CC BY-NC-ND 4.0 · Aorta (Stamford)
DOI: 10.1055/s-0044-1786352
State-of-the-Art Review

The Fate of Conventional Elephant Trunk in the Frozen Elephant Trunk Era

Alexander Geragotellis
1   Faculty of Health Sciences, University of Cape Town, Observatory, South Africa
,
2   Hull York Medical School, University of York, York
,
Mohammed Al-Tawil
3   Faculty of Medicine, Al-Quds University, Jerusalem, Palestine
,
Idhrees Mohammed
4   Institute of Cardiac and Aortic Disorders (ICAD), SRM Institutes for Medical Science (SIMS Hospital), Chennai, Tamil Nadu, India
,
4   Institute of Cardiac and Aortic Disorders (ICAD), SRM Institutes for Medical Science (SIMS Hospital), Chennai, Tamil Nadu, India
5   Department of Vascular & Endovascular Surgery, Velindre University NHS Trust, Health Education and Improvement Wales (HEIW), Cardiff, United Kingdom
6   Heart Valve Disease Research Centre, Rajaie Cardiovascular Medical and Research Centre, Iran University of Medical Sciences, Tehran, Iran
,
Saeid Hosseini
6   Heart Valve Disease Research Centre, Rajaie Cardiovascular Medical and Research Centre, Iran University of Medical Sciences, Tehran, Iran
› Author Affiliations

Abstract

Conventional elephant trunk (cET) and frozen elephant trunk (FET) are two distinct approaches to the surgical treatment of thoracic aortic aneurysms and dissections. With the advent and growing uptake of endovascular technologies, FET is becoming increasingly popular for its potential to be performed as a single-stage operation with better aortic remodeling and less risk of graft kinking than the traditional two-stage cET procedure. However, FET has been associated with a higher risk of spinal cord ischemia and its use in patients with connective tissue disorder remains controversial. The current review aimed to reflect on recent evidence surrounding the application of cET and FET to different types of aortic pathology in both acute and elective settings. Another scope of this review was to compare the characteristics of the currently available FET commercial devices on the global market. Our findings highlight that when the pathology is confined to the proximal descending aorta, such as in Dsine, intervention is often single-staged and false lumen (FL) thrombosis is achieved with good effect. FET remains limited by spinal cord injury and applicability in patients with connective tissue disorder, although some groups have started to circumvent associated complications, likely due to growing surgical expertise. Many other aortic diseases do require second-stage intervention, and even in these cases, there appears to be lower in-hospital mortality when using FET over cET. This is possibly due to the higher rate of endovascular completion facilitated by the completed landing zones created during FET. FET is trending toward becoming the universal treatment modality for extending repair to the descending aorta

Authors' Contribution

A.G., M.J. and M.T. involved in literature review design, literature search, and manuscript writing. M.B., I.M., and S.H. involved in manuscript revision.




Publication History

Received: 03 May 2022

Accepted: 08 March 2023

Article published online:
16 May 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Borst HG, Walterbusch G, Schaps D. Extensive aortic replacement using “elephant trunk” prosthesis. Thorac Cardiovasc Surg 1983; 31 (01) 37-40
  • 2 Borst HG. The birth of the elephant trunk technique. J Thorac Cardiovasc Surg 2013; 145 (01) 44
  • 3 Shrestha M, Martens A, Krüger H. et al. Total aortic arch replacement with the elephant trunk technique: single-centre 30-year results. Eur J Cardiothorac Surg 2014; 45 (02) 289-295 , discussion 295–296
