Digestive Disease Interventions 2024; 08(02): 130-136
DOI: 10.1055/s-0044-1782149
Review Article

Interventional Radiology Management of Pediatric Liver Tumors

Tammy Kim
1   Department of Radiology, Boston Children's Hospital, Boston, Massachusetts
,
1   Department of Radiology, Boston Children's Hospital, Boston, Massachusetts
› Institutsangaben

Abstract

Pediatric liver tumors are not only rare, they are also different from the adult liver tumors. Hepatoblastomas and hepatocellular carcinomas (HCCs) are the most common primary malignant tumors seen in children. Fibrolamellar HCC, sarcomas, cholangiocarcinoma, germ cell tumor, and rhabdoid tumor and metastatic tumors comprise the remainder of liver malignancies. Hepatic infantile hemangiomas, mesenchymal hamartoma, regenerative nodules, adenomas, and focal nodular hyperplasia are the common benign liver tumors of childhood. The Pediatric Hepatic International Tumour Trial (PHITT) is an international trial with the goal of evaluating new and existing treatments for pediatric liver tumors. Chemotherapy, surgery, and liver transplantation are well-established in the management of pediatric liver tumors. In the background of increasing incidence of pediatric tumors, and availability of newer, less invasive modalities to treat tumors, it is vital to understand the role of interventional radiology in the management of pediatric liver tumors.



Publikationsverlauf

Eingereicht: 30. Dezember 2023

Angenommen: 02. Februar 2024

Artikel online veröffentlicht:
14. März 2024

© 2024. Thieme. All rights reserved.

