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CC BY 4.0 · Int Arch Otorhinolaryngol 2025; 29(01): s00441789255
DOI: 10.1055/s-0044-1789255
Original Research

Impact of Severity of Sickle Cell Anemia on Auditory Discrimination Ability and Speech Perception in Noise

Preeti Sahu 
1   Department of ENT & HNS, All India Institute of Medical Sciences, Raipur, Raipur, Chhattisgarh, India
,
Animesh Barman
2   Department of Audiology, All India Institute of Speech and Hearing, Mysore, Karnataka, India
› Author Affiliations Funding The authors declare that they did not receive financial support from agencies in the public, private, or non-profit sectors to conduct the present study.
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Abstract

Introduction Sickle cell anemia (SCA) is a genetic disorder with clinical manifestations due to circulatory changes, leading to adverse effects on the auditory system that might impact auditory processing, such as auditory discrimination and speech perception ability. This condition is associated with the severity level of anemia.

Objective The purpose of the present study was to investigate the influence of anemia severity on auditory discrimination ability and speech perception in noise among SCA patients with normal hearing sensitivity.

Methods A total of 52 normal-hearing adults diagnosed with SCA in the age range of 15 to 40 were grouped into mild, moderate, and severe, based on anemia severity. Auditory discrimination tests for frequency, intensity, and duration were evaluated at 500 and 4,000 Hz along with speech perception in noise (SPIN) at 0 dB SNR using the mlp toolbox in the MATLAB software, version 2014a (MathWorks, Natick, MA, USA). The IBM Statistical Package for Social Sciences (SPSS) version 26.0 (IBM Corp., Armonk, NY, USA) was used for statistical analysis.

Results The results revealed an increase in median and interquartile range among anemia groups with increasing severity. Additionally, the median scores were found to be poorer for the higher frequency in all auditory discrimination tests than for the lower one. A regression in performance with an increase in severity for the SPIN test was observed.

Conclusion The severity of anemia plays an important role in functional auditory processing deterioration. Circulatory changes secondary to SCA affected auditory discrimination processing and speech perception in noise. However, all auditory discrimination abilities are not necessarily affected equally.

Keywords

sickle cell anemia (SCA) - speech perception - auditory function

Author's Contribution

P.S.: Concept and design of the study, data collection, results interpretation, review of literature, and writing of the first draft of the manuscript and setting of references. A.B.: Concept and design of the study, review of literature, critical revisions, and approval of the final version.




Publication History

Received: 26 April 2024

Accepted: 30 June 2024

Article published online:
10 January 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Preeti Sahu, Animesh Barman. Impact of Severity of Sickle Cell Anemia on Auditory Discrimination Ability and Speech Perception in Noise. Int Arch Otorhinolaryngol 2025; 29: s00441789255.
DOI: 10.1055/s-0044-1789255
 