  • 4 Shrestha M, Beckmann E, Krueger H. et al. The elephant trunk is freezing: the Hannover experience. J Thorac Cardiovasc Surg 2015; 149 (05) 1286-1293
  • 5 Di Eusanio M, Pantaleo A, Murana G. et al. Frozen elephant trunk surgery—the Bologna's experience. Ann Cardiothorac Surg 2013; 2 (05) 597-605
  • 6 Kato M, Ohnishi K, Kaneko M. et al. Development of an expandable intra-aortic prosthesis for experimental aortic dissection. ASAIO J 1993; 39 (03) M758-M761
  • 7 Kato M, Ohnishi K, Kaneko M. et al. New graft-implanting method for thoracic aortic aneurysm or dissection with a stented graft. Circulation 1996; 94 (09) II188-II193
  • 8 Castrovinci S, Murana G, de Maat GE. et al. The classic elephant trunk technique for staged thoracic and thoracoabdominal aortic repair: long-term results. J Thorac Cardiovasc Surg 2015; 149 (02) 416-422
  • 9 Karck M, Chavan A, Hagl C, Friedrich H, Galanski M, Haverich A. The frozen elephant trunk technique: a new treatment for thoracic aortic aneurysms. J Thorac Cardiovasc Surg 2003; 125 (06) 1550-1553
  • 10 Hanif H, Dubois L, Ouzounian M. et al; Canadian Thoracic Aortic Collaborative (CTAC) Investigators. Aortic arch reconstructive surgery with conventional techniques vs frozen elephant trunk: a systematic review and meta-analysis. Can J Cardiol 2018; 34 (03) 262-273
  • 11 Bozso SJ, White A, Nagendran J, Moon MC, Chu MWA. Hybrid aortic arch and frozen elephant trunk reconstruction: bridging the gap between conventional and total endovascular arch repair. Expert Rev Cardiovasc Ther 2018; 16 (03) 209-217
  • 12 Kreibich M, Berger T, Rylski B. et al. Aortic reinterventions after the frozen elephant trunk procedure. J Thorac Cardiovasc Surg 2020; 159 (02) 392-399.e1
  • 13 Tsagakis K, Pacini D, Di Bartolomeo R. et al. Multicenter early experience with extended aortic repair in acute aortic dissection: is simultaneous descending stent grafting justified?. J Thorac Cardiovasc Surg 2010; 140 (06) S116-S120 , discussion S142–S146
  • 14 Jakob H, Tsagakis K, Pacini D. et al. The International E-vita Open Registry: data sets of 274 patients. J Cardiovasc Surg (Torino) 2011; 52 (05) 717-723
  • 15 Jakob H, Tsagakis K. DeBakey type I dissection: when hybrid stent-grafting is indicated?. J Cardiovasc Surg (Torino) 2010; 51 (05) 633-640
  • 16 Jakob H, Dohle D, Benedik J. et al. Long-term experience with the E-vita Open hybrid graft in complex thoracic aortic disease†. Eur J Cardiothorac Surg 2017; 51 (02) 329-338
  • 17 Shrestha M, Kaufeld T, Beckmann E. et al. Total aortic arch replacement with a novel 4-branched frozen elephant trunk prosthesis: Single-center results of the first 100 patients. J Thorac Cardiovasc Surg 2016; 152 (01) 148-159.e1
  • 18 Berger T, Weiss G, Voetsch A. et al. Multicentre experience with two frozen elephant trunk prostheses in the treatment of acute aortic dissection†. Eur J Cardiothorac Surg 2019; 56 (03) 572-578
  • 19 Safi HJ, Miller III CC, Estrera AL. et al. Optimization of aortic arch replacement: two-stage approach. Ann Thorac Surg 2007; 83 (02) S815-S818 , discussion S824–S831
  • 20 Shrestha M, Bachet J, Bavaria J. et al. Current status and recommendations for use of the frozen elephant trunk technique: a position paper by the Vascular Domain of EACTS. Eur J Cardiothorac Surg 2015; 47 (05) 759-769
  • 21 Palma JH, Almeida DR, Carvalho AC, Andrade JC, Buffolo E. Surgical treatment of acute type B aortic dissection using an endoprosthesis (elephant trunk). Ann Thorac Surg 1997; 63 (04) 1081-1084
