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CC BY 4.0 · Journal of Clinical Interventional Radiology ISVIR
DOI: 10.1055/s-0044-1788253
Original Article

Clinical and Radiologic Outcomes after Cryoablation of Desmoid Tumors

Brad Bergin 
1   Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
,
Lucas Killian Newman
1   Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
,
Stefan Przybojewski
1   Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
› Author Affiliations Funding None.
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Abstract

Purpose This study aims to evaluate the impact of cryoablation on patients with desmoid tumors, considering both pain and functional impairment. Cryoablation has emerged as a promising intervention, primarily recognized for its ability to reduce radiological evidence of the neoplasm. However, the focus of this research is on assessing the clinical outcomes, recognizing the importance of improving patient-reported symptoms as additional evidence is required in this area to strengthen previous findings.

Methods A retrospective study of 18 patients treated with cryoablation for desmoid tumors were included in this study. The evaluation of clinical status involved structured interviews to capture changes in pain and functional impairment. Pain scores and functional impairment scores were recorded on a 10-point Likert scale before and after the treatment. The correlation between these clinical findings and imaging was a key aspect of the investigation.

Results Following cryoablation treatment, the average pain scores exhibited a notable decrease of 4.75 points on the 10-point Likert scale. Similarly, functional impairment scores demonstrated a significant average decrease of 4.0 points. Additionally, there was an overall decrease in viable tumor volume after ablation, correlating with the above findings.

Conclusion This study provides evidence that cryoablation is effective in achieving clinically significant improvement in patients with desmoid tumors. While the reduction in radiological evidence is recognized, the emphasis of this study was on patient-reported outcomes, particularly in pain and functional impairment. These findings underscore that cryoablation is a valuable intervention in the comprehensive management of desmoid tumors improving overall quality of life.

Keywords

desmoid tumors - cryoablation

Ethical approval

Approval by Conjoint Health Research Ethics Board at the University of Calgary. Ethics ID: REB21–1623.




Publication History

Article published online:
22 July 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Master SR, Mangla A, Puckett Y, Shah C. Desmoid Tumor. StatPearls. Florida, USA: StatPearls Publishing; 2022
    Google Scholar
  • 2 Quintini C, Ward G, Shatnawei A. et al. Mortality of intra-abdominal desmoid tumors in patients with familial adenomatous polyposis: a single center review of 154 patients. Ann Surg 2012; 255 (03) 511-516
    CrossrefPubMedGoogle Scholar
  • 3 Nieuwenhuis MH, Casparie M, Mathus-Vliegen LM, Dekkers OM, Hogendoorn PC, Vasen HF. A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. Int J Cancer 2011; 129 (01) 256-261
    CrossrefPubMedGoogle Scholar
  • 4 Auloge P, Garnon J, Robinson JM. et al. Percutaneous cryoablation for advanced and refractory extra-abdominal desmoid tumors. Int J Clin Oncol 2021; 26 (06) 1147-1158
    CrossrefPubMedGoogle Scholar
  • 5 Bouhamama A, Lame F, Mastier C. et al. Local control and analgesic efficacy of percutaneous cryoablation for desmoid tumors. Cardiovasc Intervent Radiol 2020; 43 (01) 110-119
    CrossrefPubMedGoogle Scholar
  • 6 Kurtz JE, Buy X, Deschamps F. et al. CRYODESMO-O1: a prospective, open phase II study of cryoablation in desmoid tumour patients progressing after medical treatment. Eur J Cancer 2021; 143: 78-87
    CrossrefPubMedGoogle Scholar
  • 7 Liu S, Miramontes B, Souza FF. et al. Cryoablation as an effective treatment for desmoid tumors: a single-institution case series. J Clin Oncol 2022; •••: 40
    PubMedGoogle Scholar
  • 8 Kasper B, Ströbel P, Hohenberger P. Desmoid tumors: clinical features and treatment options for advanced disease. Oncologist 2011; 16 (05) 682-693
    CrossrefPubMedGoogle Scholar
  • 9 Garbay D, Le Cesne A, Penel N. et al. Chemotherapy in patients with desmoid tumors: a study from the French Sarcoma Group (FSG). Ann Oncol 2012; 23 (01) 182-186
    CrossrefPubMedGoogle Scholar
  • 10 Tsukamoto S, Takahama T, Mavrogenis AF, Tanaka Y, Tanaka Y, Errani C. Clinical outcomes of medical treatments for progressive desmoid tumors following active surveillance: a systematic review. Musculoskelet Surg 2022
    PubMedGoogle Scholar
  • 11 Cho JY, Gupta S, Cho HS. et al. Role of nonsteroidal anti-inflammatory drug in treatment of extra-abdominal desmoid tumors. Clin Orthop Surg 2018; 10 (02) 225-233
    CrossrefPubMedGoogle Scholar
  • 12 Yan YY, Walsh JP, Munk PL. et al. A single-center 10-year retrospective analysis of cryoablation for the management of desmoid tumors. J Vasc Interv Radiol 2021; 32 (09) 1277-1287
    CrossrefPubMedGoogle Scholar
  • 13 Baerlocher MO, Nikolic B, Sze DY. Adverse event classification: clarification and validation of the Society of Interventional Radiology Specialty-Specific System. J Vasc Interv Radiol 2023; 34 (01) 1-3
    CrossrefPubMedGoogle Scholar