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CC BY 4.0 · Avicenna J Med 2024; 14(02): 075-109
DOI: 10.1055/s-0044-1782202
Review Article

Renal Cell Carcinoma Metastasizing to Oral Soft Tissues: Systematic Review

Harnisha Vipulkumar Prajapati
1   Bhavya Dental Clinic and Implant Centre, Palanpur, Gujarat, India
,
Ruchira Shreevats
2   Primadent Dental Centre, Bangalore, Karnataka, India
,
Sonia Gupta 
3   Department of Oral Pathology and Microbiology & Forensic Odontology, Yamuna Institute of Dental Sciences and Research, Yamunanagar, Haryana, India
,
Harman Sandhu
4   Building Smiles Dental Clinic, Mohali, Punjab, India
,
Jaskirat Kaur 
5   Dentistry in Motion, North York, Ontario, Canada
,
Jasmine Kaur
6   St. Joseph Healthcare Centre, Toronto, Canada
› Author Affiliations Funding None.
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Abstract

Background Renal cancer metastasis to oral region is very rare. Studies have been published analyzing the cases of metastatic tumors to the oral cavity by many researchers. Very few research studies have been conducted till date to analyze the renal cancer metastasis as the sole primary source to the oral soft tissues. The goal of this study was to examine the published cases of oral soft tissue metastasis from renal cell carcinoma as the only primary source from 1911 to 2022.

Materials and Methods An electronic search of the published literature was performed without publication year limitation in PubMed/Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (“Renal cancer,” or “Renal carcinoma” or “Renal cell cancer” or “Renal cell carcinoma”), and (“Metastasis” or “Metastases”), and (“Oral soft tissues” or “Tongue” or “Palate” or “Tonsil” or “Buccal mucosa” or “Salivary glands”). We also searched related journals manually and the reference lists.

Results Our research revealed a total of 226 relevant articles with 250 patients. Parotid glands and tongue were the most common sites of metastasis. 23% patients died with a survival time of 10 days to 4 years.

Conclusions Oral soft tissue metastasis from renal cell carcinoma has a bad prognosis. More cases need to be published in order to raise awareness of these lesions.

Keywords

renal cell cancer - metastasis - oral - soft tissues

Abbreviations

BM: Buccal mucosa, CCC: Clear cell carcinoma, HP: Hard palate, LC: Lung cancer, NA: Not available, OST: Oral soft tissues, OSTM: Oral soft tissue metastasis, RCC: Renal cell carcinoma, SMG: Submandibular gland, SP: Soft palate.


Ethical Approval

Not required.


Ethical Approval and Consent to Participate

Not applicable.


Consent for Publication

Not applicable.


Availability of Data and Material

Electronic research.


Competing Interests

None.


Authors' Contributions

• S.G., H.V.P.: Conceptualization, data curation, investigation, methodology, project administration, resources, validation, writing—original draft, writing—review and editing, supervision.


• R.V., H.S., J.K., J.K.: Investigation, methodology, project administration, validation.




Publication History

Article published online:
06 May 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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