  • 22 Etz CD, Plestis KA, Kari FA. et al. Staged repair of thoracic and thoracoabdominal aortic aneurysms using the elephant trunk technique: a consecutive series of 215 first stage and 120 complete repairs. Eur J Cardiothorac Surg 2008; 34 (03) 605-614 , discussion 614–615
  • 23 Tan SZCP, Lopuszko A, Munir W, Adams B, Bashir M. Aortic proximalization-Zone 0 versus Zone 2: a concept or true challenge?. J Card Surg 2021; 36 (09) 3319-3325
  • 24 Di Bartolomeo R, Murana G, Di Marco L. et al. Frozen versus conventional elephant trunk technique: application in clinical practice. Eur J Cardiothorac Surg 2017; 51 (Suppl. 01) i20-i28
  • 25 Leontyev S, Tsagakis K, Pacini D. et al. Impact of clinical factors and surgical techniques on early outcome of patients treated with frozen elephant trunk technique by using EVITA open stent-graft: results of a multicentre study. Eur J Cardiothorac Surg 2016; 49 (02) 660-666
  • 26 Leone A, Di Marco L, Coppola G. et al. Open distal anastomosis in the frozen elephant trunk technique: initial experiences and preliminary results of arch zone 2 versus arch zone 3†. Eur J Cardiothorac Surg 2019; 56 (03) 564-571
  • 27 Chauvette V, Ouzounian M, Chung J. et al; Canadian Thoracic Aortic Collaborative. Review of frozen elephant trunk repair with the Thoraflex Hybrid device. Future Cardiol 2021; 17 (07) 1171-1181
  • 28 Tan SZCP, Bashir M. Prevention versus cure: is BioGlue priming the optimal strategy against E-Vita NEO graft oozing?. J Card Surg 2022; 37 (03) 555-560
  • 29 Di Bartolomeo R, Murana G, Di Marco L. et al. Is the frozen elephant trunk frozen?. Gen Thorac Cardiovasc Surg 2019; 67 (01) 111-117
  • 30 Preventza O, Liao JL, Olive JK. et al. Neurologic complications after the frozen elephant trunk procedure: A meta-analysis of more than 3000 patients. J Thorac Cardiovasc Surg 2020; 160 (01) 20-33.e4
  • 31 Vernice NA, Wingo ME, Walker PB. et al. The great vessel freeze-out: a meta-analysis of conventional versus frozen elephant trunks in aortic arch surgery. J Card Surg 2022; 37 (08) 2397-2407
  • 32 Poon SS, Tian DH, Yan T. et al; International Aortic Arch Surgery Study Group. Frozen elephant trunk does not increase incidence of paraplegia in patients with acute type A aortic dissection. J Thorac Cardiovasc Surg 2020; 159 (04) 1189-1196.e1
  • 33 Mehanna M, Elhamami M, Abolkasem A, Ramadan B, Almaghraby A, Mascaro J. Aortic remodelling and false lumen changes after the frozen elephant trunk technique using the thoraflex hybrid stented graft for aortic dissection. Egypt Heart J 2021; 73 (01) 74
  • 34 Usai MV, Ibrahim A, Oberhuber A. et al. Quantification of volume changes in the descending aorta after frozen elephant trunk procedure using the Thoraflex hybrid prosthesis for type A aortic dissection. J Thorac Dis 2021; 13 (01) 60-66
  • 35 Liu H, Liu S, Zaki A. et al. Quantifying the learning curve of emergent total arch replacement in acute type A aortic dissection. J Thorac Dis 2020; 12 (08) 4070-4081
  • 36 Liu K, Zhu C, Zheng X. et al. A New Aortic Arch Inclusion Technique With Frozen Elephant Trunk for Type A Aortic Dissection. Ann Surg 2020; 271 (05) 978-983
  • 37 Furutachi A, Takamatsu M, Nogami E. et al. Early and mid-term outcomes of total arch replacement with the frozen elephant trunk technique for type A acute aortic dissection. Interact Cardiovasc Thorac Surg 2019; 29 (05) 753-760
  • 38 Roselli EE, Idrees JJ, Bakaeen FG. et al. Evolution of simplified frozen elephant trunk repair for acute DeBakey type i dissection: midterm outcomes. Ann Thorac Surg 2018; 105 (03) 749-755
  • 39 Shrestha M, Martens A, Kaufeld T. et al. Single-centre experience with the frozen elephant trunk technique in 251 patients over 15 years. Eur J Cardiothorac Surg 2017; 52 (05) 858-866
  • 40 Dohle D-S, Tsagakis K, Janosi RA. et al. Aortic remodelling in aortic dissection after frozen elephant trunk†. Eur J Cardiothorac Surg 2016; 49 (01) 111-117
  • 41 Takagi H, Umemoto T. ALICE Group. A meta-analysis of total arch replacement with frozen elephant trunk in acute type a aortic dissection. Vasc Endovascular Surg 2016; 50 (01) 33-46
  • 42 Zhang K, Pan XD, Dong SB. et al. Cardiopulmonary bypass duration is an independent predictor of adverse outcome in surgical repair for acute type A aortic dissection. J Int Med Res 2020; 48 (11) 30 0060520968450
  • 43 Di Marco L, Leone A, Murana G. et al. Acute type A aortic dissection: Rationale and outcomes of extensive repair of the arch and distal aorta. Int J Cardiol 2018; 267: 145-149
  • 44 Di Eusanio M, Castrovinci S, Tian DH. et al. Antegrade stenting of the descending thoracic aorta during DeBakey type 1 acute aortic dissection repair. Eur J Cardiothorac Surg 2014; 45 (06) 967-975
  • 45 Ius F, Fleissner F, Pichlmaier M. et al. Total aortic arch replacement with the frozen elephant trunk technique: 10-year follow-up single-centre experience. Eur J Cardiothorac Surg 2013; 44 (05) 949-957
  • 46 Sun L, Qi R, Zhu J, Liu Y, Zheng J. Total arch replacement combined with stented elephant trunk implantation: a new “standard” therapy for type a dissection involving repair of the aortic arch?. Circulation 2011; 123 (09) 971-978
  • 47 Jakob H, Dohle DS, Piotrowski J. et al. Six-year experience with a hybrid stent graft prosthesis for extensive thoracic aortic disease: an interim balance. Eur J Cardiothorac Surg 2012; 42 (06) 1018-1025
  • 48 Uchida N, Katayama A, Tamura K. et al. Long-term results of the frozen elephant trunk technique for extended aortic arch disease. Eur J Cardiothorac Surg 2010; 37 (06) 1338-1345
  • 49 Di Bartolomeo R, Pantaleo A, Berretta P. et al. Frozen elephant trunk surgery in acute aortic dissection. J Thorac Cardiovasc Surg 2015; 149 (02) S105-S109
  • 50 Iafrancesco M, Goebel N, Mascaro J. et al; International E-vita Open Registry Group. Aortic diameter remodelling after the frozen elephant trunk technique in aortic dissection: results from an international multicentre registry. Eur J Cardiothorac Surg 2017; 52 (02) 310-318
  • 51 Jakob H, Tsagakis K, Tossios P. et al. Combining classic surgery with descending stent grafting for acute DeBakey type I dissection. Ann Thorac Surg 2008; 86 (01) 95-101
  • 52 Inoue Y, Matsuda H, Omura A. et al. Comparative study of the frozen elephant trunk and classical elephant trunk techniques to supplement total arch replacement for acute type A aortic dissection†. Eur J Cardiothorac Surg 2019; 56 (03) 579-586
  • 53 Kaneyuki D, Mogi K, Watanabe H, Otsu M, Sakurai M, Takahara Y. The frozen elephant trunk technique for acute retrograde type A aortic dissection: preliminary results. Interact Cardiovasc Thorac Surg 2020; 31 (06) 813-819
  • 54 Yoshitake A, Tochii M, Tokunaga C. et al. Early and long-term results of total arch replacement with the frozen elephant trunk technique for acute type A aortic dissection. Eur J Cardiothorac Surg 2020; 58 (04) 707-713
  • 55 Matsuzaki Y, Yamasaki T, Hohri Y, Hiramatsu T. Surgical strategies for type B aortic dissection by frozen elephant Trunk. Ann Vasc Dis 2019; 12 (04) 473-479
  • 56 Weiss G, Tsagakis K, Jakob H. et al. The frozen elephant trunk technique for the treatment of complicated type B aortic dissection with involvement of the aortic arch: multicentre early experience. Eur J Cardiothorac Surg 2015; 47 (01) 106-114 , discussion 114
