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CC BY 4.0 · Chinese medicine and natural products 2024; 04(02): e49-e55
DOI: 10.1055/s-0044-1787649
Review Article

Research Progress on Chinese Medicine Regulation of Mitochondrial Damage for Intervention in Respiratory System Diseases

Haibo Li
1   Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R. China, Zhengzhou, Henan, China
2   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Jingfan Yang
1   Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R. China, Zhengzhou, Henan, China
2   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Yanqin Qin
1   Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R. China, Zhengzhou, Henan, China
2   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Tiantian Liu
1   Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P.R. China, Zhengzhou, Henan, China
2   Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China
› Author Affiliations Funding This work was supported by the National Natural Science Foundation of China (82104662), Science and Technology Research Key Project of Henan Province (222102310141, 232102310435) and Postdoctoral Research Project of Henan Province (202101046)
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Abstract

Mitochondria are important organelles in cells for energy production, and mitochondrial damage caused by various reasons is an important factor promoting disease progression. Mitochondrial damage involves structural damage and mitochondrial DNA damage, which are closely related to the occurrence and development of respiratory system diseases. In recent years, a large number of studies have confirmed the significant role of mitochondrial damage in the progression of respiratory system diseases, which may be an important target for the treatment of respiratory system diseases with traditional Chinese medicine (TCM). This article reviews the role of TCM in regulating mitochondrial damage for intervention in respiratory system diseases such as chronic obstructive pulmonary disease, lung cancer, pulmonary fibrosis, acute lung injury, asthma, and pneumonia, aiming to provide a basis for the study of the pathogenesis and drug action targets of respiratory system diseases.

Keywords

mitochondrial damage - respiratory system diseases - TCM

CRediT Authorship Contribution Statement

Haibo Li: Writing—original draft, and investigation. Jingfan Yang: Investigation. Yanqin Qin: Conceptualization, writing—review and editing, and funding acquisition. Tiantian Liu: Writing—review and editing.




