Subscribe to RSS
DOI: 10.1055/s-0044-1779397
Impact of reanalysis of nitrogen multiple-breath washout on its relationship with chest magnetic resonance imaging findings in clinically stable and pulmonary exacerbated children with cystic fibrosis
Hintergrund Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects lung disease in children with cystic fibrosis (CF). Correction of a cross-talk error in the software of the MBW device Exhalyzer D in a new software version has generated significant interest regarding its impact on previous MBW findings. Since LCI and chest magnetic resonance imaging (MRI) correlated before in CF children, this study aims to reassess previous MBW data after correction.
Methoden Reanalysis of the main findings from a previously published study comparing MBW and MRI in a pediatric CF cohort by reassessment of nitrogen (N2) MBW of 61 stable children with CF, 75 age-matched healthy controls (HC), and 15 CF children with pulmonary exacerbation (PEx) in the corrected software version.
Ergebnisse The corrected LCI (N2LCIcor) decreased in the entire cohort (−17.0 (11.2) %), HC (−8.5 (8.2) %), stable CF children (−22.2 (11.1) %), and within the PEx group at baseline, at PEx and after antibiotic therapy (−21.5 (7.3) %; −22.5 (6.1) %; −21.4 (6.6) %; all P < 0.01). N2LCIcor and N2LCIpre correlated with chest MRI scores in stable CF (r = 0.70 to 0.84; all P < 0.01) without a significant difference between N2LCIcor and N2LCIpre. Change in LCI from baseline to PEx and from PEx to after therapy decreased from N2LCIpre to N2LCIcor, but these changes remained significant (all P = 0.001).
Schlussfolgerung Our results show that the N2LCIcor is significantly lower than the N2LCIpre, but the key results published in the original study, indicating N2MBW and MRI as complementary methods for clinical monitoring in children with CF, remain unaffected.
Publication History
Article published online:
22 February 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany