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CC BY-NC-ND 4.0 · J Pediatr Infect Dis 2024; 19(06): 317-326
DOI: 10.1055/s-0044-1790288
Original Article

Outcome of Children with Congenital Cytomegalovirus Infection: A Retrospective Observational Study

Chiara Mardegan 
1   Division of Pediatric Intensive Care and Neonatology, Department of Women, Children and Adolescents, University Hospitals of Geneva, Geneva, Switzerland
,
Helene Cao Van
2   Division of Otorhinolaryngology, Department of Clinical Neurosciences, University Hospitals of Geneva, Geneva, Switzerland
,
Sylviane Hanquinet
3   Pediatric Radiology Unit, Diagnostic Department, University Hospitals of Geneva, Geneva, Switzerland
,
Cristina Borradori Tolsa
4   Division of Development and Growth, Department of Women, Children and Adolescents, University Hospital of Geneva, Geneva, Switzerland
,
Laure F. Pittet
5   Division of General Pediatrics, Department of Women, Children and Adolescents, University Hospitals of Geneva, Geneva, Switzerland
,
Klara M. Posfay-Barbe
5   Division of General Pediatrics, Department of Women, Children and Adolescents, University Hospitals of Geneva, Geneva, Switzerland
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Abstract

Objective Congenital cytomegalovirus (CMV) infection is a common intrauterine infection and the leading cause of nonhereditary sensorineural hearing loss. This study aims to assess the long-term outcome of the infection and to identify infants at risk of developing long-term sequelae.

Methods This retrospective single-center observational study includes infants born between 2003 and 2019 with confirmed congenital CMV (based on current criteria). Brain imaging (ultrasound and magnetic resonance imaging [MRI]), clinical monitoring of neurosensory development, and auditory brainstem evoked responses were performed, as well as long-term neurodevelopmental follow-up to assess sequelae.

Results A total of 66 infants with congenital CMV were included in the study. Median gestational age at birth was 38.6 weeks (interquartile range: 36.9–40.1). Clinical findings included intrauterine growth restriction (39%), microcephaly (29%), thrombocytopenia (17%), and jaundice (11%). Brain abnormalities were observed on ultrasound (30%) and MRI (42%). Neurodevelopmental scores were abnormal in 21 subjects (43%) and associate with the vacuolization of anterior temporal lobe and ventricular septations on MRI (both p = 0.05). Fourteen patients (21%) had sensorineural hearing loss, which was more common in patients with abnormal cerebral images at birth, determined by ultrasound (p = 0.06). Microcephaly (p = 0.05) and abnormal MRI (p = 0.03) at birth were associated with poor long-term outcomes.

Conclusion Early detection of congenital CMV infection is important to prevent long-term complications in affected infants. Understanding the predictors of poor outcomes may help improving management and treatment strategies for this condition.

Keywords

congenital infection - cytomegalovirus - long-term sequelae


Publikationsverlauf

Eingereicht: 25. Oktober 2023

Angenommen: 19. August 2024

Artikel online veröffentlicht:
04. Oktober 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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