Publication History

Received: 12 February 2024

Accepted: 24 April 2024

Article published online:
27 June 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Al Amir Dache Z, Thierry AR. Mitochondria-derived cell-to-cell communication. Cell Rep 2023; 42 (07) 112728
    CrossrefPubMedGoogle Scholar
  • 2 Baker MJ, Crameri JJ, Thorburn DR, Frazier AE, Stojanovski D. Mitochondrial biology and dysfunction in secondary mitochondrial disease. Open Biol 2022; 12 (12) 220274
    CrossrefPubMedGoogle Scholar
  • 3 Maremanda KP, Sundar IK, Rahman I. Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD. Redox Biol 2021; 45: 102055
    CrossrefPubMedGoogle Scholar
  • 4 Wang M, Zhang Y, Xu M. et al. Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model. Free Radic Biol Med 2019; 134: 229-238
    CrossrefPubMedGoogle Scholar
  • 5 Mazzoccoli G, Kvetnoy I, Mironova E. et al. The melatonergic pathway and its interactions in modulating respiratory system disorders. Biomed Pharmacother 2021; 137: 111397
    CrossrefPubMedGoogle Scholar
  • 6 Ye L, Zeng Q, Ling M. et al. Inhibition of IP3R/Ca2+ dysregulation protects mice from ventilator-induced lung injury via endoplasmic reticulum and mitochondrial pathways. Front Immunol 2021; 12: 729094
    CrossrefPubMedGoogle Scholar
  • 7 Zhou JS, Zhao Y, Zhou HB. et al. Autophagy plays an essential role in cigarette smoke-induced expression of MUC5AC in airway epithelium. Am J Physiol Lung Cell Mol Physiol 2016; 310 (11) L1042-L1052
    CrossrefPubMedGoogle Scholar
  • 8 Jin J, Huang MX, Ma HY. et al. Research progress of mitochondrial damage in pathogenesis of chronic obstructive pulmonary disease. Chin Modern Doctor 2023; 9 (07) 91-95
    Google Scholar
  • 9 Casas-Recasens S, Mendoza N, López-Giraldo A. et al. Telomere length but not mitochondrial DNA copy number is altered in both young and old COPD. Front Med (Lausanne) 2021; 8: 761767
    CrossrefPubMedGoogle Scholar
  • 10 Agustí A, Vogelmeier C, Faner R. COPD 2020: changes and challenges. Am J Physiol Lung Cell Mol Physiol 2020; 319 (05) L879-L883
    CrossrefPubMedGoogle Scholar
  • 11 Ahmad Hassali MA, Muhammad SA, Shah S, Abbas S, Hyder Ali IAB, Salman A. Anees Ur Rehman. The economic burden of chronic obstructive pulmonary disease (COPD) in the USA, Europe, and Asia: results from a systematic review of the literature. Expert Rev Pharmacoecon Outcomes Res 2020; 20 (06) 661-672
    CrossrefPubMedGoogle Scholar
  • 12 López-Campos JL, Tan W, Soriano JB. Global burden of COPD. Respirology 2016; 21 (01) 14-23
    CrossrefPubMedGoogle Scholar
  • 13 Harrington JS, Ryter SW, Plataki M, Price DR, Choi AMK. Mitochondria in health, disease, and aging. Physiol Rev 2023; 103 (04) 2349-2422
    CrossrefPubMedGoogle Scholar
  • 14 Mizumura K, Cloonan SM, Nakahira K. et al. Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest 2014; 124 (09) 3987-4003
    CrossrefPubMedGoogle Scholar
  • 15 Yao CY, Luo H. Protective effect of salidroside on lung injury in rats with acute respiratory distress syndrome. Chin J Clin Pharmacol 2020; 36 (07) 782-784 , 788
    Google Scholar
  • 16 Zhang D, Cao LH, Wang ZS. et al. Effect of salidroside on skeletal muscle function in rats with chronic obstructive pulmonary disease induced by cigarette smoke. Dalian Yike Daxue Xuebao 2019; 41 (03) 199-204 , 209
    Google Scholar
  • 17 Liu L, Zhang Y, Wang L. et al. Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase. Phytother Res 2023; 37 (10) 4587-4606
    CrossrefPubMedGoogle Scholar
  • 18 Liu YC, Wang YF, Zhao LJ. et al. Research progress of Sijunzi Decoction and supplemented formula in treatment of non-small cell lung cancer. J Pharm Res 2022; 8 (10) 683-685 , 689
    Google Scholar
  • 19 Hu T, Zhou XY, Xue D. et al. Repair effect of supplemented Sijunzi Decoction on diaphragm mitochondrial injury in mice with chronic obstructive pulmonary disease. J Guangzhou Univ Tradit Chin Med 2020; 37 (03) 523-527
    Google Scholar
