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CC BY 4.0 · Eur J Dent 2025; 19(01): 015-023
DOI: 10.1055/s-0044-1789016
Review Article

Anticancer Potential of Quercetin on Oral Squamous Cell Carcinoma: A Scoping Review and Molecular Docking

Dhona Afriza 
1   Department of Oral Biology, Faculty of Dentistry, Baiturrahmah University, Kota Padang, Sumatera Barat, Indonesia
,
Utmi Arma
2   Department of Oral Medicine, Faculty of Dentistry, Baiturrahmah University, Kota Padang, Sumatera Barat, Indonesia
,
Raefany Faslah
3   Department of Oral Medicine, Faculty of Dentistry, Baiturrahmah University, Kota Padang, Sumatera Barat, Indonesia
,
Wastuti Hidayati Suriyah
4   Department of Oral Biology, Faculty of Dentistry, University of YARSI, DKI, Jakarta, Indonesia
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Abstract

Oral squamous cell carcinoma (OSCC) is a type of cancer that has a low survival rate and high recurrence and metastasis rates. To date, there is still no effective treatment for OSCC. Various types of cancer, including OSCC, have reported quercetin to act as an anticancer agent, but there is no clear research data on how it may affect OSCC. To determine the anticancer potential of quercetin in OSCC, we conducted a scoping review, and to determine the interaction of quercetin with one of the proteins that plays a role in carcinogenesis, namely, BCL-2, we conducted molecular docking. The scoping review process was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. The scoping review was searched by collecting articles related to the research topic in Google Scholar, PubMed, ScienceDirect, Cochrane, and EBSCOhost databases. All of the literature records found during the search were imported into the Mendeley software to remove duplication. Nine studies were generated after the titles and abstracts were reviewed according to the inclusion and exclusion criteria. After the full-text screening, no studies were excluded, leaving nine publications determined to be eligible for inclusion in the scoping review. Quercetin showed effects on inhibiting cancer invasion, migration, proliferation, and many protein expressions, as well as increasing cell apoptosis. Molecular docking was done for quercetin and BCl-2 protein. Doxorubicin was utilized as a comparison ligand. The in silico study was utilized using AutoDock Vina, AutoDock Tools 1.5.6, Biovia Discovery Studio 2021, and PyMol. Molecular docking indicated quercetin has a strong binding affinity with BCl-2 protein (ΔG –7.2 kcal/mol). Both scoping review and molecular docking revealed that quercetin is a promising candidate for anticancer agent.

Keywords

quercetin - BCl-2 - oral cancer - scoping review - molecular docking

Supplementary Material



Publication History

Article published online:
30 September 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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