  • 57 Subramanian S, Roselli EE. Thoracic aortic dissection: long-term results of endovascular and open repair. Semin Vasc Surg 2009; 22 (02) 61-68
  • 58 Fattori R, Bacchi-Reggiani L, Bertaccini P. et al. Evolution of aortic dissection after surgical repair. Am J Cardiol 2000; 86 (08) 868-872
  • 59 Immer FF, Krähenbühl E, Hagen U. et al. Large area of the false lumen favors secondary dilatation of the aorta after acute type A aortic dissection. Circulation 2005; 112 (09) I249-I252
  • 60 Rylski B, Milewski RK, Bavaria JE. et al. Outcomes of surgery for chronic type A aortic dissection. Ann Thorac Surg 2015; 99 (01) 88-93
  • 61 Luo C, Qi R, Zhong Y. et al. Early and long-term follow-up for chronic type B and type non-A non-B aortic dissection using the frozen elephant trunk technique. Front Cardiovasc Med 2021; 8: 714638
  • 62 Beckmann E, Martens A, Korte W. et al. Open total arch replacement with trifurcated graft and frozen elephant trunk. Ann Cardiothorac Surg 2020; 9 (03) 170-177
  • 63 Kreibich M, Siepe M, Berger T. et al. The frozen elephant trunk technique for the treatment of type B and type non-A non-B aortic dissection. Eur J Vasc Endovasc Surg 2021; 61 (01) 107-113
  • 64 Chen Y, Ma WG, Li JR. et al. Is the frozen elephant trunk technique justified for chronic type A aortic dissection in Marfan syndrome?. Ann Cardiothorac Surg 2020; 9 (03) 197-208
  • 65 Charchyan E, Breshenkov D, Belov Y. Follow-up outcomes after the frozen elephant trunk technique in chronic type B dissection. Eur J Cardiothorac Surg 2020; 57 (05) 904-911
  • 66 Yamane Y, Katayama K, Furukawa T. et al. Mid-term results of frozen elephant trunk technique for chronic aortic dissection. Ann Vasc Dis 2020; 13 (02) 137-143
  • 67 Berger T, Kreibich M, Morlock J. et al. True-lumen and false-lumen diameter changes in the downstream aorta after frozen elephant trunk implantation. Eur J Cardiothorac Surg 2018; 54 (02) 375-381
  • 68 Coselli JS, LeMaire SA, Carter SA, Conklin LD. The reversed elephant trunk technique used for treatment of complex aneurysms of the entire thoracic aorta. Ann Thorac Surg 2005; 80 (06) 2166-2172 , discussion 2172
  • 69 Ando M, Takamoto S, Okita Y, Morota T, Matsukawa R, Kitamura S. Elephant trunk procedure for surgical treatment of aortic dissection. Ann Thorac Surg 1998; 66 (01) 82-87
  • 70 Schepens MA, Dossche KM, Morshuis WJ, van den Barselaar PJ, Heijmen RH, Vermeulen FE. The elephant trunk technique: operative results in 100 consecutive patients. Eur J Cardiothorac Surg 2002; 21 (02) 276-281
  • 71 Svensson LG, Kim KH, Blackstone EH. et al. Elephant trunk procedure: newer indications and uses. Ann Thorac Surg 2004; 78 (01) 109-116
  • 72 LeMaire SA, Carter SA, Coselli JS. The elephant trunk technique for staged repair of complex aneurysms of the entire thoracic aorta. Ann Thorac Surg 2006; 81 (05) 1561-1569 , discussion 1569
  • 73 Aftab M, Idrees JJ, Cikach F, Navia JL, Hammer D, Roselli EE. Open distal fenestration of chronic dissection facilitates endovascular elephant trunk completion: late outcomes. Ann Thorac Surg 2017; 104 (06) 1960-1967
  • 74 Roselli EE, Bakaeen FG, Johnston DR, Soltesz EG, Tong MZ. Role of the frozen elephant trunk procedure for chronic aortic dissection. Eur J Cardiothorac Surg 2017; 51 (Suppl. 01) i35-i39
  • 75 Roselli EE, Sepulveda E, Pujara AC, Idrees J, Nowicki E. Distal landing zone open fenestration facilitates endovascular elephant trunk completion and false lumen thrombosis. Ann Thorac Surg 2011; 92 (06) 2078-2084