  • 20 Dong Y, Li Y, Sun Y. et al. Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease. BMC Complement Altern Med 2015; 15: 51
    CrossrefPubMedGoogle Scholar
  • 21 Chen WC, Chen YF, Li FS. Research progress in the treatment of chronic obstructive pulmonary disease by cultivating earth cultivation to generate gold. World Chin Med 2024; 19 (01) 133-138
    Google Scholar
  • 22 Feng LZ, Zhan SF. Effects of earth cultivation on pathological morphology of alveoli, diaphragm and mitochondria in chronic obstructive pulmonary disease rats. J Guangzhou Univ Tradit Chin Med 2022; 8 (09) 2123-2128
    Google Scholar
  • 23 Bade BC, Dela Cruz CS. Lung cancer 2020: epidemiology, etiology, and prevention. Clin Chest Med 2020; 41 (01) 1-24
    CrossrefPubMedGoogle Scholar
  • 24 Marchi S, Guilbaud E, Tait SWG, Yamazaki T, Galluzzi L. Mitochondrial control of inflammation. Nat Rev Immunol 2023; 23 (03) 159-173
    CrossrefPubMedGoogle Scholar
  • 25 Inigo JR, Chandra D. The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer. J Hematol Oncol 2022; 15 (01) 98
    CrossrefPubMedGoogle Scholar
  • 26 Wang JM, Fu XZ, Qu GW. et al. Determination of related substances in 20(S)-protopanaxanediol by HPLC. Chin J Mod Appl Pharm 2023; 40 (18) 2562-2568
    Google Scholar
  • 27 Li QY, Peng Y. et al. Inhibitory effect and mechanism of propanaxanediol on non-small cell lung cancer. Chin J Clin Pharmacol Thera 2020; 36 (22) 3657-3660
    Google Scholar
  • 28 Li D, Dong MG, Fang ZK. et al. Effects of fangchinoline on biological behavior of prostate cancer PC3 cells based on mitochondrial apoptosis pathway. J Hunan Univ Chin Med 2023; 43 (07) 1194-1200
    Google Scholar
  • 29 Lai XH, Xie MJ, Chen HY. et al. Research progress on chemical composition and pharmacological activities of Fangii (Stephaniae Tetrandrae Radix) and predictive analysis on Q-marker. Chin Arch Trad Chin Med 2023; 9 (03) 244-252
    Google Scholar
  • 30 Chen B, Song Y, Zhan Y. et al. Fangchinoline inhibits non-small cell lung cancer metastasis by reversing epithelial-mesenchymal transition and suppressing the cytosolic ROS-related Akt-mTOR signaling pathway. Cancer Lett 2022; 543: 215783
    CrossrefPubMedGoogle Scholar
  • 31 Adnan M, Rasul A, Hussain G. et al. Ginkgetin: a natural biflavone with versatile pharmacological activities. Food Chem Toxicol 2020; 145: 111642
    CrossrefPubMedGoogle Scholar
  • 32 Lou JS, Zhao LP, Huang ZH. et al. Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. Phytomedicine 2021; 80: 153370
    CrossrefPubMedGoogle Scholar
  • 33 Moss BJ, Ryter SW, Rosas IO. Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu Rev Pathol 2022; 17: 515-546
    CrossrefPubMedGoogle Scholar
  • 34 Schuliga M, Kanwal A, Read J. et al. A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF. Am J Physiol Lung Cell Mol Physiol 2021; 321 (05) L859-L871
    CrossrefPubMedGoogle Scholar
  • 35 Han S, Lee M, Shin Y. et al. Mitochondrial integrated stress response controls lung epithelial cell fate. Nature 2023; 620 (7975) 890-897
    CrossrefPubMedGoogle Scholar
  • 36 Selvarajah B, Azuelos I, Anastasiou D, Chambers RC. Fibrometabolism—an emerging therapeutic frontier in pulmonary fibrosis. Sci Signal 2021; 14 (697) eaay1027
    CrossrefPubMedGoogle Scholar
  • 37 Ke S, Zhu W, Lan Z. et al. Cinnamaldehyde regulates mitochondrial quality against hydrogen peroxide induced apoptosis in mouse lung mesenchymal stem cells via the PINK1/Parkin signaling pathway. PeerJ 2022; 10: e14045
    CrossrefPubMedGoogle Scholar
  • 38 Gu X, Long Q, Wei W. et al. Number 2 Feibi recipe inhibits H2O2-mediated oxidative stress damage of alveolar epithelial cells by regulating the balance of mitophagy/apoptosis. Front Pharmacol 2022; 13: 830554
    CrossrefPubMedGoogle Scholar
  • 39 Xu YQ, Guo YM, Gao JH. Promoting effect of naringin on airway inflammatory cell apoptosis in asthmatic mice and its mechanism. Mod Trad Chin Med Mater Med World Sci Technol 2024; 26 (03) 742-750
