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CC BY-NC-ND 4.0 · Journal of Fetal Medicine 2023; 10(04): 187-194
DOI: 10.1055/s-0044-1779752
SFM Practice Guidelines

SFM Fetal Therapy Practice Guidelines: Intrauterine Blood Transfusion

Seneesh Kumar Vikraman 
1   Centre for Prenatal Diagnosis and Fetal Therapy, ARMC AEGIS Hospital Perinthalmana and Aster MIMS hospital, Kottakal, Malappuram, Kerala, India
,
Manikandan Krishnan
2   Department of Fetal Medicine, The Fetal Clinic, Pondicherry, Kerala, India
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Abstract

Despite routine antenatal anti-D prophylaxis with immunoglobulin, Rh alloimmunization and hemolytic disease of the fetus and newborn continue to occur due to a myriad of reasons. Intrauterine intravascular transfusion (IUT) or fetal blood transfusion is a therapeutic prenatal procedure in which specifically prepared and treated unit of donor red blood cells is injected intravascularly into the umbilical vein under ultrasound guidance. Originally introduced in the year 1963, it continues to be the standard treatment for severe fetal anemia. The objective of this guideline is to provide an evidence-based update of IUT for the perinatal healthcare providers.

Keywords

ICT - intrauterine transfusion - MCA PSV - Rh D alloimmunization

Informed Consent

Informed consent was obtained from all women.




Publication History

Article published online:
21 March 2024

© 2024. Society of Fetal Medicine. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Liley AW. Intrauterine transfusion of foetus in haemolytic disease. BMJ 1963; 2 (5365): 1107-1109
    CrossrefPubMedGoogle Scholar
  • 2 Rodeck CH, Nicolaides KH, Warsof SL, Fysh WJ, Gamsu HR, Kemp JR. The management of severe rhesus isoimmunization by fetoscopic intravascular transfusions. Am J Obstet Gynecol 1984; 150 (06) 769-774
    CrossrefPubMedGoogle Scholar
  • 3 Nicolini U, Nicolaidis P, Fisk NM, Tannirandorn Y, Rodeck CH. Fetal blood sampling from the intrahepatic vein: analysis of safety and clinical experience with 214 procedures. Obstet Gynecol 1990; 76 (01) 47-53
    PubMedGoogle Scholar
  • 4 Mari G, Deter RL, Carpenter RL. et al; Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses. Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. N Engl J Med 2000; 342 (01) 9-14
    CrossrefPubMedGoogle Scholar
  • 5 Oepkes D, Seaward PG, Vandenbussche FP. et al; DIAMOND Study Group. Doppler ultrasonography versus amniocentesis to predict fetal anemia. N Engl J Med 2006; 355 (02) 156-164
    CrossrefPubMedGoogle Scholar
  • 6 Moise KJ. Fetal anemia due to non-Rhesus-D red-cell alloimmunization. Semin Fetal Neonatal Med 2008; 13 (04) 207-214
    CrossrefPubMedGoogle Scholar
  • 7 Lindenburg IT, van Kamp IL, Oepkes D. Intrauterine blood transfusion: current indications and associated risks. Fetal Diagn Ther 2014; 36 (04) 263-271
    CrossrefPubMedGoogle Scholar
  • 8 Pasman SA, Claes L, Lewi L. et al. Intrauterine transfusion for fetal anemia due to red blood cell alloimmunization: 14 years experience in Leuven. Facts Views Vis ObGyn 2015; 7 (02) 129-136
    PubMedGoogle Scholar
  • 9 Zwiers C, Lindenburg ITM, Klumper FJ, de Haas M, Oepkes D, Van Kamp IL. Complications of intrauterine intravascular blood transfusion: lessons learned after 1678 procedures. Ultrasound Obstet Gynecol 2017; 50 (02) 180-186
    CrossrefPubMedGoogle Scholar
  • 10 van Kamp IL, Klumper FJ, Meerman RH, Oepkes D, Scherjon SA, Kanhai HH. Treatment of fetal anemia due to red-cell alloimmunization with intrauterine transfusions in the Netherlands, 1988-1999. Acta Obstet Gynecol Scand 2004; 83 (08) 731-737
    CrossrefPubMedGoogle Scholar