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CC BY-NC-ND 4.0 · Indian J Radiol Imaging
DOI: 10.1055/s-0044-1787159
Original Article

Compliance with Low-Dose Aspirin and Outcomes in High-Risk Pregnant Women in Guna District of Central India

Lalit K. Sharma
1   Department of Social Radiology, Raj Sonography and X- Ray Clinic, Guna, Madhya Pradesh, India
,
Rijo M. Choorakuttil
2   Department of Preventive Radiology and Integrated Diagnostics, AMMA Scans-Center for Diagnosis and Preventive Medicine Pvt Ltd, Kochi, Kerala, India
,
Praveen K. Nirmalan 
3   Department of Research, AMMA Scans-Center for Diagnosis and Preventive Medicine Pvt Ltd, Kochi, Kerala, India
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Abstract

Aim This article determines the compliance rates with low-dose aspirin (LDA) and outcomes in a group of pregnant women identified at high risk for preeclampsia (PE) and fetal growth restriction (FGR) at 11 to 14 gestational weeks (GWs) in a rural district of central India.

Methods A single, experienced fetal radiologist assessed all enrolled pregnant women using trimester-specific antenatal screening protocols that included mean arterial blood pressure assessment, and fetal ultrasound and Doppler studies. A trimester-specific individualized risk for preterm PE and FGR was estimated for each woman. Pregnant women categorized as high risk for preterm PE or FGR based on a 1 in 150 criteria at 11 to 14 GW were recommended LDA 150 mg once daily at bedtime. Outcome measures included compliance with LDA assessed, incidence of PE and FGR, preterm delivery (< 37 GW), birth weight, stillbirths, and perinatal mortality.

Results The data of 488 pregnant women with longitudinal trimester-specific assessments from 11 to 14 GW till childbirth was analyzed. At the 3rd trimester assessment, 215 (80.83%) of the high-risk women were compliant with LDA. The incidence of PE, FGR, and preterm births was significantly higher in LDA noncompliant women, and the mean birth weight was significantly higher in LDA-compliant high-risk women.

Conclusion Good compliance for LDA is possible in rural populations with adequate counseling. Starting LDA at 11 to 14 GW for high-risk pregnant women lowered the incidence of PE, FGR, and preterm birth rates and improved birth weight in the study population.

Keywords

compliance - fetal growth restriction - low-dose aspirin - preeclampsia - preterm births

Note

This work is attributed to Indian Radiological & Imaging Association, IRIA House, C-5, Qutab Institutional Area, New Delhi 110016, India.




Publication History

Article published online:
06 June 2024

© 2024. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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