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333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Aronson DC, Meyers RL. Malignant tumors of the liver in children. Semin Pediatr Surg 2016; 25 (05) 265-275
  • 2 Sindhi R, Rohan V, Bukowinski A. et al. Liver transplantation for pediatric liver cancer. Cancers (Basel) 2020; 12 (03) 720
  • 3 Meyers R, Hiyama E, Czauderna P, Tiao GM. Liver tumors in pediatric patients. Surg Oncol Clin N Am 2021; 30 (02) 253-274
  • 4 Matthew Hawkins C, Towbin AJ, Roebuck DJ. et al. Role of interventional radiology in managing pediatric liver tumors : Part 2: percutaneous interventions. Pediatr Radiol 2018; 48 (04) 565-580
  • 5 Chavhan GB, Siddiqui I, Ingley KM, Gupta AA. Rare malignant liver tumors in children. Pediatr Radiol 2019; 49 (11) 1404-1421
  • 6 Katzenstein HM, Krailo MD, Malogolowkin MH. et al. Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study. J Clin Oncol 2002; 20 (12) 2789-2797
  • 7 Schmid I, von Schweinitz D. Pediatric hepatocellular carcinoma: challenges and solutions. J Hepatocell Carcinoma 2017; 4: 15-21
  • 8 Digiacomo G, Serra RP, Turrini E. et al. State of the art and perspectives in pediatric hepatocellular carcinoma. Biochem Pharmacol 2023; 207: 115373
  • 9 Golabi P, Fazel S, Otgonsuren M, Sayiner M, Locklear CT, Younossi ZM. Mortality assessment of patients with hepatocellular carcinoma according to underlying disease and treatment modalities. Medicine (Baltimore) 2017; 96 (09) e5904
  • 10 Towbin AJ, Meyers RL, Woodley H. et al. 2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT). Pediatr Radiol 2018; 48 (04) 536-554
  • 11 Kelgeri C, Renz D, McGuirk S, Schmid I, Sharif K, Baumann U. Liver tumours in children: the hepatologist's view. J Pediatr Gastroenterol Nutr 2021; 72 (04) 487-493
  • 12 Azzam RK, Alonso EM, Emerick KM, Whitington PF. Safety of percutaneous liver biopsy in infants less than three months old. J Pediatr Gastroenterol Nutr 2005; 41 (05) 639-643
  • 13 López-Terrada D, Alaggio R, de Dávila MT. et al; Children's Oncology Group Liver Tumor Committee. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol 2014; 27 (03) 472-491
  • 14 Padia SA, Baker ME, Schaeffer CJ. et al. Safety and efficacy of sonographic-guided random real-time core needle biopsy of the liver. J Clin Ultrasound 2009; 37 (03) 138-143
  • 15 Short SS, Papillon S, Hunter CJ. et al. Percutaneous liver biopsy: pathologic diagnosis and complications in children. J Pediatr Gastroenterol Nutr 2013; 57 (05) 644-648
  • 16 Nobili V, Comparcola D, Sartorelli MR. et al. Blind and ultrasound-guided percutaneous liver biopsy in children. Pediatr Radiol 2003; 33 (11) 772-775
  • 17 Matos H, Noruegas MJ, Gonçalves I, Sanches C. Effectiveness and safety of ultrasound-guided percutaneous liver biopsy in children. Pediatr Radiol 2012; 42 (11) 1322-1325
  • 18 Patel IJ, Rahim S, Davidson JC. et al. Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions-Part II: Recommendations: Endorsed by the Canadian Association for Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe. J Vasc Interv Radiol 2019; 30 (08) 1168-1184.e1
  • 19 Khoriaty E, McClain CD, Permaul P, Smith ER, Rachid R. Intraoperative anaphylaxis induced by the gelatin component of thrombin-soaked Gelfoam in a pediatric patient. Ann Allergy Asthma Immunol 2012; 108 (03) 209-210
  • 20 Gómez FM, Patel PA, Stuart S, Roebuck DJ. Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children. Pediatr Radiol 2014; 44 (10) 1281-1289
  • 21 van Laarhoven S, van Baren R, Tamminga RY, de Jong KP. Radiofrequency ablation in the treatment of liver tumors in children. J Pediatr Surg 2012; 47 (03) e7-e12
  • 22 Yevich S, Calandri M, Gravel G. et al. Reiterative radiofrequency ablation in the management of pediatric patients with hepatoblastoma metastases to the lung, liver, or bone. Cardiovasc Intervent Radiol 2019; 42 (01) 41-47
  • 23 Hong K, Georgiades C. Radiofrequency ablation: mechanism of action and devices. J Vasc Interv Radiol 2010; 21 (8, Suppl): S179-S186
  • 24 Liu Z, Ahmed M, Weinstein Y, Yi M, Mahajan RL, Goldberg SN. Characterization of the RF ablation-induced 'oven effect': the importance of background tissue thermal conductivity on tissue heating. Int J Hyperthermia 2006; 22 (04) 327-342
  • 25 Gervais DA, Goldberg SN, Brown DB, Soulen MC, Millward SF, Rajan DK. Society of Interventional Radiology position statement on percutaneous radiofrequency ablation for the treatment of liver tumors. J Vasc Interv Radiol 2009; 20 (7, Suppl): S342-S347
  • 26 Livraghi T, Goldberg SN, Lazzaroni S. et al. Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology 2000; 214 (03) 761-768
