PDF herunterladen
CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2025; 35(01): 148-158
DOI: 10.1055/s-0044-1788590
Review Article

Multimodality Imaging in the Diagnosis and Staging of Gestational Choriocarcinoma

Anitha Mandava 
1   Department of Radiodiagnosis, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
,
Veeraiah Koppula 
1   Department of Radiodiagnosis, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
,
Meghana Kandati 
1   Department of Radiodiagnosis, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
,
Arvind K. Reddy 
1   Department of Radiodiagnosis, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
,
Senthil J. Rajappa 
2   Department of Medical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
,
T. S. Rao 
3   Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana, India
› Institutsangaben Funding None.
› Weitere Informationen
Auch verfügbar auf
   Lizenzen und Reprints

Abstract

Choriocarcinoma is an uncommon, highly invasive malignancy arising from the placental trophoblastic tissue. Though staging is clinical, imaging has significant role in the diagnosis, staging, prognostic risk scoring, and management of choriocarcinomas. The purpose of this article is to review the role of multimodality imaging in the diagnosis, staging, and management of choriocarcinomas in correlation with clinicopathologic findings.

Keywords

choriocarcinoma - ultrasound - color Doppler - computed tomography - positron emission tomography - magnetic resonance imaging

Ethical Approval

The study was approved by the Institutional Ethics Committee, Basavatarakam Indo American Cancer Hospital & Research Institute (Reference No: IEC/2022/160).


Authors' Contributions

A.M. and V.K. researched the literature and conceived the study. A.M. wrote the first draft of the manuscript. All the authors reviewed and edited the manuscript and approved the final version of the manuscript.




