Download PDF
CC BY-NC-ND 4.0 · Journal of Clinical Interventional Radiology ISVIR
DOI: 10.1055/s-0044-1778701
Case Report

MVP-Assisted Temporary Vascular Occlusion during 90Y Radioembolization: A Case Report

John J. Park 
1   Department of Radiology, Division of Interventional Radiology, City of Hope Comprehensive Cancer Center, Duarte, California, United States
,
Franz Edward Boas
1   Department of Radiology, Division of Interventional Radiology, City of Hope Comprehensive Cancer Center, Duarte, California, United States
,
Federico Pedersoli
1   Department of Radiology, Division of Interventional Radiology, City of Hope Comprehensive Cancer Center, Duarte, California, United States
› Author Affiliations Funding J.J.P. is a proctor for Sirtex Medical, Inc., and medical advisory board member for Boston Scientific.
F.E.B. is a co-founder of Claripacs, LLC. He received research grants from Guerbet, Society of Interventional Oncology, Department of Defense, Thompson Family Foundation, Brockman Medical Research Foundation, and City of Hope. He received research support (investigator-initiated) from GE Healthcare. He received research supplies (investigator-initiated) from Boston Scientific. He is an investor in Labdoor, Qventus, CloudMedx, Notable Labs, Xgenomes, and Solugen. He is the inventor and assignee on U.S. patent 8233586.
› Further Information
   Permissions and Reprints

Abstract

Yttrium-90 radioembolization is an effective treatment for liver cancers. However, deposition of radioactive microspheres in nondiseased liver can result in parenchymal injury. Segmental and subsegmental radioembolization may reduce off-target liver damage but may not always be possible due to anatomy. In this case report, we highlight the use of a microvascular plug (MVP) to protect distal nondiseased liver and redirect flow into the proximal tumor-containing liver volume during radioembolization of a gallbladder cancer recurrence. Throughout the report, we describe the technique, advantages, and limitations of using MVP-assisted temporary vascular occlusion during organ protection.

Keywords

radioembolization - temporary vascular occlusion - microvascular plug


Publication History

Article published online:
29 January 2024

© 2024. Indian Society of Vascular and Interventional Radiology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Reincke M, Schultheiss M, Doppler M. et al. Hepatic decompensation after transarterial radioembolization: a retrospective analysis of risk factors and outcome in patients with hepatocellular carcinoma. Hepatol Commun 2022; 6 (11) 3223-3233
    CrossrefPubMedGoogle Scholar
  • 2 Pedersoli F, Boas FE, Park JJ. Temporary vascular occlusion with retrievable microvascular plugs to protect normal liver during yttrium-90 radioembolization. J Vasc Interv Radiol 2023; 34 (06) 978-982
    CrossrefPubMedGoogle Scholar
  • 3 Core JM, Frey GT, Sharma A. et al. Increasing yttrium-90 dose conformality using proximal radioembolization enabled by distal angiosomal truncation for the treatment of hepatic malignancy. J Vasc Interv Radiol 2020; 31 (06) 934-942
    CrossrefPubMedGoogle Scholar
  • 4 Meyer C, Pieper CC, Ezziddin S, Wilhelm KE, Schild HH, Ahmadzadehfar H. Feasibility of temporary protective embolization of normal liver tissue using degradable starch microspheres during radioembolization of liver tumours. Eur J Nucl Med Mol Imaging 2014; 41 (02) 231-237
    CrossrefPubMedGoogle Scholar