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CC BY 4.0 · Chinese medicine and natural products 2024; 04(03): e93-e105
DOI: 10.1055/s-0044-1790228
Review Article

Mechanisms and Research Progress of Traditional Chinese Medicine Regulating NF-κB in the Treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome

Wanzhao Zuo
1   College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, China
,
Fanian Tian
2   Department of Pulmonary Diseases, Hubei Provincial Academy of Traditional Chinese Medicine of The Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China
,
Jia Ke
2   Department of Pulmonary Diseases, Hubei Provincial Academy of Traditional Chinese Medicine of The Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China
,
Cheng Jiang
2   Department of Pulmonary Diseases, Hubei Provincial Academy of Traditional Chinese Medicine of The Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China
,
Yi Yang
2   Department of Pulmonary Diseases, Hubei Provincial Academy of Traditional Chinese Medicine of The Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China
,
Cong He
2   Department of Pulmonary Diseases, Hubei Provincial Academy of Traditional Chinese Medicine of The Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China
› Author Affiliations Funding This work was supported by the Construction Project of Tu Jinwen National Chinese Medical Master Inheritance Studio of National Administration of Traditional Chinese Medicine (National TCM Education Letter [2022] No. 245), and Hubei Province Public Health Youth Top Talents Training Program (Hubei Health Notice [2021] No. 74).
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Abstract

Acute lung injury (ALI) has multiple causes and can easily progress to acute respiratory distress syndrome (ARDS) if not properly treated. Nuclear factor κB (NF-κB) is a key pathway in the treatment of ALI/ARDS. By exploring the relevance of NF-κB and the pathogenesis of this disease, it was found that this disease was mainly associated with inflammation, dysfunction of the endothelial barrier, oxidative stress, impaired clearance of alveolar fluid, and coagulation disorders. Traditional Chinese medicine (TCM) has the characteristics of multitargeting, multipathway effects, and high safety, which can directly or indirectly affect the treatment of ALI/ARDS. This article summarizes the mechanism and treatment strategies of TCM in recent years through intervention in the NF-κB-related signaling pathways for treating ALI/ARDS. It provides an overview from the perspectives of Chinese herbal monomers, TCM couplet medicines, TCM injections, Chinese herbal compounds, and Chinese herbal preparations, offering insights into the prevention and treatment of ALI/ARDS with TCM.

Keywords

acute lung injury - acute respiratory distress syndrome - traditional Chinese medicine - NF-κB

CRediT Authorship Contribution

Wanzhao Zuo: conceptualization, data curation, and writing—original draft. Fanian Tian: visualization and formal analysis. Jia Ke: funding acquisition. Cheng Jiang: data curation. Yi Yang: funding acquisition and project administration. Cong He: supervision, funding acquisition, and writing—review and editing.




Publication History

Received: 15 April 2024

Accepted: 22 June 2024

Article published online:
30 September 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Kryvenko V, Vadász I. Alveolar-capillary endocytosis and trafficking in acute lung injury and acute respiratory distress syndrome. Front Immunol 2024; 15: 1360370
    CrossrefPubMedSearch in Google Scholar