Publikationsverlauf

Artikel online veröffentlicht:
09. August 2024

© 2024. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Amin MB, Edge S, Greene F. et al., eds. AJCC Cancer Staging Manual. 8th ed.. Cham: Springer International Publishing; 2017: 257-260
    Suche in Google Scholar
  • 2 Ngan HY, Bender H, Benedet JL. et al. FIGO Committee on Gynecologic Oncology. Gestational trophoblastic neoplasia, FIGO 2000 staging and classification. Int J Gynaecol Obstet 2003; 83: 75-77
    PubMedSuche in Google Scholar
  • 3 Dudiak KM, Maturen KE, Akin EA. et al; Expert Panel on Women's Imaging Panel. ACR appropriateness criteria® Gestational trophoblastic disease. J Am Coll Radiol 2019; 16 (11S): S348-S363
    CrossrefPubMedSuche in Google Scholar
  • 4 Ober WB, Fass RO. The early history of choriocarcinoma. J Hist Med Allied Sci 1961; 16: 49-73
    CrossrefPubMedSuche in Google Scholar
  • 5 Soper JT. Gestational trophoblastic disease. Obstet Gynecol 2006; 108 (01) 176-187
    CrossrefPubMedSuche in Google Scholar
  • 6 Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol 2010; 203 (06) 531-539
    CrossrefPubMedSuche in Google Scholar
  • 7 Dhanda S, Ramani S, Thakur M. Gestational trophoblastic disease: a multimodality imaging approach with impact on diagnosis and management. Radiol Res Pract 2014; 2014: 842751
    CrossrefPubMedSuche in Google Scholar
  • 8 Ng TY, Wong LC. Diagnosis and management of gestational trophoblastic neoplasia. Best Pract Res Clin Obstet Gynaecol 2003; 17 (06) 893-903
    CrossrefPubMedSuche in Google Scholar
  • 9 Jain KA. Gestational trophoblastic disease: pictorial review. Ultrasound Q 2005; 21 (04) 245-253
    CrossrefPubMedSuche in Google Scholar
  • 10 Allen SD, Lim AK, Seckl MJ, Blunt DM, Mitchell AW. Radiology of gestational trophoblastic neoplasia. Clin Radiol 2006; 61 (04) 301-313
    CrossrefPubMedSuche in Google Scholar
  • 11 Bagley RG, Ren Y, Kurtzberg L. et al. Human choriocarcinomas: placental growth factor-dependent preclinical tumor models. Int J Oncol 2012; 40 (02) 479-486
    PubMedSuche in Google Scholar
  • 12 Kalhor N, Ramirez PT, Deavers MT, Malpica A, Silva EG. Immunohistochemical studies of trophoblastic tumors. Am J Surg Pathol 2009; 33 (04) 633-638
    CrossrefPubMedSuche in Google Scholar
  • 13 Kani KK, Lee JH, Dighe M, Moshiri M, Kolokythas O, Dubinsky T. Gestatational trophoblastic disease: multimodality imaging assessment with special emphasis on spectrum of abnormalities and value of imaging in staging and management of disease. Curr Probl Diagn Radiol 2012; 41 (01) 1-10
    CrossrefPubMedSuche in Google Scholar
  • 14 Lin LH, Bernardes LS, Hase EA, Fushida K, Francisco RP. Is Doppler ultrasound useful for evaluating gestational trophoblastic disease?. Clinics (São Paulo) 2015; 70 (12) 810-815
    CrossrefPubMedSuche in Google Scholar
  • 15 Agarwal R, Strickland S, McNeish IA. et al. Doppler ultrasonography of the uterine artery and the response to chemotherapy in patients with gestational trophoblastic tumors. Clin Cancer Res 2002; 8 (05) 1142-1147
    PubMedSuche in Google Scholar
  • 16 Sita-Lumsden A, Medani H, Fisher R. et al. Uterine artery pulsatility index improves prediction of methotrexate resistance in women with gestational trophoblastic neoplasia with FIGO score 5-6. BJOG 2013; 120 (08) 1012-1015
    CrossrefPubMedSuche in Google Scholar
  • 17 Qin J, Zhang S, Poon L. et al. Doppler-based predictive model for methotrexate resistance in low-risk gestational trophoblastic neoplasia with myometrial invasion: prospective study of 147 patients. Ultrasound Obstet Gynecol 2021; 57 (05) 829-839
    CrossrefPubMedSuche in Google Scholar
  • 18 Su N, Zhao C, Zhang B. et al. The role of contrast-enhanced ultrasound in evaluating gestational trophoblastic neoplasia: a preliminary study. Cancer Manag Res 2020; 12: 12163-12174
    CrossrefPubMedSuche in Google Scholar
  • 19 Mangili G, Bergamini A, Giorgione V. et al. [18F]fluorodeoxyglucose positron emission tomography/computed tomography and trophoblastic disease: the gynecologist perspective. Q J Nucl Med Mol Imaging 2016; 60 (02) 103-116
    PubMedSuche in Google Scholar
  • 20 Mapelli P, Mangili G, Picchio M. et al. Role of 18F-FDG PET in the management of gestational trophoblastic neoplasia. Eur J Nucl Med Mol Imaging 2013; 40 (04) 505-513
    CrossrefPubMedSuche in Google Scholar
  • 21 Wagner BJ, Woodward PJ, Dickey GE. From the archives of the AFIP. Gestational trophoblastic disease: radiologic-pathologic correlation. Radiographics 1996; 16 (01) 131-148
    CrossrefPubMedSuche in Google Scholar
  • 22 Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C. ESMO Guidelines Working Group. Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013; 24 (Suppl. 06) vi39-vi50
    CrossrefPubMedSuche in Google Scholar
  • 23 Price JM, Lo C, Abdi S. et al. The role of computed tomography scanning of the thorax in the initial assessment of gestational trophoblastic neoplasia. Int J Gynecol Cancer 2015; 25 (09) 1731-1736
    CrossrefPubMedSuche in Google Scholar
  • 24 Mangili G, Lorusso D, Brown J. et al. Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer InterGroup. Int J Gynecol Cancer 2014; 24 (9, suppl 3): S109-S116
    CrossrefPubMedSuche in Google Scholar
  • 25 Piura E, Piura B. Brain metastases from gestational trophoblastic neoplasia: review of pertinent literature. Eur J Gynaecol Oncol 2014; 35 (04) 359-367
    PubMedSuche in Google Scholar
  • 26 McCarthy CM, Unterscheider J, Burke C, Coulter J. Metastatic gestational choriocarcinoma: a masquerader in obstetrics. Ir J Med Sci 2018; 187 (01) 127-129
    CrossrefPubMedSuche in Google Scholar
  • 27 Polat P, Suma S, Kantarcý M, Alper F, Levent A. Color Doppler US in the evaluation of uterine vascular abnormalities. Radiographics 2002; 22 (01) 47-53
    CrossrefPubMedSuche in Google Scholar
  • 28 Touhami O, Gregoire J, Noel P, Trinh XB, Plante M. Uterine arteriovenous malformations following gestational trophoblastic neoplasia: a systematic review. Eur J Obstet Gynecol Reprod Biol 2014; 181: 54-59
    CrossrefPubMedSuche in Google Scholar
  • 29 Hanna RK, Soper JT. The role of surgery and radiation therapy in the management of gestational trophoblastic disease. The Oncologist 2010; 15 (06) 593-600
    CrossrefPubMedSuche in Google Scholar
  • 30 Goldstein DP, Berkowitz RS. Current management of gestational trophoblastic neoplasia. Hematol Oncol Clin North Am 2012; 26: 111-31
    CrossrefPubMedSuche in Google Scholar
  • 31 Brown J, Naumann RW, Seckl MJ, Schink J. 15 years of progress in gestational trophoblastic disease: scoring, standardization, and salvage. Gynecologic oncology 2017; 144: 200-207
    CrossrefPubMedSuche in Google Scholar
  • 32 Doll KM, Soper JT. The role of surgery in the management of gestational trophoblastic neoplasia. Obstet Gynecol Surv 2013; 68: 533-542
    CrossrefPubMedSuche in Google Scholar
  • 33 Soper JT. Staging and evaluation of gestational trophoblastic disease. Clin Obstet Gynecol 2003; 46 (03) 570-578
    CrossrefPubMedSuche in Google Scholar