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CC BY 4.0 · Rev Bras Ortop (Sao Paulo) 2024; 59(04): e526-e531
DOI: 10.1055/s-0044-1787767
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A estimulação elétrica previne a atrofia muscular e a diminuição da interleucina-6 em músculos paralisados após lesão da medula espinal em ratos

Article in several languages: português | English
Nicolas A. M. M. Machado-Pereira 
1   Núcleo de Pesquisa em Lesão da Medula Espinal (NULEME), Departamento de Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brasil
,
Patrícia S. do Nascimento 
2   Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde (CCS), Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brasil
,
Gabriel R. de Freitas 
1   Núcleo de Pesquisa em Lesão da Medula Espinal (NULEME), Departamento de Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brasil
,
Franciane Bobinski 
3   Laboratório Experimental de Neurociências (LANEX), Universidade do Sul de Santa Catarina (UNISUL), Palhoça, SC, Brasil
,
Caroline C. do Espírito Santo 
4   Instituto Internacional de Neurociências Edmond e Lily Safra (IIN-ELS), Macaíba, RN, Brasil
,
Jocemar Ilha 
1   Núcleo de Pesquisa em Lesão da Medula Espinal (NULEME), Departamento de Fisioterapia, Centro de Ciências da Saúde e do Esporte (CEFID), Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brasil
› Author Affiliations Suporte Financeiro Os autores declaram que este estudo foi financiado pela Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC) (TO 2023TR501) e pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Código de Financiamento 001).
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Resumo

Objetivo Analisar o trofismo muscular e a de interleucina-6 no músculo bíceps braquial de ratas com lesão medular cervical incompleta tratados com estimulação elétrica neuromuscular (EENM).

Métodos Ratas adultas foram submetidas à hemissecção da medula espinal em C5-C7 e a um protocolo de EENM de 5 semanas. O trofismo do bíceps braquial foi avaliado pela relação peso muscular/peso corporal e análise histológica. A expressão de interleucina-6 no bíceps braquial foi medida usando ensaio de imunoabsorção enzimática.

Resultados O grupo tratado com EENM apresentou preservação do trofismo muscular, assim como prevenção da redução dos níveis de interleucina-6.

Conclusão A lesão da medula espinal causa atrofia muscular e diminui a expressão de interleucina-6. Essas alterações são parcialmente prevenidas pela EENM. Os resultados sugerem um possível mecanismo de ação da EENM e ressaltam o uso clínico desta ferramenta terapêutica.

Palavras-chave

atrofia muscular - interleucina-6 - paralisia - reabilitação - terapia por estimulação elétrica - traumatismos da medula espinal

Trabalho desenvolvido na Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brasil.




Publication History

Received: 23 August 2023

Accepted: 20 February 2024

Article published online:
04 September 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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