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CC BY 4.0 · Avicenna J Med 2024; 14(03): 137-145
DOI: 10.1055/s-0044-1788040
Review Article

Clearing the Skepticism about Subclinical Hypothyroidism: Is It Beneficial to Treat Patients with Thyroid-Stimulating Hormone >4.5 and <10 mIU/L?

Hafsa Bushra 
1   Department of Internal Medicine, Royal Commission Hospital Jubail, Jubail, Saudi Arabia
,
Murtaza Rashid 
2   Department of Emergency Medicine, Royal Commission Hospital Jubail, Jubail, Saudi Arabia
› Author Affiliations Funding None.
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Abstract

Subclinical hypothyroidism (SCH) is a heterogeneous clinical condition ranging from asymptomatic to wide variety of clinical manifestations, which are often nonspecific. Being a common laboratory finding, clinicians often face the dilemma of whether to treat or not. Threshold of 10 mIU/L of thyroid-stimulating hormone (TSH) is often used as a cutoff limit to offer treatment. However, still, debate remains on whether to treat less than 10 mIU/L considering special clinical conditions like pregnancy. Whether SCH exists, is screening needed in asymptomatic individuals, is treating asymptomatic cases beneficial or harmful and what threshold level of TSH to be considered for treatment are all potential questions that need to be answered.

Keywords

hypothyroidism - subclinical hypothyroidism - thyroid - thyroxine


Publication History

Article published online:
03 July 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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