Download PDF
CC BY 4.0 · Journal of Coloproctology 2024; 44(04): e281-e284
DOI: 10.1055/s-0044-1788665
Case Report

Granular Cell Tumor of the Anal Canal: Case Report and Literature Review

Jorge Arche Prats 
1   Department of General Surgery, Digestive Surgery, School of Medicine, Andrés Bello University, Providencia, Región Metropolitana, Chile
,
Diego García Prado 
2   Department of General Surgery, Digestive Surgery, University of Chile, Santiago, Región Metropolitana, Chile
,
Gonzalo Campaña Villegas 
3   Department of Clinical Coloproctology, INDISA Clinic, Faculty of Medicine, Andrés Bello University, Providencia, Región Metropolitana, Chile
,
Mónica Martínez Mardónez 
4   Department of Coloproctology, INDISA Clinic, Faculty of Medicine, University Finis Terrae, Providencia, Región Metropolitana, Chile
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Granular cell tumors (GCTs) are rare benign neoplasms that can occur anywhere in the body but are most commonly found in the head and neck region. These tumors are often asymptomatic and are incidentally discovered during routine rectal examination. In some cases, symptoms may include bleeding, pain, and a palpable mass. Imaging studies such as colonoscopy, ultrasound, magnetic resonance imaging (MRI), or computed tomography can be used to characterize and measure the tumor. Treatment typically involves local resection, with or without adjuvant radiotherapy, depending on the size, location, and pathological characteristics of the tumor. The prognosis for GCTs of the anal canal is generally good, with few cases of recurrence or metastasis reported, but long-term follow-up is recommended due to the potential for late recurrence or malignant transformation. The present study reports a 39-year-old female patient who presented with anal itching associated with protrusion of a perianal mass and who underwent treatment between November 2022 and December 2023. The MRI scan revealed a nodular image in its caudal aspect with involvement of the internal sphincter between 12 and 5 o'clock, which was successfully resected. Histopathology was compatible with GCT, and the patient had a satisfactory recovery and was discharged. In conclusion, GCTs of the anal canal are rare and extremely unusual tumors that can be difficult to diagnose and manage, requiring a multidisciplinary approach for optimal management.

Keywords

granular cell tumor - anal canal - neoplasm - diagnosis - prognosis

Authors' Contributions

J.A.P.: methodology, software, formal analysis, research, data curation, writing – review and editing, visualization, project management. D.G.P.: data curation, visualization. M.M.M.: conceptualization, validation, supervision, research, resources, writing – review and editing. G.C.V.: supervision, research, resources, writing – review and editing.




Publication History

Received: 19 September 2023

Accepted: 05 June 2024

Article published online:
01 August 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 

  • References

  • 1 Kim SJ, Kim TU, Choi CW, Kim HW, Park SB, Ryu DG. Underwater endoscopic mucosal resection of upper gastrointestinal subepithelial tumors: A case series pilot study (with video). Medicine (Baltimore) 2022; 101 (41) e31072
    CrossrefPubMedSearch in Google Scholar
  • 2 Fujii T, Morita H, Yamaguchi S, Tsutsumi S, Asao T, Kuwano H. A rare case of granular cell tumor of the anal region: diagnostic difficulty to masses in the anal area. Int Surg 2014; 99 (01) 45-47
    CrossrefPubMedSearch in Google Scholar
  • 3 Mistrangelo M, Cassoni P, Scozzari G. et al. Perianal granular cell tumor: report of a case and review of the literature. Tumori 2009; 95 (04) 538-541
    CrossrefPubMedSearch in Google Scholar
  • 4 Pagano N, Impellizzeri G, Di Simone MP. et al. Granular Data: A Rare Submucosal Tumor of the Colon-Case Report and Review of the Literature. Dig Dis Sci 2021; 66 (03) 714-722
    CrossrefPubMedSearch in Google Scholar
  • 5 Ma J, Cheng Y, Li X, Liu W, Liu R, Liu C. Rare case of granular cell tumor of perianal region: a case report and literature review. J Int Med Res 2021; 49 (01) 30 0060520982689
    CrossrefPubMedSearch in Google Scholar
  • 6 Cohen MG, Greenwald ML, Garbus JE, Zager JS. Granular cell tumor–a unique neoplasm of the internal anal sphincter: report of a case. Dis Colon Rectum 2000; 43 (10) 1444-1446 , discussion 1447
    CrossrefPubMedSearch in Google Scholar
  • 7 Sunderland MS, Dakwar A, Rasheid S. Rectal Granular Cell Carcinoma Requiring Abdominoperineal Resection. Am Surg 2023; 89 (04) 1304-1306
    CrossrefPubMedSearch in Google Scholar
  • 8 Marchand Crety C, Garbar C, Madelis G. et al. Adjuvant radiation therapy for malignant Abrikossoff's tumor: a case report about a femoral triangle localisation. Radiat Oncol 2018; 13 (01) 115
    CrossrefPubMedSearch in Google Scholar
  • 9 Francesco VD, Avellini C, Pappalardo S, Proscia D, Piccirillo F. Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: a casual association?. Indian J Dermatol 2010; 55 (04) 403-405
    CrossrefPubMedSearch in Google Scholar
  • 10 Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22 (07) 779-794 Erratum in: Am J Surg Pathol 1999 Jan;23(1):136. PMID: 9669341
    CrossrefPubMedSearch in Google Scholar
  • 11 Johnston J, Helwig EB. Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci 1981; 26 (09) 807-816
    CrossrefPubMedSearch in Google Scholar
  • 12 Cha JM, Lee JI, Joo KR. et al. Granular cell tumor of the descending colon treated by endoscopic mucosal resection: a case report and review of the literature. J Korean Med Sci 2009; 24 (02) 337-341
    CrossrefPubMedSearch in Google Scholar
  • 13 Yang SY, Min BS, Kim WR. A Granular Cell Tumor of the Rectum: A Case Report and Review of the Literature. Ann Coloproctol 2017; 33 (06) 245-248
    CrossrefPubMedSearch in Google Scholar
  • 14 Im S, Yoo C, Jung JH, Choi HJ, Yoo J, Kang CS. Primary perivascular epithelioid cell tumor in the rectum: a case report and review of the literature. Pathol Res Pract 2013; 209 (04) 244-248
    CrossrefPubMedSearch in Google Scholar
  • 15 Znati K, Harmouch T, Benlemlih A, Elfatemi H, Chbani L, Amarti A. Solitary granular cell tumor of cecum: a case report. ISRN Gastroenterol 2011; 2011: 943804
    CrossrefPubMedSearch in Google Scholar
  • 16 Mobarki M, Dumollard JM, Dal Col P, Camy F, Peoc'h M, Karpathiou G. Granular cell tumor a study of 42 cases and systemic review of the literature. Pathol Res Pract 2020; 216 (04) 152865
    CrossrefPubMedSearch in Google Scholar