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CC BY 4.0 · Avicenna J Med 2024; 14(03): 175-178
DOI: 10.1055/s-0044-1788687
Case Report

Dengue-Related Hemophagocytic Lymphohistiocytosis in an Adult: A Case Report and Brief Update

Anju Dinkar 
1   Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2   Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Jitendra Singh 
3   Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Nilesh Kumar
3   Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Kailash Kumar
3   Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Santosh Kumar Singh
3   Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
› Author Affiliations
Funding This study was financially supported by Seed Grant to new faculties under IoE for the year 2021-22-reg. (No. R/Dev/D/IoE/Seed Grant-II/2021-22/39980, dated January 2022).
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Abstract

Dengue virus is an arbovirus transmitted through the bite of infected Aedes mosquitoes. Many unusual clinical features are being reported in dengue. Dengue complicated with hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal condition. Here, we report an 18-year-old otherwise healthy female with dengue fever complicated with HLH. The diagnosis was made by fulfilling the clinical and laboratory criteria of HLH. She was managed successfully with a methylprednisolone pulse regimen. Our case highlights the importance of early recognition of complications and prompt treatment for a better outcome.

Keywords

viral infection - corticosteroids - multiorgan failure - hyperinflammatory state - macrophage activation syndrome

Ethics Approval and Consent to Participate

Since the manuscript was a case report, as per our institutional ethical committee, ethical approval is not required. Written and informed consent was obtained from the patient to participate in the study.


Presentation at a Meeting

None.


Consent for Publication

Written and informed consent was taken from the patient for the publication of the case study.


Authors' Contributions

A.D.: Conceptualization, investigation, supervision, writing, and editing of the original draft. J.S.: conceptualization, validation, formal analysis, investigation, supervision, writing, and editing of the original draft. N.K.: formal analysis, data collection, reviewing, and editing. K.K.: data collection, reviewing, and editing. S.K.S.: formal analysis, reviewing, and editing.




Publication History

Article published online:
25 September 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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