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Clin Colon Rectal Surg
DOI: 10.1055/s-0044-1791283
Review Article

Structural Alterations in Diverticular Disease

Kerri Lopez
1   Division of Colon and Rectal Surgery, Department of Surgery, University of Maryland, Baltimore, Maryland
,
Lillias H. Maguire
2   Division of Colon and Rectal Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Pennsylvania
3   Department of Surgery, Corporal Michael J. Crescenz Veterans Administration Medical Center, Philadelphia, Pennsylvania
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Abstract

Clinicians appreciate the structural alterations of diverticular disease when navigating narrow, angulated colons with a colonoscope or removing stiff, fixed sigmoid colons at surgery. Investigation of these tissues reveals increased thickness of smooth muscle, alterations in the amount and structure of the extracellular matrix, and changes to the motility of the colon. More sophisticated technologies now allow scientists to unravel the connections between these alterations and the individual genetic background. This article explores the structural alterations of diverticular disease including collagen, smooth muscle, the enteric nervous system, and the interstitial cells of Cajal.

Keywords

diverticulosis - diverticulitis - elastin - connective tissue - enteric nervous system


Publication History

Article published online:
10 October 2024

© 2024. Thieme. All rights reserved.

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