Shifting Priorities in the Prevention of Venous Thromboembolism: Time to Focus on Overall Cardiovascular Health

Stavros V. Konstantinides

doi:10.1055/s-0044-1788926

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2024; 124(10): 958-961
DOI: 10.1055/s-0044-1788926

Invited Editorial Focus

Shifting Priorities in the Prevention of Venous Thromboembolism: Time to Focus on Overall Cardiovascular Health

Stavros V. Konstantinides

¹Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

²Department of Cardiology, Democritus University of Thrace, Alexandroupolis, Greece

› Author Affiliations

Abstract

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References

References
1 Liang B, Zha L, Peng B. et al. Association of cardiovascular health with the incidence of venous thromboembolism: a prospective study of 275,149 participants from the UK Biobank. Thromb Haemost 2024; (e-pub ahead of print)
2 Lloyd-Jones DM, Allen NB, Anderson CAM. et al; American Heart Association. Life's Essential 8: updating and enhancing the American Heart Association's construct of cardiovascular health: a presidential advisory from the American Heart Association. Circulation 2022; 146 (05) e18-e43
3 Bikdeli B, Wang Y, Jimenez D. et al. Pulmonary embolism hospitalization, readmission, and mortality rates in US older adults, 1999-2015. JAMA 2019; 322 (06) 574-576
4 Keller K, Hobohm L, Ebner M. et al. Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany. Eur Heart J 2020; 41 (04) 522-529
5 Barco S, Mahmoudpour SH, Valerio L. et al. Trends in mortality related to pulmonary embolism in the European Region, 2000-15: analysis of vital registration data from the WHO Mortality Database. Lancet Respir Med 2020; 8 (03) 277-287
6 Barco S, Valerio L, Ageno W. et al. Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000-18: an analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database. Lancet Respir Med 2021; 9 (01) 33-42
7 Mohr K, Hobohm L, Kaier K. et al. Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism. Clin Res Cardiol 2024; (e-pub ahead of print)
8 Mazzolai L, Ageno W, Alatri A. et al. Second consensus document on diagnosis and management of acute deep vein thrombosis: updated document elaborated by the ESC Working Group on aorta and peripheral vascular diseases and the ESC Working Group on pulmonary circulation and right ventricular function. Eur J Prev Cardiol 2022; 29 (08) 1248-1263
9 Konstantinides SV, Meyer G, Becattini C. et al; ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2020; 41 (04) 543-603
10 Stevens SM, Woller SC, Kreuziger LB. et al. Antithrombotic therapy for VTE disease: second update of the CHEST guideline and expert panel report. Chest 2021; 160 (06) e545-e608
11 Lyman GH, Carrier M, Ay C. et al. American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv 2021; 5 (04) 927-974
12 Cuker A, Tseng EK, Nieuwlaat R. et al. American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv 2021; 5 (03) 872-888
13 Ortel TL, Neumann I, Ageno W. et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. Blood Adv 2020; 4 (19) 4693-4738
14 Anderson DR, Morgano GP, Bennett C. et al. American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients. Blood Adv 2019; 3 (23) 3898-3944
15 Bates SM, Rajasekhar A, Middeldorp S. et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy. Blood Adv 2018; 2 (22) 3317-3359
16 Prins MH, Lensing AWA, Prandoni P. et al. Risk of recurrent venous thromboembolism according to baseline risk factor profiles. Blood Adv 2018; 2 (07) 788-796
17 Mai V, Guay CA, Perreault L. et al. Extended anticoagulation for VTE: a systematic review and meta-analysis. Chest 2019; 155 (06) 1199-1216
18 Mai V, Bertoletti L, Cucherat M. et al. Extended anticoagulation for the secondary prevention of venous thromboembolic events: an updated network meta-analysis. PLoS One 2019; 14 (04) e0214134
