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CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0044-1790221
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Challenges in Targeting the “Crosstalks” in Cancer Cachexia

Dilip Harindran Vallathol
1   Department of Medical Oncology, Aster Medcity, Cochin, Kerala, India
,
Arun R. Warrier
1   Department of Medical Oncology, Aster Medcity, Cochin, Kerala, India
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Abstract

Cancer cachexia syndrome is characterized by involuntary weight loss which usually occurs in advanced malignancies. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The syndrome is closely related to the prognostication of malignancies. Several research works are in progress to target the major effectors of cancer cachexia syndrome. This letter is a nutshell on the current status of the cancer cachexia syndrome—the crosstalks and potential therapeutic targets.

Keywords

adipose tissue - cancer cachexia - central nervous system - skeletal muscle - tumor environment


Publication History

Received: 30 July 2024

Accepted: 03 August 2024

Article published online:
02 September 2024

© 2024. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Pryce BR, Wang DJ, Zimmers TA, Ostrowski MC, Guttridge DC. Cancer cachexia: involvement of an expanding macroenvironment. Cancer Cell 2023; 41 (03) 581-584
    CrossrefPubMedGoogle Scholar
  • 2 Kadakia KC, Hamilton-Reeves JM, Baracos VE. Current therapeutic targets in cancer cachexia: a pathophysiologic approach. Am Soc Clin Oncol Educ Book 2023; 43: e389942
    CrossrefPubMedGoogle Scholar
  • 3 Mavropalias G, Sim M, Taaffe DR. et al. Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects. J Cancer Res Clin Oncol 2022; 148 (06) 1389-1406
    CrossrefPubMedGoogle Scholar
  • 4 Wang Y, Dong Z, An Z, Jin W. Cancer cachexia: focus on cachexia factors and inter-organ communication. Chin Med J (Engl) 2024; 137 (01) 44-62
    CrossrefPubMedGoogle Scholar
  • 5 Liu M, Ren Y, Zhou Z. et al. The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia. Cancer Cell 2024; 42 (05) 885-903.e4
    CrossrefPubMedGoogle Scholar