  • 2 Ma XC, Wang C, Fang Q. et al; Chinese Society of Critical Care Medicine, Chinese Medical Association. [Guidelines for management of acute lung injury/acute respiratory distress syndrome: an evidence-based update by the Chinese Society of Critical Care Medicine (2006)]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006; 18 (12) 706-710
    PubMedSearch in Google Scholar
  • 3 Zhang S, Hagens LA, Heijnen NFL. et al; DARTS Consortium. Breath metabolomics for diagnosis of acute respiratory distress syndrome. Crit Care 2024; 28 (01) 96
    CrossrefPubMedSearch in Google Scholar
  • 4 Tang N, Yang Y, Xie Y. et al. CD274 (PD-L1) negatively regulates M1 macrophage polarization in ALI/ARDS. Front Immunol 2024; 15: 1344805
    CrossrefPubMedSearch in Google Scholar
  • 5 Mowery NT, Terzian WTH, Nelson AC. Acute lung injury. Curr Probl Surg 2020; 57 (05) 100777
    CrossrefPubMedSearch in Google Scholar
  • 6 Dai Q, Xu TX, Wang XX. et al. Current status and reunderstanding of drug therapy for ALI/ARDS. Inner Mongolia Med J 2023; 55 (11) 1314-1318
    Search in Google Scholar
  • 7 Huang Q, Le Y, Li S, Bian Y. Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS). Respir Res 2024; 25 (01) 30
    CrossrefPubMedSearch in Google Scholar
  • 8 Peng J, Tang R, He J, Yu Q, Wang D, Qi D. S1PR3 inhibition protects against LPS-induced ARDS by inhibiting NF-κB and improving mitochondrial oxidative phosphorylation. J Transl Med 2024; 22 (01) 535
    CrossrefPubMedSearch in Google Scholar
  • 9 Shi L, Huang WJ. Recent advances in the treatment of nuclear factor κB and pneumonia. Int J Respir 2009; 29 (04) 231-233
    Search in Google Scholar
  • 10 Aishanjiang RZ, Zhang Q, Amanguli MM. et al. Effect of nuclear transcription factor-κB (NF-κB) on annexin A2 (ANXA2) expression in lipopolysaccharides (LPS)-induced acute lung injury (ALI) in mice with sepsis. Xinjiang Yike Daxue Xuebao 2024; 47 (06) 798-803
    Search in Google Scholar
  • 11 He WD, Wen D, Wu H. et al. Influence of purging Fire and removing Toxin therapy on related factors of vascular endothelial cells NF-κB signaling pathway in Trimeresurus Stejnegeri bites. Zhonghua Zhongyiyao Xuekan 2018; 36 (01) 34-37
    Search in Google Scholar
  • 12 Lingappan K. NF-κB in oxidative stress. Curr Opin Toxicol 2018; 7: 81-86
    CrossrefPubMedSearch in Google Scholar
  • 13 Zhai Y, Yu T, Xin S. et al. Network pharmacology-based research into the mechanism of ferulic acid on acute lung injury through enhancing transepithelial sodium transport. J Ethnopharmacol 2024; 330: 118230
    CrossrefPubMedSearch in Google Scholar
  • 14 Gouda MM, Shaikh SB, Bhandary YP. Inflammatory and fibrinolytic system in acute respiratory distress syndrome. Lung 2018; 196 (05) 609-616
    CrossrefPubMedSearch in Google Scholar
  • 15 Tao SY, Li Y, Chen K. et al. Research progress on pathological mechanism of acute lung injury based on NF-κB signaling pathway and TCM intervention. Pharmacol Clin Chin Mater Med 2024; 1-22
    Search in Google Scholar
  • 16 Richard HS, Clayton BD, David CJ. et al. Regulation of endothelialthrombomodulin expression inflammatory cytokines is mediated by activation of nuclearfactor-kappa. B.Blood 2005; 105 (05) 3910-3918
    Search in Google Scholar
  • 17 Li L, Wang YX, Yang GM. et al. Effect of Fibrauretin on the protein expression and activation of NF-κB in lung tissues of mice with acute lung injury. Guiding J Tradit Chin Med Pharm 2019; 16 (19) 7-10
    Search in Google Scholar
