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CC BY 4.0 · Eur J Dent 2024; 18(04): 971-975
DOI: 10.1055/s-0044-1787820
Review Article

The Influence of Genetics and Gene Polymorphism on Biological Complications for Dental Implant Survival: A Review

Marcella Santos Januzzi 
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
Daniela Micheline dos Santos
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
Cleber Davi Del Rei Daltro Rosa
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
Karina Helga Leal Turcio
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
Clóvis Lamartine de Moraes Melo Neto 
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
Maria Eduarda da Silva Fernandes
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
André Pinheiro de Magalhães Bertoz 
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
Manuel Martin Adriazola Ique 
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
,
Marcelo Coelho Goiato 
1   Department of Dental Materials and Prosthetics, School of Dentistry, São Paulo State University, Araçatuba, Brazil
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Abstract

The objective of this review is to expose the main genetic changes and genetic polymorphisms that may or may not be associated with greater susceptibility to reduced survival of dental implants and, consequently, to their loss. Case–control studies that fully portrayed the specific types of genetic polymorphisms that may be associated with dental implant failure were included by searching in the PubMed, Scopus, and Web of Science databases from 2010 to 2023. The following descriptors and their combinations in English were used to search for articles: “dental implants,” “bone genes,” “genetics,” “polymorphism genetics,” “genetic risk factor,” and “interleukin.” The initial search resulted in 107 results (PubMed n = 47, Scopus n = 14, and Web of Science n = 46). After a manual search, reviewing each article's title and abstract, and excluding duplicates, systematic reviews, and literature reviews, 30 articles were selected. After reading these 30 articles in full, 18 studies that did not describe the specific genetic polymorphism in relation to dental implant survival were excluded. Therefore, 12 articles were included in this review. The genetic polymorphisms of interleukin (IL)-1A, IL-1B, IL-4, IL-6, IL-10, IL-1 receptor antagonist, tumor necrosis factor-α, receptor activator of nuclear factor kappa B legend, and cluster of differentiation 14 were analyzed in the included studies. In seven of the studies, a statistically significant correlation between genetic polymorphisms and dental implant failure was observed. Of the polymorphisms studied, IL-1A (−899), IL-1B (+3954), and IL-4 (+33) showed a greater association with dental implant loss.

Keywords

dental implants - genetics - genetic polymorphism - genetic risk factor - interleukins


Publication History

Article published online:
16 July 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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