RSS-Feed abonnieren
DOI: 10.1055/s-0044-1788738
Trifecta of Tumors: Simultaneous Detection of Three Primary Malignancies by Different Radiotracers of Nuclear Medicine
Abstract
Malignancies are increasing worldwide with changing lifestyle, pollution, increasing life expectancy, and diagnostic advancements. However, multiple primary malignancies (MPMs) detected simultaneously are very rare. Here, we present a rare case of three primary malignancies (sigmoid colon, prostate, and thyroid) detected simultaneously in a 77-year-old male patient, who initially presented with bleeding per rectum and was then found to have a large pedunculated mass in the sigmoid colon on colonoscopy, which further turned out to be adenocarcinoma. On further imaging and investigations, two new separate malignancies (prostate and thyroid) were found by two different positron emission tomography radiotracers: prostate-specific membrane antigen (PSMA) and fluorodeoxyglucose (FDG). Hence, nuclear medicine modalities can play an important role in detecting MPMs using the vast array of radiotracers available now and perhaps reduce the need for multiple biopsies.
Publikationsverlauf
Artikel online veröffentlicht:
24. Juli 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Almasan I, Piciu D. Triple primary malignancies: tumor associations, survival, and clinicopathological analysis: a 25-year single-institution experience. Healthcare (Basel) 2023; 11 (05) 738
- 2 Haffner MC, Kronberger IE, Ross JS. et al. Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. Hum Pathol 2009; 40 (12) 1754-1761
- 3 Coyte A, Morrison DS, McLoone P. Second primary cancer risk: the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study. BMC Cancer 2014; 14: 272
- 4 Moertel CG. Multiple primary malignant neoplasms: historical perspectives. Cancer 1977; 40 (04) 1786-1792
- 5 Vogt A, Schmid S, Heinimann K. et al. Multiple primary tumours: challenges and approaches, a review. ESMO Open 2017; 2 (02) e000172
- 6 Ishimori T, Patel PV, Wahl RL. Detection of unexpected additional primary malignancies with PET/CT. J Nucl Med 2005; 46 (05) 752-757
- 7 Al-Ibraheem A, Hammoudeh R, Kasasbeh N, Abdlkadir AS, Juweid ME. Synchronous colorectal and prostate cancer: dual PET/CT approach for detecting and distinguishing metastatic patterns. Nucl Med Mol Imaging 2023; 57 (06) 291-294
- 8 Ciappuccini R, Saguet-Rysanek V, Giffard F. et al. PSMA expression in differentiated thyroid cancer: association with radioiodine, 18FDG uptake, and patient outcome. J Clin Endocrinol Metab 2021; 106 (12) 3536-3545
- 9 Bychkov A, Vutrapongwatana U, Tepmongkol S, Keelawat S. PSMA expression by microvasculature of thyroid tumors: potential implications for PSMA theranostics. Sci Rep 2017; 7 (01) 5202