  • 18 Kan X, Chen Y, Huang B. et al. Effect of Palrnatine on lipopolysaccharide-induced acute lung injury by inhibiting activation of the AKT/NF-κB pathway. J Zhejiang Univ Sci B 2021; 22 (11) 929-940
    CrossrefPubMedSearch in Google Scholar
  • 19 Hong L. Coptisine ameliorates LPS-induced acute lung injury through its anti-inflammatory activity by inhibition of the PI3K/AKT/NF-κB pathway. Liaoning: China Medical University; 2019
    Search in Google Scholar
  • 20 Liu CX, He SQ, Zhan JH. Protective effect of Ligustrazine on acute lung injury in severely burned rats and its effect on NF-κB/NLRP3 signaling pathway. Chin Pharm 2019; 28 (17) 22-25
    Search in Google Scholar
  • 21 Liu C, Zhen D, Du H. et al. Synergistic anti-inflammatory effects of peimine, peiminine, and forsythoside a combination on LPS-induced acute lung injury by inhibition of the IL-17-NF-κB/MAPK pathway activation. J Ethnopharmacol 2022; 295: 115343
    CrossrefPubMedSearch in Google Scholar
  • 22 Wu Y, Nie Y, Huang J. et al. Protostemonine alleviates heat-killed methicillin-resistant Staphylococcus aureus-induced acute lung injury through MAPK and NF-κB signaling pathways. Int Immunopharmacol 2019; 77: 105964
    CrossrefPubMedSearch in Google Scholar
  • 23 Wang L. Mechanism of hederagenin alleviating lipopolysaccharide-induced acute lung injury by regulating NF-κB/NLRP3 inflammasome. Liaoning: China Medical University; 2023
    Search in Google Scholar
  • 24 Chen CY. The mechanism of DA in Cimicifugae Rhizoma alleviating acute lung injury induced by lipopolysaccharide in mice based on IκBα/NF-κB and MAPKs/AP-1 signaling pathways. Tianjin: Tianjin University of Traditional Chinese Medicine; 2023
    Search in Google Scholar
  • 25 Zhang J, Wang C, Wang H. et al. Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation. Int Immunopharmacol 2021; 95: 107529
    CrossrefPubMedSearch in Google Scholar
  • 26 Zhang Q, Zhu S, Cheng X. et al. Euphorbia factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation in mice through the suppression of NF-κB activation. Biochem Pharmacol 2018; 155: 444-454
    CrossrefPubMedSearch in Google Scholar
  • 27 Wang X, Zhang L, Duan W. et al. Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model. Mol Med Rep 2014; 10 (01) 447-452
    CrossrefPubMedSearch in Google Scholar
  • 28 Qu LY. Protective effect of AEP on acute lung injury in mice and its antiinflammatory mechanism through TAK1/NF-κB pathway. Henan: Henan University; 2023
    Search in Google Scholar
  • 29 Chen YX, Wang N, Xu LL. et al. Kumquat essential oil inhibits lipopolysaccharide-induced acute lung injury by suppressing p38 MAPK and NF-κB signaling pathways in mice. Acta Acad Med Guangxi 2019; 36 (06) 863-868
    Search in Google Scholar
  • 30 Li YH, Zhao M. Progress in Toll-like receptor signal transduction pathway and acute lung injury. Chin J Immunol 2021; 37 (01) 115-118
    Search in Google Scholar
  • 31 Zhao JQ, Bao YZ, Han CH. Effects of Biobalide on TLR4/NFκB signaling pathway and Th1/Th2 cells in rats with sepsis induced acute lung injury. Med J West China 2021; 37 (01) 115-118
    Search in Google Scholar
  • 32 Pei CX, Wang ZX, Wang XM. et al. Platycodin D attenuates lipopolysaccharide-induced acute lung injury via NF-κB signaling pathway in rats. Chin J Pathophysiol 2022; 38 (04) 672-679
    Search in Google Scholar
  • 33 Peng D, Chen Y, Sun Y. et al. Saikosaponin A and its epimers alleviate LPS-induced acute lung injury in mice. Molecules 2023; 28 (03) 967
    CrossrefPubMedSearch in Google Scholar
  • 34 Yang LK. Protective effect of baicalin magnesium salt on LPS-induced acute lung injury in mice. Hebei: Chengde Medical University; 2022
