Arquivos de Neuro-Psiquiatria, Table of Contents CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(07): s00441790571DOI: 10.1055/s-0044-1790571 Editorial Migraine with aura, thrombophilia, and the debate on white matter hyperintensities Enxaqueca com aura, trombofilia e o debate sobre hiperintensidades da substância branca Raffaele Ornello 1 University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy. , Federico De Santis 1 University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy. , Matteo Foschi 1 University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy. › Author Affiliations Recommend Article Abstract Bibliographical Record Raffaele Ornello, Federico De Santis, Matteo Foschi. Migraine with aura, thrombophilia, and the debate on white matter hyperintensities. Arq Neuropsiquiatr 2024; 82: s00441790571. DOI: 10.1055/s-0044-1790571 Full Text References References 1 Hamedani AG, Rose KM, Peterlin BL. et al. Migraine and white matter hyperintensities: the ARIC MRI study. Neurology 2013; 81 (15) 1308-1313 . Doi: 10.1212/WNL.0b013e3182a8235b 2 Eikermann-Haerter K, Huang SY. White Matter Lesions in Migraine. Am J Pathol 2021; 191 (11) 1955-1962 . Doi: 10.1016/j.ajpath.2021.02.007 3 Sacco S, Ricci S, Carolei A. Migraine and vascular diseases: a review of the evidence and potential implications for management. Cephalalgia 2012; 32 (10) 785-795 . Doi: 10.1177/0333102412451361 4 Øie LR, Kurth T, Gulati S, Dodick DW. Migraine and risk of stroke. J Neurol Neurosurg Psychiatry 2020; 91 (06) 593-604 . Doi: 10.1136/jnnp-2018-318254 5 Yılmaz Can F. Investigation of the relationship between thrombophilic disorders and brain white matter lesions in migraine with aura. Arq Neuropsiquiatr 2024; 82 (07) 1 . Doi: 10.1055/s-0044-1787762 6 Cavestro C, Degan D, Micca G. et al. Thrombophilic alterations, migraine, and vascular disease: results from a case-control study. Neurol Sci 2021; 42 (09) 3821-3828 . Doi: 10.1007/s10072-020-05006-z 7 Sacco S, Harriott AM, Ayata C. et al. Microembolism and Other Links Between Migraine and Stroke: Clinical and Pathophysiologic Update. Neurology 2023; 100 (15) 716-726 . Doi: 10.1212/WNL.0000000000201699 8 Schwedt TJ, Demaerschalk BM, Dodick DW. Patent foramen ovale and migraine: a quantitative systematic review. Cephalalgia 2008; 28 (05) 531-540 . Doi: 10.1111/j.1468-2982.2008.01554.x 9 Zhang Y, Wang H, Liu L. Patent Foramen Ovale Closure for Treating Migraine: A Meta-Analysis. J Interv Cardiol 2022; 2022: 6456272 . Doi: 10.1155%2F2022%2F6456272