    Google Scholar
  • 40 Wei Y, Sun L, Liu C, Li L. Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate pulmonary fibrosis. Naunyn Schmiedebergs Arch Pharmacol 2023; 396 (06) 1155-1169
    CrossrefPubMedGoogle Scholar
  • 41 Raghavendran K, Napolitano LM. Definition of ALI/ARDS. Crit Care Clin 2011; 27 (03) 429-437
    CrossrefPubMedGoogle Scholar
  • 42 Long G, Gong R, Wang Q, Zhang D, Huang C. Role of released mitochondrial DNA in acute lung injury. Front Immunol 2022; 13: 973089
    CrossrefPubMedGoogle Scholar
  • 43 Li XM, Zang CC, Guo YL. et al. Comparison of the in vitro effects of Qingfei Paidu Decoction, Huashi Baidy Decoction and Xuanfei Baidu Decoctionagainst complement activation. Pharmacol Clin Chin Mater Med. Online 2024-05-3. Available at: URL: http://doi.org/10.13412/j.cnki.zyyl.20240301.001
    Google Scholar
  • 44 Li Z, Pan H, Yang J. et al. Xuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models. Phytomedicine 2023; 108: 154545
    CrossrefPubMedGoogle Scholar
  • 45 Zhang L, Li JY, Xu SQ. et al. Research progress in molecular pharmacognosy of Andrographis paniculata. Chin J Chin Mater Med. Online 2024-05-3. Available at: URL:https://doi.org/10.19540/j.cnki.cjcmm.20240412.101
    Google Scholar
  • 46 Pu Z, Sui B, Wang X, Wang W, Li L, Xie H. The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis. Phytomedicine 2023; 114: 154753
    CrossrefPubMedGoogle Scholar
  • 47 Singh B, Singh JP, Kaur A, Singh N. Phenolic composition, antioxidant potential and health benefits of citrus peel. Food Res Int 2020; 132: 109114
    CrossrefPubMedGoogle Scholar
  • 48 Liu Y, Zhang Y, You G. et al. Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis. Inflamm Res 2024; 73 (01) 47-63
    CrossrefPubMedGoogle Scholar
  • 49 Mao JT, Xu LM, Cao M. et al. Protective effects of baicalin regulating NLRP3 inflammasome against acne. Chin J Clin Pharmacol 2024; 40 (07) 1039-1043
    Google Scholar
  • 50 Jiang C, Zhang J, Xie H. et al. Baicalein suppresses lipopolysaccharide-induced acute lung injury by regulating Drp1-dependent mitochondrial fission of macrophages. Biomed Pharmacother 2022; 145: 112408
    CrossrefPubMedGoogle Scholar
  • 51 Sockrider M, Fussner L. What is asthma?. Am J Respir Crit Care Med 2020; 202 (09) 25-P26
    CrossrefPubMedGoogle Scholar
  • 52 Caldeira DAF, Weiss DJ, Rocco PRM, Silva PL, Cruz FF. Mitochondria in focus: from function to therapeutic strategies in chronic lung diseases. Front Immunol 2021; 12: 782074
    CrossrefPubMedGoogle Scholar
  • 53 Zhao L, Gao J, Chen G. et al. Mitochondria dysfunction in airway epithelial cells is associated with type 2-low asthma. Front Genet 2023; 14: 1186317
    CrossrefPubMedGoogle Scholar
  • 54 Xia TT, Peng QM, Zeng KF. et al. Effects of apigenin on ovarian function in rats with polycystic ovary syndrome by regulating ERK/Nrf2/HO-1 signaling pathway. Zhongchengyao 2024; 46 (04) 1352-1356
    Google Scholar
  • 55 Yu H, Huang X, Zhu HH. et al. Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway. Phytomedicine 2023; 111: 154646
    CrossrefPubMedGoogle Scholar
  • 56 Li JW, Qin F, Song SQ. et al. Antagonistic effect of salidroside on podocyte pyroptosis in diabetic kidney disease rats under hypoxia based on LRP3/IL-1B/TGF-B1 Pathway. Chin Gen Pract 2024; 27 (21) 2617-2622
    Google Scholar
  • 57 Shan H, Li X, Ouyang C. et al. Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function. Ecotoxicol Environ Saf 2022; 231: 113170
    CrossrefPubMedGoogle Scholar
  • 58 Adki KM, Kulkarni YA. Chemistry, pharmacokinetics, pharmacology and recent novel drug delivery systems of paeonol. Life Sci 2020; 250: 117544
    CrossrefPubMedGoogle Scholar
  • 59 Zhang L, Li DC, Liu LF. Paeonol: pharmacological effects and mechanisms of action. Int Immunopharmacol 2019; 72: 413-421
    CrossrefPubMedGoogle Scholar