    Search in Google Scholar
  • 35 Wu WJ, Liu CN, Cai HY. Relationship between oxidative stress and acute lung injury. Chin Foreign Med Res 2022; 20 (33) 177-181
    Search in Google Scholar
  • 36 Zhang QZ, Cao B, Liang ZY. Silymarin improves lung function of rats with acute lung injury by regulating TLR/NF-κB signaling pathway. J Emerg Tradit Chin Med 2019; 28 (05) 809-813
    Search in Google Scholar
  • 37 Liu DD, Cao G, Zhang Q. et al. Trifolium flavone inhibits acute lung injury in aged mice via p38MAPK and NF-κB pathways. Chin Pharmacol Bull 2015; 31 (12) 1725-1730
    Search in Google Scholar
  • 38 Zhu HB, Fang J, Tang ML. et al. The effects of ampelopsin on lipopolysaccharide-induced acute lung injury mice and the TLR4/MyD88/NF-κB signaling pathway. Hubei Agric Sci 2023; 62 (05) 118-123
    Search in Google Scholar
  • 39 Ren X. Protective effects of polymethoxyflavones extract from Citrus reticulata 'chachi' on acute lung injury induced by lipopolysaccharide in mice. Hubei: Huazhong Agricultural University; 2021
    Search in Google Scholar
  • 40 Liu JH, Cao L, Zhang CH. et al. Dihydroquercetin attenuates lipopolysaccharide-induced acute lung injury through modulating FOXO3-mediated NF-κB signaling via miR-132-3p. Pulm Pharmacol Ther 2020; 64: 101934
    CrossrefPubMedSearch in Google Scholar
  • 41 Zhang XS. Halofuginone ameliorates LPS-induced immune disorder of acute lung injury via CD14/NF-κB pathway. Chin J Immunol 2018; 34 (06) 861-865
    Search in Google Scholar
  • 42 Zhong X, Tang GQ, Liu Q. et al. Protective effect of isorhamnetin on hyperoxia-induced acute lung injury in rats by regulating TLR4/NF-κB signaling pathway. Chin J Immunol 2023; 39 (09) 1797-1802
    Search in Google Scholar
  • 43 Li JM, Sheng Y, Hong ZX. et al. Protective effect of cordycepin on lipopolysaccharide-induced acute lung injury in a rat model by regulation of the TLR4/NF-κB pathway activity. Zhejiang J Integr Tradit Chin West Med 2022; 32 (11) 991-996
    Search in Google Scholar
  • 44 Liu L. Study on the mechanism of saponins from Allium macrostemon bunge on acute lung injury bunge in mice based on NF-κB/VCAM-1 pathway. Jiangxi: Jiangxi University of Traditional Chinese Medicine; 2023
    Search in Google Scholar
  • 45 Ren Y. Effect of tonify qi, purge turbidity and activate blood formula on high-risk patients of acute lung injury: a clinical study. Guangdong: Guangzhou University of Chinese Medicine; 2021
    Search in Google Scholar
  • 46 Cui G, Li Q, Shu WF. et al. Panax notoginseng saponins ameliorated LPS-induced acute lung injury in mice by inhibiting the activation of NF-κB. Yao Xue Xue Bao 2022; 57 (12) 3587-3595
    Search in Google Scholar
  • 47 Xu HL. Study on the therapeutic effect and mechanism of panax ginseng and its active constituents on lipopolysaccharide-induced acute lung injury in mice based on TLR4/NF-κB/MAPK signaling pathway. Guangdong: Southern Medical University; 2023
    Search in Google Scholar
  • 48 Wang ZC. Protective effects of Astragaloside IV against small particulate matter-induced acute lung injury in rats through an inhibition of Rho A/ROCK/NF-κB signaling. Sichuan: Chengdu University of TCM; 2020
    Search in Google Scholar
  • 49 Zhang ZY, Lu RF, Huang XM. et al. Effects of Salidroside on expressions of Toll -like receptor 4 and nuclear factor-κB in lung tissue of Paraquat poisoning rats. Zhonghua Zhongyiyao Xuekan 2014; 32 (06) 1357-1360
    Search in Google Scholar
