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CC BY 4.0 · Pharmaceutical Fronts 2024; 06(04): e406-e420
DOI: 10.1055/s-0044-1791542
Review Article

A Review of the Applications of Vitamin C to Treat Human Diseases

Xiaoke He   #
1   Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China
,
Wanting Zhang   #
1   Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China
,
Yonglong He
1   Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China
,
Yuxin Jiang
1   Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China
,
Jiabing Xu   #
2   Department of Traditional Chinese Medicine, Taizhou Institute for Drug Control, Taizhou, People's Republic of China
,
Wei He   #
1   Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China
› Author Affiliations Funding This work was supported by the National Natural Science Foundation of China (Grant No. 81872823 and 82073782).
› Further Information
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Abstract

Vitamin C, a ubiquitous water-soluble vitamin, has been demonstrated to have several biological activities, including the promotion of collagen production, enhancement of immunity, facilitation of iron absorption, and improvement of fat metabolism. Thus, it has a multitude of applications in the medical field, such as whitening, antioxidation, and the prevention of a wide range of diseases. Conversely, its lack of stability and low permeability limit its applicability. This review presents a summary of the physicochemical properties, delivery strategies, and biological activities of vitamin C. Additionally, this review provides an overview of its preventive and therapeutic effects on diseases such as cataracts, tumors, and cardiovascular conditions. Finally, this review explores the prospective applications of vitamin C as a pharmaceutical agent. A variety of vitamin C derivatives and delivery systems have been developed to overcome the instability and low permeability of vitamin C. However, several challenges persist, including the uncertain efficacy of derivatives and the complexities associated with the implementation of delivery systems. It is anticipated that future advancements will facilitate the development of delivery forms and the utilization of vitamin C in novel applications.

Keywords

vitamin C - ascorbic acid - free radicals - antioxidant - biological activities

# These authors contributed equally to this work.




Publication History

Received: 18 September 2023

Accepted: 09 September 2024

Article published online:
21 October 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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