  • 60 Han X, Hu S, Yang Q, Sang X, Tang D, Cao G. Paeoniflorin ameliorates airway inflammation and immune response in ovalbumin induced asthmatic mice: from oxidative stress to autophagy. Phytomedicine 2022; 96: 153835
    CrossrefPubMedGoogle Scholar
  • 61 Cui J, Xu F, Tang Z. et al. Bu-Shen-Yi-Qi formula ameliorates airway remodeling in murine chronic asthma by modulating airway inflammation and oxidative stress in the lung. Biomed Pharmacother 2019; 112: 108694
    CrossrefPubMedGoogle Scholar
  • 62 Hespanhol V, Bárbara C. Pneumonia mortality, comorbidities matter?. Pulmonology 2020; 26 (03) 123-129
    CrossrefPubMedGoogle Scholar
  • 63 Medicine TLR. The Lancet Respiratory Medicine. Pneumonia research: time to fill in the gaps. Lancet Respir Med 2019; 7 (12) 993
    CrossrefPubMedGoogle Scholar
  • 64 Karim L, Kosmider B, Bahmed K. Mitochondrial ribosomal stress in lung diseases. Am J Physiol Lung Cell Mol Physiol 2022; 322 (04) L507-L517
    CrossrefPubMedGoogle Scholar
  • 65 Ten VS, Ratner V. Mitochondrial bioenergetics and pulmonary dysfunction: Current progress and future directions. Paediatr Respir Rev 2020; 34: 37-45
    PubMedGoogle Scholar
  • 66 Chen K, Yang R, Shen FQ, Zhu HL. Advances in pharmacological activities and mechanisms of glycyrrhizic acid. Curr Med Chem 2020; 27 (36) 6219-6243
    CrossrefPubMedGoogle Scholar
  • 67 Guan X, Jin L, Yu D. et al. Glycyrrhetinic acid prevents carbapenem-resistant Klebsiella pneumoniae-induced cell injury by inhibiting mitochondrial dysfunction via Nrf-2 pathway. Microb Pathog 2023; 177: 105825
    CrossrefPubMedGoogle Scholar
  • 68 Zhang W, Kang MJ, Gou XW. et al. Reconstruction of Chinese materia medica-Huanglian. Jilin J Chin Med 2024; 44 (04) 467-470
    Google Scholar
  • 69 Liu H, You L, Wu J. et al. Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS. J Leukoc Biol 2020; 108 (01) 253-266
    CrossrefPubMedGoogle Scholar
  • 70 Tian XR, Li XZ, Zhu J. et al. Effect of Tongfu Yigi Huoxue Decoction combined with alveolar lavage in the treatment of pneumonia sepsis and its influence on T lymphocyte subsets and mitochondrial damage index. Hainan Med J 2024; 35 (01) 29-34
    Google Scholar
  • 71 Johnson S, Sommer N, Cox-Flaherty K, Weissmann N, Ventetuolo CE, Maron BA. Pulmonary hypertension: a contemporary review. Am J Respir Crit Care Med 2023; 208 (05) 528-548
    CrossrefPubMedGoogle Scholar
  • 72 Pokharel MD, Garcia-Flores A, Marciano D. et al. Mitochondrial network dynamics in pulmonary disease: bridging the gap between inflammation, oxidative stress, and bioenergetics. Redox Biol 2024; 70: 103049
    CrossrefPubMedGoogle Scholar
  • 73 Zhang W, Liu B, Wang Y. et al. Mitochondrial dysfunction in pulmonary arterial hypertension. Front Physiol 2022; 13: 1079989
    CrossrefPubMedGoogle Scholar
  • 74 Liu SY, Shao L, Guo Q. et al. Protective effect of Pheretima extract on pulmonary arterial hypertension based on NLRP3 inflammasome activation. Chin Tradit Herbal Drugs 2022; 53 (02) 461-469
    Google Scholar
  • 75 Meng CH, Lu ML, Sui HJ. et al. Effect of honokiol on autophagy and apoptosis of cardiomyocytes induced by lipopolysaccharide. Pharmacol Clin Chin Mater Med:1–15
    Google Scholar
  • 76 Chen L, Li W, Wang D. [Honokiol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via activation of mitochondrion-dependent Sirt3/AMPK pathway]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018; 43 (10) 1075-1082 (Med Sci)
    PubMedGoogle Scholar
  • 77 Qi XM, Luo Y, Song MY. et al. Pneumoconiosis: current status and future prospects. Chin Med J (Engl) 2021; 134 (08) 898-907
    CrossrefPubMedGoogle Scholar
  • 78 Zheng L, Liu S, Guo R. et al. The effects of catalpol on proliferation, apoptosis and immune escape of lung cancer cells by regulating the cGAS-STING signaling pathway. J Mod Oncol 2024; 32 (08) 1417-1423
    Google Scholar
  • 79 Liu W, Zhao TT, Li CY. et al. Catalpol improves exercise ability and skeletal muscle function in pneumoconiosis rats. Yaowu Pingjia Yanjiu 2022; 8 (12) 2501-2508
    Google Scholar