  • 50 Wan ZH, Zeng L, Zhou H. et al. Protective effect of polyphyllin VII on acute lung injury in rats with severe acute pancreatitis by inhibiting NF-κB signaling pathway. J Jilin Univ 2022; 48 (03) 668-675 (Med Ed)
    Search in Google Scholar
  • 51 Yu Y, Sun YJ, Zhou N. Protective effect and possible mechanism of Osthole on acute lung injury in rat with hemorrhagic shock. Prog Anat Sci 2019; 25 (02) 118-122
    Search in Google Scholar
  • 52 Song TR, Chen F, Dong MQ. et al. The anti-inflammatory effect of Arctiin on acute respiratory distress syndrome (ARDS) vitro model and the effect of PI3K AKT-NF-кB signaling pathway. J Zhejiang Chin Med Univ 2022; 46 (06) 623-628
    Search in Google Scholar
  • 53 Lee HC, Liu FC, Tsai CN. et al. Esculetin ameliorates lipopolysaccharide-induced acute lung injury in mice via modulation of the AKT/ERK/NF-κB and RORγt/IL-17 pathways. Inflammation 2020; 43 (03) 962-974
    CrossrefPubMedSearch in Google Scholar
  • 54 Yang LY. Mechanism study of Eupalinolide B attenuates acute lung injury through regulation of NF-κB and MAPKs signaling by targeting the biomarker TAK1. Sichuan: Chengdu University of TCM; 2023
    Search in Google Scholar
  • 55 Xiao L, Gao CL, Guo W. et al. Codonopsis polysaccharide protected LPS-induced acute lung injury by inhibiting MAPK/NF-κB signaling pathway in mice. J Pract Med 2024; 40 (07) 948-954
    Search in Google Scholar
  • 56 Sun SX. A study on the mechanism of Chicory acid in improving acute lung injury in sepsis by regulating TLR9/NF-κB. Shandong: Shandong University of Traditional Chinese Medicine; 2023
    Search in Google Scholar
  • 57 Liu F, Yang Y, Dong H. et al. Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-κB pathway. Phytomedicine 2024; 129: 155651
    CrossrefPubMedSearch in Google Scholar
  • 58 Niu X, Zang L, Li W. et al. Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute lung injury via the NLRP3 and NF-κB/TLR4 signaling pathway. Int Immunopharmacol 2020; 81: 106024
    CrossrefPubMedSearch in Google Scholar
  • 59 Wang JC. Protective effect of 6-Shogaol against LPS induced acute lung injury in mice via attenuating NF-κB: a mechanistic study. Guangdong: Southern Medical University; 2016
    Search in Google Scholar
  • 60 Li Q, Gu JR, Xiao C. et al. Effects of gingerol on alveolar hypercoagulation and fibrinolytic inhibition in rats with LPS-induced acute respiratory distress syndrome. J Pract Med 2023; 39 (10) 1218-1223
    Search in Google Scholar
  • 61 Li LH, Zhang YQ, Hao J. et al. Effect of tanshinone IIA sulfoacid sodium on NF-κB expression in lung tissue in the treatment of guinea pig with acute lung injury caused by explosion. J Clin Pulm Med 2015; 20 (11) 1991-1995
    Search in Google Scholar
  • 62 Zhang J, Liu ZX, Jia BX. et al. Lung injury during sepsis induction in mice pre-injected intraperitoneally with resveratrol and curcumin. Shandong Yiyao 2023; 63 (06) 42-47
    Search in Google Scholar
  • 63 Deng D, Tan HL, Shangguan YL. et al. Effects of pine cone of Pinus yunnanensis on inflammation and oxidative stress of rats with LPS-induced acute lung injury. Zhongchengyao 2021; 43 (07) 1721-1726
    Search in Google Scholar
  • 64 Chen LY, Yin L, Zhou MJ. et al. Effect of Euphorbia helioscopia alcohol extract on MAPK/NF-κB inflammation pathway on mice with acute lung injury induced by LPS. Chin J Exp Tradit Med Formul 2020; 26 (20) 46-51
    Search in Google Scholar
  • 65 Jiao Y, Zhou L, Li H. et al. A novel flavonol-polysaccharide from Tamarix chinensis alleviates influenza A virus-induced acute lung injury. Evidences for its mechanism of action. Phytomedicine 2024; 125: 155364
