An Overview of the Synthesis of Hexafluoroisopropanol and Its Key Intermediates

Abstract

Hexafluoroisopropanol (HFIP, 1,1,1,3,3,3-hexafluoro-2-propanol) is a fluorine-containing alcohol, which can be used in the preparation of fluorine-containing fine chemical, pharmaceutical, and pesticide ingredient. It is a widely used solvent in organic reactions that is miscible with water and many organic reagents. Hexafluoroacetone (HFA) is a key intermediate in the synthesis of HFIP. In this work, six methods for synthesizing HFA are discussed based on the different raw materials used. In addition, three methods of synthesizing HFIP, and the applications of HFIP are also reviewed.

Keywords

hexafluoroisopropanol - hexafluoroacetone - synthetic route

Publication History

Received: 31 July 2023

Accepted: 15 January 2024

Article published online:
01 March 2024

• Reference

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