  • 27 Hinshaw JL, Lubner MG, Ziemlewicz TJ, Lee Jr FT, Brace CL. Percutaneous tumor ablation tools: microwave, radiofrequency, or cryoablation – what should you use and why?. Radiographics 2014; 34 (05) 1344-1362
  • 28 Fan W, Li X, Zhang L, Jiang H, Zhang J. Comparison of microwave ablation and multipolar radiofrequency ablation in vivo using two internally cooled probes. AJR Am J Roentgenol 2012; 198 (01) W46-W50
  • 29 Jiang Y, Zhou S, Shen G, Jiang H, Zhang J. Microwave ablation combined with transcatheter arterial chemoembolization is effective for treating unresectable hepatoblastoma in infants and children. Medicine (Baltimore) 2018; 97 (42) e12607
  • 30 Maybody M. An overview of image-guided percutaneous ablation of renal tumors. Semin Intervent Radiol 2010; 27 (03) 261-267
  • 31 Georgiades CS, Hong K, Bizzell C, Geschwind JF, Rodriguez R. Safety and efficacy of CT-guided percutaneous cryoablation for renal cell carcinoma. J Vasc Interv Radiol 2008; 19 (09) 1302-1310
  • 32 Jansen MC, van Hillegersberg R, Schoots IG. et al. Cryoablation induces greater inflammatory and coagulative responses than radiofrequency ablation or laser induced thermotherapy in a rat liver model. Surgery 2010; 147 (05) 686-695
  • 33 Lee EW, Chen C, Prieto VE, Dry SM, Loh CT, Kee ST. Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology 2010; 255 (02) 426-433
  • 34 Cheung TT, Fan ST, Chan SC. et al. High-intensity focused ultrasound ablation: an effective bridging therapy for hepatocellular carcinoma patients. World J Gastroenterol 2013; 19 (20) 3083-3089
  • 35 Cheung TT, Fan ST, Chu FS. et al. Survival analysis of high-intensity focused ultrasound ablation in patients with small hepatocellular carcinoma. HPB (Oxford) 2013; 15 (08) 567-573
  • 36 Wang S, Yang C, Zhang J. et al. First experience of high-intensity focused ultrasound combined with transcatheter arterial embolization as local control for hepatoblastoma. Hepatology 2014; 59 (01) 170-177
  • 37 Snoeren N, Huiskens J, Rijken AM. et al. Viable tumor tissue adherent to needle applicators after local ablation: a risk factor for local tumor progression. Ann Surg Oncol 2011; 18 (13) 3702-3710
  • 38 Hickey R, Vouche M, Sze DY. et al. Cancer concepts and principles: primer for the interventional oncologist-part II. J Vasc Interv Radiol 2013; 24 (08) 1167-1188
  • 39 Shaikh R, Munoz FG. Endovascular approaches in pediatric interventional oncology. CVIR Endovasc 2021; 4 (01) 2
  • 40 Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, Takashima S. Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 1983; 148 (02) 397-401
  • 41 Nakamura H, Hashimoto T, Inoue Y, Inoue K, Akaji H, Sawada S. Transcatheter oily chemoembolization with high doses of Adriamycin in the treatment of large hepatocellular carcinoma (10 cm or more in diameter). Radiat Med 1990; 8 (05) 188-190
  • 42 Bruix J, Sherman M. American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update. Hepatology 2011; 53 (03) 1020-1022
  • 43 Carr BI, Kondragunta V, Buch SC, Branch RA. Therapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma: a two-cohort study. Cancer 2010; 116 (05) 1305-1314
  • 44 Lesurtel M, Müllhaupt B, Pestalozzi BC, Pfammatter T, Clavien PA. Transarterial chemoembolization as a bridge to liver transplantation for hepatocellular carcinoma: an evidence-based analysis. Am J Transplant 2006; 6 (11) 2644-2650
  • 45 Arcement CM, Towbin RB, Meza MP. et al. Intrahepatic chemoembolization in unresectable pediatric liver malignancies. Pediatr Radiol 2000; 30 (11) 779-785
  • 46 De Luna W, Sze DY, Ahmed A. et al. Transarterial chemoinfusion for hepatocellular carcinoma as downstaging therapy and a bridge toward liver transplantation. Am J Transplant 2009; 9 (05) 1158-1168
  • 47 Kennedy AS, Nutting C, Coldwell D, Gaiser J, Drachenberg C. Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol Biol Phys 2004; 60 (05) 1552-1563
  • 48 Chen JH, Chai JW, Huang CL, Hung HC, Shen WC, Lee SK. Proximal arterioportal shunting associated with hepatocellular carcinoma: features revealed by dynamic helical CT. AJR Am J Roentgenol 1999; 172 (02) 403-407
  • 49 Memeo R, Conticchio M, Deshayes E. et al. Optimization of the future remnant liver: review of the current strategies in Europe. Hepatobiliary Surg Nutr 2021; 10 (03) 350-363
  • 50 Fischman AM, Ward TJ, Horn JC. et al. Portal vein embolization before right hepatectomy or extended right hepatectomy using sodium tetradecyl sulfate foam: technique and initial results. J Vasc Interv Radiol 2014; 25 (07) 1045-1053
  • 51 Shoup M, Gonen M, D'Angelica M. et al. Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection. J Gastrointest Surg 2003; 7 (03) 325-330
  • 52 Aoki T, Kubota K. Preoperative portal vein embolization for hepatocellular carcinoma: consensus and controversy. World J Hepatol 2016; 8 (09) 439-445