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CC BY 4.0 · Glob Med Genet 2024; 11(01): 069-075
DOI: 10.1055/s-0044-1779040
Original Article

The Relationship between VDR Gene Polymorphisms Bsm1 and Apa1 with Breast Cancer Risk

Hengameh Mozaffarizadeh
1   Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran
,
Fariborz Mokarian
2   Department of Clinical Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
,
Mansoor Salehi
1   Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran
,
Seyyed Mohammad Reza Hakimian
3   Department of Clinical Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
,
Elham Moazam
3   Department of Clinical Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
,
Amirmohammad Amoozadehsamakoosh
4   Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
,
Majid Hosseinzadeh
1   Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran
,
Mahdieh Behnam
1   Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran
,
Mohaddeseh Behjati
5   Department of Medicine, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
,
Alma Naseri
6   Department of Medical Biotechnology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
,
Marzieh Lotfi
7   Department of Medical Genetics, Abortion Research Center, Reproductive Sciences Institute, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
,
Fatemeh Tohidi
8   Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
9   Department of Medical Biotechnology, Cancer Research Center, School of Medicine, Babol University of Medical Sciences, Babol, Iran
› Author Affiliations Funding None.
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Abstract

Background In addition to its multifaceted physiological functions, vitamin D is recognized for its protective role against cancer. To manifest its effects, vitamin D engages with the vitamin D receptor (VDR) gene responsible for its encoding. Investigations have unveiled that polymorphisms within the VDR gene exert influence over the expression and/or functionality of the VDR protein. Notably, certain VDR gene polymorphisms have emerged as particularly pertinent in the context of tumorigenesis, including Fok1 (rs2228570), Bsm1 (rs1544410), Taq1 (rs771236), and Apa1 (rs7975232). This study aims to scrutinize the correlation between the Bsm1 and Apa1 polymorphisms and the susceptibility to breast cancer development.

Materials and Methods In this study, 50 patients suffering from breast cancer with less than 6 months breast cancer diagnosis and 50 healthy control individuals have been chosen. Restriction fragment length polymorphism polymerase chain reaction was used to determine the genotype of polymorphisms.

Results The results of the statistical analysis showed that among the studied polymorphisms, there was no correlation with the development of breast cancer.

Conclusion Studies on various cancers have produced inconsistent results regarding vitamin D's role in the development and progression of cancer. Therefore, further research is necessary to determine vitamin D's role in cancer development and progression.

Keywords

breast cancer - VDR gene - polymorphism

Authors' Contribution

All authors have read and approved the final version of the manuscript and have agreed to be accountable for all aspects of the work, ensuring its accuracy and integrity.


Data Availability Statement

All data generated or analyzed during this study are included in this published article.




Publication History

Article published online:
04 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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