta T. et al. Comparing laparoscopic elective sigmoid resection with conservative treatment in improving quality of life of patients with diverticulitis: the Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) randomized clinical trial. JAMA Surg 2021; 156 (02) 129-136
  • 55 Santos A, Mentula P, Pinta T. et al. Quality-of-life and recurrence outcomes following laparoscopic elective sigmoid resection vs conservative treatment following diverticulitis: prespecified 2-year analysis of the LASER randomized clinical trial. JAMA Surg 2023; 158 (06) 593-601
  • 56 Horgan AF, McConnell EJ, Wolff BG, The S, Paterson C. Atypical diverticular disease: surgical results. Dis Colon Rectum 2001; 44 (09) 1315-1318
  • 57 Mari GM, Crippa J, Borroni G. et al; on behalf of the AIMS Academy Clinical Research Network. Symptomatic uncomplicated diverticular disease and incidence of unexpected abscess during sigmoidectomy: a multicenter prospective observational study. Dig Surg 2020; 37 (03) 199-204
  • 58 Carter F, Alsayb M, Marshall JK, Yuan Y. Mesalamine (5-ASA) for the prevention of recurrent diverticulitis. Cochrane Database Syst Rev 2017; 10 (10) CD009839
  • 59 Picchio M, Elisei W, Tursi A. Mesalazine to treat symptomatic uncomplicated diverticular disease and to prevent acute diverticulitis occurrence. A systematic review with meta-analysis of randomized, placebo-controlled trials. J Gastrointestin Liver Dis 2018; 27 (03) 291-297