    CrossrefPubMedSearch in Google Scholar
  • 66 Shi K, Xiao Y, Dong Y. et al. Protective effects of Atractylodis lancea rhizoma on lipopolysaccharide-induced acute lung injury via TLR4/NF-κB and Keap1/Nrf2 signaling pathways in vitro and in vivo. Int J Mol Sci 2022; 23 (24) 16134
    CrossrefPubMedSearch in Google Scholar
  • 67 Rao ZL. Exploring the anti-acute lung injury effects and mechanism of Jing-Fang N-butanol and its isolated fractions JFNE-A. Sichuan: Chengdu University of TCM; 2022
    Search in Google Scholar
  • 68 Wang Z, Yan SG, Hui Y. et al. The mechanism of ephedra-rheum officinale on preventing and treating acute lung injury by inhibiting the polarization of alveolar macrophage M1. Chin Pharmacol Bull 2022; 38 (09) 1421-1429
    Search in Google Scholar
  • 69 Huang Y, Yao ME, Dong QQ. et al. Study on the mechanism of Radix Astragali-Salvia Miltiorrhiza on sepsis based on network pharmacology and molecular docking. World Clin Drug 2021; 42 (05) 401-411
    Search in Google Scholar
  • 70 Qin L. Astragalus membranaceus and Salvia miltiorrhiza ameliorate acute lung injury based on the toll-like receptor 4/nuclear factor-kappa B signaling pathway. Beijing: Chinese People's Liberation Army (PLA) Medical School; 2018
    Search in Google Scholar
  • 71 Li M, Shao HZ. Clinical study on Reduning Injection combined with piperacillin sodium and tazobactam sodium in treatment of severe pneumonia. Mod Drugs Clinic 2022; 37 (12) 2790-2794
    Search in Google Scholar
  • 72 You LJ, Yuan L, Yang XF. et al. Effect of Reduning Injection on TLR4/MyD88/NF-κB pathway in LPS-induced ALI/ARDS mice. Zhongchengyao 2023; 45 (05) 1625-1629
    Search in Google Scholar
  • 73 Wang K, Liu XH. Effect of Chuankezhi injection on TLR4 /NF-κB/NLRP3 pathway in mice with acute lung injury. Chin J Exp Tradit Med Formul 2017; 23 (22) 143-148
    Search in Google Scholar
  • 74 Ma D, Bao XL, Ye S. et al. Effect of compound Danshen injection on CYLD/NF-κB signal in rats with severe acute pancreatitis-acute lung injury. J Emerg Tradit Chin Med 2018; 27 (12) 2098-2102
    Search in Google Scholar
  • 75 Yan L, Lai Y. Effects of Tanreqing injection on NF-κB of acute lung injury induced by Endotoxin in rats lung lissue. J Emerg Tradit Chin Med 2015; 24 (01) 38-41
    Search in Google Scholar
  • 76 Zhang YF, Zang BH, Li X. et al. Effect of sofren injection on NF-κB expression in acute lung injury mice with sepsis. J Clin Pulm Med 2017; 22 (12) 2147-2150
    Search in Google Scholar
  • 77 Liu ZC, Wu D, Wang G. et al. Effect of Ginaton injection on the expression of NF-κB in rats with acute lung injury induced by LPS. Anhui Yiyao 2015; 19 (12) 2288-2291
    Search in Google Scholar
  • 78 Xu XF, Xu XJ, Hao J. et al. The value of Xuebijing Injection on the rehabilitation of rabbits with acute lung injury induced by firearm injury and the effect on the expression of NF-κB in lung tissue. Chin Med Her 2017; 14 (31) 19-23
    Search in Google Scholar
  • 79 He M, Shen YH, Xiong XD. et al. Study on time-effect relationship of impact of Yantiao-prescription on NF-κB signaling pathway in rats with acute lung injury induced by sepsis. Yaowu Pingjia Yanjiu 2020; 43 (12) 2410-2415
    Search in Google Scholar
  • 80 Wei ZY, Ren XP, Zhang Y. et al. Effect of Qingfu Tongchang Granule on TNF-α and NF-κB p65 in ALI rats. Mod Tradit Chin Med 2020; 40 (06) 20-24
    Search in Google Scholar
