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Clin Colon Rectal Surg
DOI: 10.1055/s-0044-1787883
Review Article

The Young: Early-Onset Colon Cancer

David Cohen
1   Department of Surgery, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York
,
Caitlin Rogers
2   Herbert Irving Comprehensive Cancer Research Center, Columbia University, New York, New York
,
Joel Gabre
2   Herbert Irving Comprehensive Cancer Research Center, Columbia University, New York, New York
3   Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York
,
Beatrice Dionigi
4   Division of Colon and Rectal Surgery, New York-Presbyterian/Columbia University Medical Center, New York, New York
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Abstract

Early-onset colorectal cancer (EO-CRC), characterized by diagnosis before the age of 50 years, has emerged as a significant healthcare challenge with increasing global incidence. While traditional risk factors such as family history and inherited syndromes contribute to EO-CRC, a substantial proportion of cases remain sporadic, necessitating further investigation into additional etiological factors. Molecular studies reveal heterogeneity in EO-CRC, with distinct mutational profiles compared to late-onset CRC. Clinical management presents unique considerations, including challenges in early detection and treatment strategies tailored to younger patients. Addressing EO-CRC requires a multidisciplinary approach integrating epidemiological, molecular, and clinical insights to improve prevention, diagnosis, and therapeutic outcomes. Emerging research avenues explore novel biomarkers and therapeutic targets, offering promise for advancing understanding and management of this disease in contemporary oncology practice.

Keywords

colon cancer - rectal cancer - early-onset cancer


Publication History

Article published online:
02 July 2024

© 2024. Thieme. All rights reserved.

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