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DOI: 10.1055/s-0043-1778034
Anterior Spinal Artery Syndrome in a 14-Year-Old Boy

Abstract
Acute flaccid paralysis caused by anterior spinal artery syndrome (ASAS) is rare in children. It typically manifests as bilateral loss of motor function, pain, and temperature sensation below the level of occlusion, with relatively little impairment in proprioception and vibration sense. We present such a case in a 14-year-old child who presented with a sudden onset of neck pain followed by the typical symptoms of ASAS with impaired breathing due to the height of the lesion, which was found in the magnetic resonance imaging examination at the level of C1–5. An initially suspected thrombogenic cause proved inapplicable. Ultimately, despite extensive diagnosis, as in most cases of ASAS in children, the cause remains unclear.
Keywords
acute flaccid paralysis - spinal cord infarction - anterior spinal artery syndrome - neck pain - thrombolysisAuthors' contribution
F.W. and P.G. concepted and drafted the manuscript, and reviewed and revised the manuscript. M.H., M.S., and S.M. had all significant parts of the conception of the manuscript, and they all critically reviewed it and revised it for important intellectual content.
All authors approved the final manuscript as submitted and agreed to be responsible for all aspects of the work.
Publikationsverlauf
Eingereicht: 07. August 2023
Angenommen: 18. November 2023
Artikel online veröffentlicht:
29. Dezember 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Georg Thieme Verlag KG
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References
- 1 Vargas MI, Gariani J, Sztajzel R. et al. Spinal cord ischemia: practical imaging tips, pearls, and pitfalls. AJNR Am J Neuroradiol 2015; 36 (05) 825-830
- 2 Sandoval JI. Anterior Spinal Artery Syndrome. StatPearls - NCBI Bookshelf. Accessed November 3, 2023 at: https://www.ncbi.nlm.nih.gov/books/NBK560731/ Published July 24, 2023.
- 3 Marx A. Differential diagnosis of acute flaccid paralysis and its role in poliomyelitis surveillance. Accessed November 3, 2023 at: https://www.semanticscholar.org/paper/Differential-diagnosis-of-acute-flaccid-paralysis-Marx-Glass/29d136feecd64f1b9b3b476bd1fd80633a95075b Published 2000.
- 4 Singhi SC, Sankhyan N, Shah R, Singhi P. Approach to a child with acute flaccid paralysis. Indian J Pediatr 2012; 79 (10) 1351-1357
- 5 Santana JA. Ventral Cord Syndrome. StatPearls - NCBI Bookshelf. Accessed November 3, 2023 at: https://www.ncbi.nlm.nih.gov/books/NBK541011/ Published August 14, 2023.
- 6 Klakeel M, Thompson J, Srinivasan R, McDonald F. Anterior spinal cord syndrome of unknown etiology. Proc Bayl Univ Med Cent 2015; 28 (01) 85-87
- 7 Morshid A, Jadiry HA, Chaudhry U, Raghuram K. Pediatric spinal cord infarction following a minor trauma: a case report. Spinal Cord Ser Cases 2020; 6 (01) 95
- 8 Pearl NA. Anterior Cord Syndrome. StatPearls - NCBI Bookshelf. Accessed November 3, 2023 at: https://www.ncbi.nlm.nih.gov/books/NBK559117/ Published August 22, 2022.
- 9 Weidauer S, Nichtweiss M, Lanfermann H, Zanella FE. Spinal cord infarction: MR imaging and clinical features in 16 cases. Neuroradiology 2002; 44 (10) 851-857
- 10 Ramineni KK, Kandraju SS, Jakkani RK, Alwala S. Imaging highlights of anterior spinal cord infarction: owl's eye sign. Curr J Neurol 2021; 20 (02) 118-119
- 11 Müller KI, Steffensen LH, Johnsen SH. Thrombolysis in anterior spinal artery syndrome. BMJ Case Rep 2012; bcr2012006862
- 12 Santillán A, Goldberg JL, Carnevale JA, Kirnaz S, Härtl R, Knopman J. Anterior spinal artery syndrome caused by thoracic disc herniation. J Clin Neurosci 2020; 77: 211-212
- 13 Novy J, Carruzzo A, Maeder P, Bogousslavsky J. Spinal cord ischemia: clinical and imaging patterns, pathogenesis, and outcomes in 27 patients. Arch Neurol 2006; 63 (08) 1113-1120
- 14 Nance JR, Golomb MR. Ischemic spinal cord infarction in children without vertebral fracture. Pediatr Neurol 2007; 36 (04) 209-216
- 15 Reisner A, Gary MF, Chern JJ, Grattan-Smith JD. Spinal cord infarction following minor trauma in children: fibrocartilaginous embolism as a putative cause. J Neurosurg Pediatr 2013; 11 (04) 445-450
- 16 Duignan SM, Hemingway CA. Paediatric acquired demyelinating syndromes. Paediatr Child Health 2019; 29 (11) 468-475
- 17 Hakimi KN, Massagli TL. Anterior spinal artery syndrome in two children with genetic thrombotic disorders. J Spinal Cord Med 2005; 28 (01) 69-73
- 18 Young G, Manco-Johnson M, Gill JC. et al. Clinical manifestations of the prothrombin G20210A mutation in children: a pediatric coagulation consortium study. J Thromb Haemost 2003; 1 (05) 958-962
- 19 Hasegawa M, Yamashita J, Yamashima T, Ikeda K, Fujishima Y, Yamazaki M. Spinal cord infarction associated with primary antiphospholipid syndrome in a young child. Case report. J Neurosurg 1993; 79 (03) 446-450
- 20 Almasanu BP, Owensby JR, Pavlakis SG, Edwards JH. Spinal cord infarction in meningitis: polygenic risk factors. Pediatr Neurol 2005; 32 (02) 124-126
- 21 Hagen EM, Rekand T, Grønning M, Faerestrand S. Kardiovaskulære følgetilstander etter ryggmargsskade. Tidsskr Nor Laegeforen 2012; 132 (09) 1115-1120
- 22 Pang D. Spinal cord injury without radiographic abnormality in children, 2 decades later. Neurosurgery 2004; 55 (06) 1325-1342 discussion 1342–1343
- 23 Chang CW, Donovan DJ, Liem LK. et al. Surfers' myelopathy: a case series of 19 novice surfers with nontraumatic myelopathy. Neurology 2012; 79 (22) 2171-2176
- 24 Davis GA, Klug GL. Acute-onset nontraumatic paraplegia in childhood: fibrocartilaginous embolism or acute myelitis?. Childs Nerv Syst 2000; 16 (09) 551-554
- 25 Howard RS, Thorpe J, Barker R. et al. Respiratory insufficiency due to high anterior cervical cord infarction. J Neurol Neurosurg Psychiatry 1998; 64 (03) 358-361
- 26 Amlie-Lefond C, deVeber G, Chan AK. et al; International Pediatric Stroke Study. Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study. Lancet Neurol 2009; 8 (06) 530-536
- 27 Focke JK, Seitz RJ. Reversal of acute spinal cord ischemia by intravenous thrombolysis. Neurol Clin Pract 2021; 11 (06) e975-e976