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CC BY 4.0 · Pharmaceutical Fronts 2024; 06(02): e119-e135
DOI: 10.1055/s-0044-1786042
Review Article

A Bibliometric Analysis of the Gene Delivery Systems for Lung Cancer from 2010 to 2022

Kexin Wu
1   Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China
,
Fang Ren
1   Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China
,
Lu Zhou
1   Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China
,
Yangchen Xing
1   Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China
,
Qianyu Zhang
1   Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China
,
Huali Chen
1   Department of Pharmaceutics, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China
› Author Affiliations Funding This work was supported by the Natural Science Foundation of Chongqing (Grant No. 2023 NSCQ-MSX0440) and the Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202000 407).
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Abstract

The gene delivery systems (GDS) for lung cancer (LC) has made significant progress over the past 12 years, yet, there is a great challenge in its clinical application due to low delivery efficiency. This study aims to explore research fields related to gene therapy for LC and predict future directions from a bibliometric perspective. The Web of Science Core Collection collects articles and reviews on GDS for LC published from 2010 to 2022. Comprehensive bibliometric and visual analyses were performed using CiteSpace, VOSviewer, R-Bibliometrix, and Microsoft Excel. The analysis showed that the number of publications on GDS for LC has been increasing over the past 12 years, highlighting the growing interest and research efforts in this area. A rigorous examination of keywords and research hotspots revealed that the themes such as “complex,” “transfection,” “RNA interference,” “extracellular vesicle,” “co-deliver,” “resistance,” etc. dominate the field of GDS for LC. These findings indicated that the research in GDS for LC is evolving, with a noticeable shift toward addressing challenges related to delivery efficiency, transfection methods, and overcoming resistance mechanisms in gene therapy. The comprehensive study provides an overview of the literature on GDS for LC and identifies areas that require further exploration and development. By highlighting emerging research hotspots, our bibliometric analysis offers valuable insights to scholars and researchers, aiding in the identification of gaps, and guiding future efforts toward the development of GDS with more efficiency for LC therapy.

Keywords

lung cancer - gene delivery system - Bibliometric analysis

Data Availability Statement

The original contributions presented in the study were included in the article, and further inquiries can be directed to the corresponding author.




Publication History

Received: 08 August 2023

Accepted: 22 March 2024

Article published online:
31 May 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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