An Adult Case of Medulloblastoma with Multiple Lung Metastatic Lesions—Case Report and Literature Review

Abstract

Medulloblastoma (MB) cerebelli is a common brain tumor of the childhood. MB commonly spreads through cerebrospinal fluid; however, there are several reported cases of extracranial spread. The most common sites of extracranial metastasis are bones and bone marrow followed by peritoneum, liver, and lungs. Here, we report a case of pulmonary metastatic lesions of adult cerebellar MB that were discovered 1 year after the primary surgical treatment. We also tried to highlight similar reported cases in the literature.

Keywords

medulloblastoma - adult - leptomeningeal spread - lung metastasis

• References

• 1 Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015. Neuro oncol 2018 20(suppl_4):iv1–iv86. Erratum in: Neuro Oncol. 2018
• 2 Giordana MT, Schiffer P, Lanotte M, Girardi P, Chio A. Epidemiology of adult medulloblastoma. Int J Cancer 1999; 80 (05) 689-692
• 3 Johnston DL, Keene D, Kostova M. et al. Incidence of medulloblastoma in Canadian children. J Neurooncol 2014; 120 (03) 575-579
• 4 Roberts RO, Lynch CF, Jones MP, Hart MN. Medulloblastoma: a population-based study of 532 cases. J Neuropathol Exp Neurol 1991; 50 (02) 134-144
• 5 Duffner PK, Cohen ME. Extraneural metastases in childhood brain tumors. Ann Neurol 1981; 10 (03) 261-265
• 6 Varan A, Sari N, Akalan N. et al. Extraneural metastasis in intracranial tumors in children: the experience of a single center. J Neurooncol 2006; 79 (02) 187-190
• 7 Rickert CH. Extraneural metastases of paediatric brain tumours. Acta Neuropathol 2003; 105 (04) 309-327
• 8 Campbell AN, Chan HS, Becker LE, Daneman A, Park TS, Hoffman HJ. Extracranial metastases in childhood primary intracranial tumors. A report of 21 cases and review of the literature. Cancer 1984; 53 (04) 974-981
• 9 Mazloom A, Zangeneh AH, Paulino AC. Prognostic factors after extraneural metastasis of medulloblastoma. Int J Radiat Oncol Biol Phys 2010; 78 (01) 72-78
• 10 Pasquier B, Pasquier D, N'Golet A, Panh MH, Couderc P. Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of literature. Cancer 1980; 45 (01) 112-125
• 11 Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R. Medulloblastomas in adults: prognostic factors and lessons from paediatrics. Curr Opin Neurol 2011; 24 (06) 626-632
• 12 Thomas A, Noël G. Medulloblastoma: optimizing care with a multidisciplinary approach. J Multidiscip Healthc 2019; 12: 335-347
• 13 Remke M, Hielscher T, Northcott PA. et al. Adult medulloblastoma comprises three major molecular variants. J Clin Oncol 2011; 29 (19) 2717-2723
• 14 Eberhart CG, Cohen KJ, Tihan T, Goldthwaite PT, Burger PC. Medulloblastomas with systemic metastases: evaluation of tumor histopathology and clinical behavior in 23 patients. J Pediatr Hematol Oncol 2003; 25 (03) 198-203
• 15 Mobark NA, Al-Harbi M, Mosleh O, Santagata S, Snuderl M, Abedalthagafi M. A case of molecularly profiled extraneural medulloblastoma metastases in a child. BMC Med Genet 2018; 19 (01) 10
• 16 Packer RJ, Gajjar A, Vezina G. et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 2006; 24 (25) 4202-4208
• 17 Kumar S, Handa A, Jha DK, Choudhary A. Supratentorial metastasis of medulloblastoma in adults. Asian J Neurosurg 2016; 11 (03) 320
• 18 Ghose A, Morris JC, Breneman JC, Essell J, Wang J, Benzaquen S. Medulloblastoma in an adult with late extraneural metastases to the mediastinum. J Investig Med High Impact Case Rep 2014; 2 (02) 23 24709614532798
• 19 Kochbati L, Bouaouina N, Hentati D. et al. Medulloblastoma with extracentral nervous system metastases: clinical presentation and risk factors [in French]. Cancer Radiother 2006; 10 (03) 107-111
• 20 Makeever LC, King JD. Medulloblastoma with extracranial metastasis through a ventriculovenous shunt. Report of a case and review of the literature. Am J Clin Pathol 1966; 46 (02) 245-249
• 21 Smith DR, Hardman JM, Earle KM. Metastasizing neuroectodermal tumors of the central nervous system. J Neurosurg 1969; 31 (01) 50-58
• 22 Komatsu S, Sato T, Katakura R, Sakurai Y, Wada T, Namiki T. [Pulmonary metastasis from cerebellar medulloblastoma–report of a case and review of the cases in the literature (author's transl)]. No Shinkei Geka 1980; 8 (02) 187-191
• 23 Kato S, Aoki H, Tamura K, Hayashi H, Miyata H, Hori T, Ohama E. Massive lung metastasis from cerebellar medulloblastoma: a report on one case and review of literature. Yonago Acta Med 1997; 40: 63-72
• 24 Paulino AC, Mazloom A, Teh BS. et al. Local control after craniospinal irradiation, intensity-modulated radiotherapy boost, and chemotherapy in childhood medulloblastoma. Cancer 2011; 117 (03) 635-641