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CC BY-NC-ND 4.0 · South Asian J Cancer 2025; 14(02): 208-210
DOI: 10.1055/s-0044-1790221
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Quality of Life Section

Challenges in Targeting the “Crosstalks” in Cancer Cachexia

Authors

  • Dilip Harindran Vallathol

    1   Department of Medical Oncology, Aster Medcity, Cochin, Kerala, India

  • Arun R. Warrier

    1   Department of Medical Oncology, Aster Medcity, Cochin, Kerala, India
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Abstract

Cancer cachexia syndrome is characterized by involuntary weight loss which usually occurs in advanced malignancies. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The syndrome is closely related to the prognostication of malignancies. Several research works are in progress to target the major effectors of cancer cachexia syndrome. This letter is a nutshell on the current status of the cancer cachexia syndrome—the crosstalks and potential therapeutic targets.

Keywords

adipose tissue - cancer cachexia - central nervous system - skeletal muscle - tumor environment


Publication History

Received: 30 July 2024

Accepted: 03 August 2024

Article published online:
02 September 2024

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