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CC BY 4.0 · Pharmaceutical Fronts 2024; 06(01): e1-e8
DOI: 10.1055/s-0044-1779594
Review Article

An Overview of the Synthesis of Hexafluoroisopropanol and Its Key Intermediates

Guihua Luo
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Weike Su
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
2   Zhejiang Governor Triangle Biomedical Industrial Technology Research Park, Huzhou, People's Republic of China
› Author Affiliations Funding We gratefully acknowledge the Zhejiang Province Science and Technology Plan Project (Grant Nos. 2022C01179 and 2019-ZJ-JS-03) for financial support.
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Abstract

Hexafluoroisopropanol (HFIP, 1,1,1,3,3,3-hexafluoro-2-propanol) is a fluorine-containing alcohol, which can be used in the preparation of fluorine-containing fine chemical, pharmaceutical, and pesticide ingredient. It is a widely used solvent in organic reactions that is miscible with water and many organic reagents. Hexafluoroacetone (HFA) is a key intermediate in the synthesis of HFIP. In this work, six methods for synthesizing HFA are discussed based on the different raw materials used. In addition, three methods of synthesizing HFIP, and the applications of HFIP are also reviewed.

Keywords

hexafluoroisopropanol - hexafluoroacetone - synthetic route


Publication History

Received: 31 July 2023

Accepted: 15 January 2024

Article published online:
01 March 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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