  • 76 Kim JB, Sundt III TM. Best surgical option for arch extension of type B aortic dissection: the open approach. Ann Cardiothorac Surg 2014; 3 (04) 406-412
  • 77 Sun L, Zhao X, Chang Q. et al. Repair of chronic type B dissection with aortic arch involvement using a stented elephant trunk procedure. Ann Thorac Surg 2010; 90 (01) 95-100
  • 78 Pacini D, Tsagakis K, Jakob H. et al. The frozen elephant trunk for the treatment of chronic dissection of the thoracic aorta: a multicenter experience. Ann Thorac Surg 2011; 92 (05) 1663-1670 , discussion 1670
  • 79 Di Eusanio M, Armaro A, Di Marco L. et al. Short- and midterm results after hybrid treatment of chronic aortic dissection with the frozen elephant trunk technique. Eur J Cardiothorac Surg 2011; 40 (04) 875-880
  • 80 Rustum S, Beckmann E, Wilhelmi M. et al. Is the frozen elephant trunk procedure superior to the conventional elephant trunk procedure for completion of the second stage?. Eur J Cardiothorac Surg 2017; 52 (04) 725-732
  • 81 Weiss G, Santer D, Dumfarth J. et al. Evaluation of the downstream aorta after frozen elephant trunk repair for aortic dissections in terms of diameter and false lumen status. Eur J Cardiothorac Surg 2016; 49 (01) 118-124
  • 82 Fattouch K, Sampognaro R, Navarra E. et al. Long-term results after repair of type a acute aortic dissection according to false lumen patency. Ann Thorac Surg 2009; 88 (04) 1244-1250
  • 83 Chen Y, Ma W-G, Zhi A-H. et al. Fate of distal aorta after frozen elephant trunk and total arch replacement for type A aortic dissection in Marfan syndrome. J Thorac Cardiovasc Surg 2019; 157 (03) 835-849
  • 84 Idrees JJ, Roselli EE, Wojnarski CM. et al. Prophylactic stage 1 elephant trunk for moderately dilated descending aorta in patients with predominantly proximal disease. J Thorac Cardiovasc Surg 2015; 150 (05) 1150-1155
  • 85 Rezaei Y, Bashir M, Mousavizadeh M. et al. Frozen elephant trunk in total arch replacement: A systematic review and meta-analysis of outcomes and aortic proximalization. J Card Surg 2021; 36 (06) 1922-1934
  • 86 Yamamoto H, Kadohama T, Yamaura G. et al. Total arch repair with frozen elephant trunk using the “zone 0 arch repair” strategy for type A acute aortic dissection. J Thorac Cardiovasc Surg 2019; S0022-5223 (19)30360-5
  • 87 Tsagakis K, Wendt D, Dimitriou AM. et al. The frozen elephant trunk treatment is the operation of choice for all kinds of arch disease. J Cardiovasc Surg (Torino) 2018; 59 (04) 540-546
  • 88 Gkremoutis A, Zierer A, Schmitz-Rixen T. et al. Staged treatment of mega aortic syndrome using the frozen elephant trunk and hybrid thoracoabdominal repair. J Thorac Cardiovasc Surg 2017; 154 (06) 1842-1849
  • 89 Folkmann S, Weiss G, Pisarik H, Czerny M, Grabenwoger M. Thoracoabdominal aortic aneurysm repair after frozen elephant trunk procedure. Eur J Cardiothorac Surg 2015; 47 (01) 115-119 , discussion 119
  • 90 Svensson LG, Kouchoukos NT, Miller DC. et al; Society of Thoracic Surgeons Endovascular Surgery Task Force. Expert consensus document on the treatment of descending thoracic aortic disease using endovascular stent-grafts. Ann Thorac Surg 2008; 85 (01) S1-S41
  • 91 Chen SW, Zhong YL, Ge YP. et al. Successful repair of acute type A aortic dissection during pregnancy at 16th gestational week with maternal and fetal survival: A case report and review of the literature. World J Clin Cases 2019; 7 (18) 2843-2850
  • 92 Tian DH, Wan B, Di Eusanio M, Black D, Yan TD. A systematic review and meta-analysis on the safety and efficacy of the frozen elephant trunk technique in aortic arch surgery. Ann Cardiothorac Surg 2013; 2 (05) 581-591