Long-Term Neurodevelopmental Outcomes in Children with Gastroschisis: A Review of the Literature

Abstract

This study aimed to investigate and present a review of the literature on long-term neurodevelopmental outcomes in children with gastroschisis. Gastroschisis is the most common abdominal wall defect. Children with gastroschisis are at high risk for premature birth, intestinal failure, sepsis, and repeated anesthesia exposure, which collectively increase the risk for adverse long-term neurodevelopmental outcomes. The existing literature on neurodevelopmental outcomes is limited in number, quality, and generalizability, creating a gap in clinical knowledge and care. Five internet databases were searched by a professional research librarian: Ovid MEDLINE, Scopus, Web of Science, PsycINFO, and Cochrane Library. Included articles were (1) published in English, (2) included postneonatal hospital discharge neurodevelopmental outcomes of children with gastroschisis, and (3) included patients under the age of 18 years. No date parameters were applied. The paucity of literature on long-term neurodevelopmental outcomes in gastroschisis children has left large gaps in the body of knowledge on post-hospital care of such children. In this review, 37 articles were found evaluating neurodevelopmental outcomes in gastroschisis and, while conclusions were contradictory, the literature broadly indicated the potential for neurodevelopmental deficits in the gastroschisis pediatric population. A significant limitation of this review was the heterogeneous samples included in available literature, which confounded the ability to determine cognitive risk of gastroschisis independent of other abdominal wall defects. Findings of this review demonstrate potential risk for neurodevelopmental deficits in the pediatric gastroschisis population exist, yet additional research is needed to definitively predict the significance, type, onset, and trajectory of neurodevelopmental impairment in this population. The significant gaps in long-term outcomes data have elucidated the need for prospective, longitudinal investigation of various cognitive domains in homogenous gastroschisis populations to properly evaluate prevalence of neurodevelopmental deficits and guide recommendations for long-term clinical care.

Key Points

• Limited literature exists regarding long-term neurodevelopmental outcomes in gastroschisis.

• There is some evidence to suggest worse cognitive behavioral outcomes in gastroschisis over time.

• Developmental surveillance, screening, and evaluation may be beneficial for gastroschisis patients.

Keywords

gastroschisis - neurodevelopment - long-term evaluation - follow-up - cognitive

Note

A protocol was not prepared nor registered for this review. The review was registered at PROSPERO, ID CRD42023430491. All information collected and data extracted have been included in this manuscript. Search strategies are publicly available in the PROSPERO registration CRD42023430491.

Publication History

Received: 26 March 2024

Accepted: 02 May 2024

Article published online:
29 May 2024

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