  • 81 Ding W, Wang WL, He ZZ. et al. Anti-inflammatory and protective effect of Linggui Zhugantang on LPS-induced acute lung injury in mice via NF-κB signaling pathway. Chin J Exp Tradit Med Formul 2023; 29 (15) 14-21
    Search in Google Scholar
  • 82 Shen T. Effect and mechanism of Jinyin Qingre liquid on LPS-induced acute lung injury in mice. Hubei: Hubei University of Chinese Medicine; 2020
    Search in Google Scholar
  • 83 Zhou ZL. Study on the mechanism of Fusu mixture in the treatment of extrapulmonary acute respiratory distress syndrome based on transcriptome analysis. Sichuan: Chengdu University of TCM; 2023
    Search in Google Scholar
  • 84 Zhou XJ, Zhang L, Zhang CT. et al. Exploration on the mechanism of Fusu mixture regulating sepsis-related ARDS based on mRNA/lncRNA expression profiles. Chin J Tradit Chin Med Pharm 2022; 37 (08) 4297-4302
    Search in Google Scholar
  • 85 Zhang L. Based on TLR4/MyD88/NF-κB signal pathway to explore the mechanism of Yiqi Kangfei Formula on acute lung injury. Shaanxi: Shaanxi University of Chinese Medicine; 2023
    Search in Google Scholar
  • 86 Fang J. Study on the quality attributes of Shengjiang Powder and its effect and mechanism on improving acute lung injury in mice. Jilin: Changchun University of Chinese Medicine; 2024
    Search in Google Scholar
  • 87 Wang K, Pan JH, Wang P. Effect of Qingfei Litan decoction on NF-κB and TLR4 expressions in LPS-induced rats with acute lung injury. J Emerg Tradit Chin Med 2016; 25 (06) 1001-1004
    Search in Google Scholar
  • 88 Ling X, Xu W, Pang G. et al. Tea polyphenols ameliorates acute lung injury in septic mice by inhibiting NLRP3 inflammasomes. Nan Fang Yi Ke Da Xue Xue Bao 2024; 44 (02) 381-386
    PubMedSearch in Google Scholar
  • 89 Ma YH. Study on the mechanism of Yiqi Huayu Jiedu prescription in the intervention of ARDS based on TLR4/NF-κB/NLRP3 pathway. Beijing: Beijing University of Chinese Medicine; 2020
    Search in Google Scholar
  • 90 Zhang Q. Study on the effect and mechanism of Shiwei Qingwen decoction on acute lung injury in rats based on TLR4/NF-κB/NLRP3 signaling pathway. Hubei: Hubei University of Chinese Medicine; 2023
    Search in Google Scholar
  • 91 Hou WQ, Liu DL, Hai Y. et al. Maxing Shigan Decoction alleviates the inflammatory response of LPS-induced acute lung injury by regulating MAPK/NF-κB pathway. Pharm Clin Chin Mater Med 2023; 39 (03) 1-7
    Search in Google Scholar
  • 92 Wang ZJ. The role of gut microbiome in the pathogenesis of severe acute pancreatitis-associated acute lung injury and the intervention of Qingyi decoction. Liaoning: Dalian Medical University; 2023
    Search in Google Scholar
  • 93 Ma YM, Zhao LJ, Liu MR. et al. Multiple components of Mahuang Shengma Decoction on prevention and treatment of acute lung injury based on RAGE/NF-κB signaling pathway. Zhongguo Zhongyao Zazhi 2021; 46 (21) 5693-5700
    PubMedSearch in Google Scholar
  • 94 Wang GQ, Li S, Yu LZ. et al. Study on the protective effect and mechanism of Qingwen Baidudu Drink on acute lung injury in rats with sepsis based on JAK2/STAT3 and IKKα/NF-κB signaling pathways. Pharmacol Clin Chin Mater Med 2018; 34 (03) 2-5
    Search in Google Scholar
  • 95 Zong SB, Sun L, Lyu YZ. et al. Effect of Jinzhen oral liquid on NF-κB, MAPK signaling pathway in mice with LPS-induced acute lung injury. Chin J Exp Tradit Med Formul 2018; 24 (09) 155-159
    Search in Google Scholar
  • 96 Hong HH, Yang QC, Cai WR. Effects of Qidong Huoxue Decoction on Caveolin-1/NF-κB inflammation signal pathway in acute lung injury rats. Chin J Tradit Chin Med Pharm 2016; 31 (01) 239-243
    Search in Google Scholar