19 Agnelli G, Becattini C, Meyer G. et al; Caravaggio Investigators. Apixaban for the treatment of venous thromboembolism associated with cancer. N Engl J Med 2020; 382 (17) 1599-1607
20 Mahé I, Agnelli G, Ay C. et al. Extended anticoagulant treatment with full- or reduced-dose apixaban in patients with cancer-associated venous thromboembolism: rationale and design of the API-CAT study. Thromb Haemost 2022; 122 (04) 646-656
21 Schenker C, Stalder O, Méan M. et al. Bleeding risk in elderly patients with venous thromboembolism who would have been excluded from anticoagulation trials. Thromb Haemost 2023; 123 (04) 427-437
22 Mohr K, Mildenberger P, Neusius T. et al. Estimated annual healthcare costs after acute pulmonary embolism: results from a prospective multicentre cohort study. Eur Heart J Qual Care Clin Outcomes 2024; (e-pub ahead of print)
23 Klok FA, Ageno W, Ay C. et al. Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society. Eur Heart J 2022; 43 (03) 183-189
24 Ten Cate V, Prochaska JH, Schulz A. et al. Clinical profile and outcome of isolated pulmonary embolism: a systematic review and meta-analysis. EClinicalMedicine 2023; 59: 101973
25 Xiang H, Liu M, Zhou C. et al. Tea consumption, milk or sweeteners addition, genetic variation in caffeine metabolism, and incident venous thromboembolism. Thromb Haemost 2024; (e-pub ahead of print)
26 Huang Y, Zhang Y, Yang S. et al. Association and pathways between dietary manganese intake and incident venous thromboembolism. Thromb Haemost 2024; 124 (06) 546-554
27 Du HC. Deng BY. Obesity-related traits mediate the effects of educational attainment on the risk of varicose veins, venous thromboembolism, and phlebitis. Thromb Haemost 2024; (e-pub ahead of print)
28 Frischmuth T, Tøndel BG, Brækkan SK, Hansen JB, Morelli VM. The risk of incident venous thromboembolism attributed to overweight and obesity: the Tromsø study. Thromb Haemost 2024; 124 (03) 239-249
29 Xu K, Chan NC. Risk factors for venous thromboembolism in women of childbearing age. Thromb Haemost 2023; 123 (11) 1069-1071
30 Zhang YJ, Li ZH, Shen D. et al. Association of combined lifestyle and polygenetic risk with incidence of venous thromboembolism: a large population-based cohort study. Thromb Haemost 2022; 122 (09) 1549-1557
31 Stakos D, Skendros P, Konstantinides S, Ritis K. Traps N′ clots: NET-mediated thrombosis and related diseases. Thromb Haemost 2020; 120 (03) 373-383
32 Joseph P, Glynn R, Lonn E. et al. Rosuvastatin for the prevention of venous thromboembolism: a pooled analysis of the HOPE-3 and JUPITER randomized controlled trials. Cardiovasc Res 2022; 118 (03) 897-903
33 Farmakis IT, Christodoulou KC, Hobohm L, Konstantinides SV, Valerio L. Lipid lowering for prevention of venous thromboembolism: a network meta-analysis. Eur Heart J 2024; (e-pub ahead of print)
34 Jervan Ø, Haukeland-Parker S, Gleditsch J. et al. The effects of exercise training in patients with persistent dyspnea following pulmonary embolism: a randomized controlled trial. Chest 2023; 164 (04) 981-991
35 Boon GJAM, Janssen SMJ, Barco S. et al. Efficacy and safety of a 12-week outpatient pulmonary rehabilitation program in Post-PE syndrome. Thromb Res 2021; 206: 66-75
36 Holland AE, Cox NS, Houchen-Wolloff L. et al. Defining modern pulmonary rehabilitation. an official American Thoracic Society workshop report. Ann Am Thorac Soc 2021; 18 (05) e12-e29
37 Pelliccia A, Sharma S, Gati S. et al; ESC Scientific Document Group. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J 2021; 42 (01) 17-96
38 Rauch B, Salzwedel A, Bjarnason-Wehrens B. et al; On Behalf Of The Cardiac Rehabilitation Guideline Group. Cardiac rehabilitation in German speaking countries of europe-evidence-based guidelines from Germany, Austria and Switzerland LLKardReha-DACH-Part 1. J Clin Med 2021; 10 (10) 2192
39 Nopp S, Klok FA, Moik F. et al. Outpatient pulmonary rehabilitation in patients with persisting symptoms after pulmonary embolism. J Clin Med 2020; 9 (06) 1811