  • References

  • 1 Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad Sci 2019; 1450 (01) 15-31
    CrossrefPubMedSearch in Google Scholar
  • 2 Olatunya OS, Babatola AO, Adeniyi AT. et al. Determinants of Care-Seeking Practices for Children with Sickle Cell Disease in Ekiti, Southwest Nigeria. J Blood Med 2021; 12 (12) 123-132 https://scite.ai/reports/10.2147/jbm.s294952
    CrossrefPubMedSearch in Google Scholar
  • 3 Lionnet F, Hammoudi N, Stojanovic KS. et al. Hemoglobin sickle cell disease complications: a clinical study of 179 cases. Haematologica 2012; 97 (08) 1136-1141
    CrossrefPubMedSearch in Google Scholar
  • 4 Kiser ZM, Clark KA, Sumner JL, Vercellotti GM, Nelson MD. Association between Sensorineural Hearing Loss and Homozygous Sickle Cell Anemia: A Meta-Analysis. Blood 2019; 134 (01) 3453
    CrossrefSearch in Google Scholar
  • 5 Sharp M, Orchik DJ. Auditory function in sickle cell anemia. Arch Otolaryngol 1978; 104 (06) 322-324
    CrossrefPubMedSearch in Google Scholar
  • 6 Armstrong FD, Thompson Jr RJ, Wang W. et al; Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Cognitive functioning and brain magnetic resonance imaging in children with sickle Cell disease. Pediatrics 1996; 97 (6 Pt 1): 864-870
    CrossrefPubMedSearch in Google Scholar
  • 7 Pegelow CH, Macklin EA, Moser FG. et al. Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Blood 2002; 99 (08) 3014-3018
    CrossrefPubMedSearch in Google Scholar
  • 8 American Academy of Audiology. Diagnosis, treatment, and management of children and adults with central auditory processing disorder: Clinical practice guidelines 2010 [available at]. https://audiology-web.s3.amazonaws.com/migrated/CAPD%20Guidelines%208-2010.pdf_539952af956c79.73897613
  • 9 Murphy S, Dalton P, Spence C. Selective Attention in Vision, Audition, and Touch. Stein J. ed, Reference module in neuroscience and biobehavioral psychology. Elsevier: 2017;155–170.
    Crossref
  • 10 Cabrera D, Cabrera L, Powers E. A Unifying Theory of Systems Thinking with Psychosocial Applications. Systems Research and Behavioral Science. Syst Res 2015; 32 (05) 534-545
    CrossrefSearch in Google Scholar
  • 11 Lagacé J, Jutras B, Gagné JP. Auditory processing disorder and speech perception problems in noise: finding the underlying origin. Am J Audiol 2010; 19 (01) 17-25
    CrossrefPubMedSearch in Google Scholar
  • 12 Fitzgibbons PJ, Gordon-Salant S. Behavioral studies with aging humans. Hearing sensitivity and psychoacoustics. Gordon-Salant S, Popper AN, Frisina RD, Fay RR. eds. The aging auditory system Springer Publishing Group; 2009;111–134.
  • 13 WHO. Haemoglobin concentrations for the diagnosis of anemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, 2011 (WHO/NMH/NHD/MNM/11.1). (http://www.who.int/vmnis/indicators/haemoglobin. pdf, accessed [22/09/2023]
  • 14 Mohammed SH, Shab-Bidar S, Abuzerr S, Habtewold TD, Alizadeh S, Djafarian K. Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis. BMC Res Notes 2019; 12 (01) 283
    CrossrefPubMedSearch in Google Scholar
  • 15 Orlikoff RF, Schiavetti N, Metz DE. Evaluating research in communication disorders 7th edn. Boston, MA: Allyn & Bacon/Pearson; 2015: 135-143
    Search in Google Scholar
  • 16 Grassi M, Soranzo A. MLP: a MATLAB toolbox for rapid and reliable auditory threshold estimation. Behav Res Methods 2009; 41 (01) 20-28
    CrossrefPubMedSearch in Google Scholar
  • 17 Green DM. A maximum-likelihood method for estimating thresholds in a yes-no task. J Acoust Soc Am 1993; 93 (4 Pt 1): 2096-2105
    CrossrefPubMedSearch in Google Scholar
  • 18 Dubno JR, Lee FS, Matthews LJ, Mills JH. Age-related and gender-related changes in monaural speech recognition. J Speech Lang Hear Res 1997; 40 (02) 444-452
    CrossrefPubMedSearch in Google Scholar
  • 19 Abel SM. Duration discrimination of noise and tone bursts. J Acoust Soc Am 1972; 51 (04) 1219-1223
    CrossrefPubMedSearch in Google Scholar
  • 20 Sangamanatha AV, Fernandes J, Bhat J, Srivastava M, Prakrithi SU. Temporal resolution in individuals with and without musical training. J Ind Speech Hear Assoc 2012; 26 (01) 27-35
    Search in Google Scholar
  • 21 Jain C, Mohamed H, Kumar AU. Short-term musical training and psychoacoustical abilities. Audiology Res 2014; 4 (01) 102
    CrossrefPubMedSearch in Google Scholar
  • 22 Nuttall AL. Sound-Induced Cochlear Ischemia/Hypoxia as a Mechanism of Hearing Loss. Noise Health 1999; 2 (05) 17-32
    PubMedSearch in Google Scholar
  • 23 Haas JD, Brownlie IV T. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 2001; 131 (2S-2, 2S) 676S-688S , discussion 688S–690S.
    CrossrefPubMedSearch in Google Scholar
  • 24 Manwani D, Frenette PS. Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Blood 2013; 122 (24) 3892-3898
    CrossrefPubMedSearch in Google Scholar
  • 25 Quinn CT. Minireview: Clinical severity in sickle cell disease: the challenges of definition and prognostication. Exp Biol Med (Maywood) 2016; 241 (07) 679-688
    CrossrefPubMedSearch in Google Scholar
  • 26 Olsho LW, Koch EG. Frequency and practice interactions in frequency discrimination. J Acoust Soc Am 1986; 79 (S1): S79
    CrossrefSearch in Google Scholar