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CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(05): s00441786853
DOI: 10.1055/s-0044-1786853
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Neurogenesis and pesticides: news of no new neurons

Neurogênese e pesticidas: a ausência de novos neurônios é a novidade
Fulvio A. Scorza 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia, Disciplina de Neurologia, São Paulo SP, Brazil.
2   Ministério do Desenvolvimento Agrário e Agricultura Familiar, São Paulo SP, Brazil.
,
Antonio-Carlos G. de Almeida 
3   Universidade Federal de São João del-Rei, Departamento de Engenharia de Biossistemas, Laboratório de Neurociência Experimental e Computacional, São João del-Rei MG, Brazil.
,
Ana C. Fiorini 
4   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Fonoaudiologia, São Paulo SP, Brazil.
5   Pontifícia Universidade Católica de São Paulo, Programa de Estudos Pós-Graduado em Fonoaudiologia, São Paulo SP, Brazil.
,
Feres Chaddad-Neto 
6   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brazil.
7   Hospital Beneficência Portuguesa, Unidade de Neurocirurgia, São Paulo SP, Brazil.
,
Josef Finsterer 
8   Neurology and Neurophysiology Center, Vienna, Austria.
› Author Affiliations Support This work was supported by the Brazilian agencies Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Programa Nacional de Cooperação Academica/Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (PROCAD/CAPES), and Instituto Nacional de Neurociência Translacional (INNT) of Translational Neuroscience (Ministério da Ciência e Tecnologia/CNPq/FAPESP).
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Abstract

New hippocampal neurons are continuously generated in the adult human brain. Several studies have demonstrated that the proliferation of hippocampal cells is strongly influenced by a variety of stimuli, including pesticides exposure. These effects are particularly important because neurogenesis dysregulation could be associated with the decline of neuronal and cognitive functions and the possible development of neuropsychiatric disorders.

Resumo

Novos neurônios hipocampais são gerados continuamente no cérebro humano adulto. Vários estudos têm demonstrado que a proliferação de células do hipocampo é influenciada por uma variedade de estímulos, incluindo a exposição a pesticidas. Estes efeitos são particularmente importantes porque a desregulação da neurogênese pode estar associada ao declínio das funções neuronais e cognitivas e ao possível desenvolvimento de doenças neuropsiquiátricas.

Keywords

Neurogenesis - Pesticides - Neuronal Plasticity - Brain

Palavras-chave

Neurogênese - Praguicidas - Plasticidade Neuronal - Encéfalo

Authors' Contributions

FAS: conceptualization, investigation, and writing – review & editing; ACGA: writing – review & editing; ACF: supervision and writing – review & editing; FCN and JF: writing – review & editing.




Publication History

Received: 12 December 2023

Accepted: 09 March 2024

Article published online:
19 May 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Fulvio A. Scorza, Antonio-Carlos G. de Almeida, Ana C. Fiorini, Feres Chaddad-Neto, Josef Finsterer. Neurogenesis and pesticides: news of no new neurons. Arq Neuropsiquiatr 2024; 82: s00441786853.
DOI: 10.1055/s-0044-1786853
 

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