Análise do perfil metabólico do líquido sinovial de pacientes com osteoartrite do joelho por meio da metabolômica por ressonância magnética espectroscópica

Resumo

Objetivo Avaliar o perfil metabólico do líquido sinovial de pacientes com osteoartrite do joelho (OAJ) correlacionando com os dados clínicos.

Métodos Coletamos amostras de líquido sinovial do joelho de 50 indivíduos com OAJ durante artroplastia total do joelho entre outubro de 2019 e dezembro de 2020. Avaliamos, para cada paciente, os dados clínicos do prontuário médico, o grau de artrose radiográfica e a glicemia de jejum pré-operatória. As amostras foram submetidas à análise metabolômica por ressonância magnética (RM) 1H, e os espectros foram comparados por meio de análises multivariadas e univariadas.

Resultados O sexo feminino prevaleceu (66%), a média de idade foi 67,96 ± 7,08 anos e a média do índice de massa corporal (IMC) foi de 32,51 ± 5,25 kg/m2. Nas avaliações clínicas e metabólicas, 88% dos pacientes eram hipertensos, e encontramos maiores níveis de valina, arginina e citrato em comparação com pacientes não hipertensos.

Conclusão A análise metabolômica do líquido sinovial não conseguiu classificar os pacientes com OA de acordo com as características clínicas.

Palavras-chave

espectroscopia de ressonância magnética - líquido sinovial - metabolômica - osteoartrite

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