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CC BY-NC-ND 4.0 · International Journal of Practical Otolaryngology 2024; 07(01): e38-e45
DOI: 10.1055/s-0044-1791571
Original Article

Clinical Manifestation of Sensorineural Hearing Loss as an Extraintestinal Complication of Inflammatory Bowel Disease

Moemi Kinoshita
1   Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
,
Takayuki Okano
1   Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
2   Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Fujita Health University, Toyoake, Japan
,
Yosuke Tona
1   Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
,
Hiroshi Yamazaki
1   Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
,
Koichi Omori
1   Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
› Institutsangaben Funding None.
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Abstract

Inflammatory bowel disease (IBD) is an autoimmune condition often accompanied by extraintestinal manifestations including arthritis. However, hearing loss as an extraintestinal manifestation of IBD is rarely reported. This study aimed to investigate the clinical characteristics of sensorineural hearing loss associated with IBD. This study included patients with IBD and hearing loss who were registered between October 2005 and September 2022. The patients were diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) by gastroenterologists in addition to sensorineural hearing loss of unknown etiology confirmed by otolaryngologists. Overall, 32 patients aged 10 to 78 years were included, consisting of 9 women, 18 patients with UC, and 14 patients with CD. Hearing loss associated with IBD was more common among men, with a median onset age of 56 years for UC and 33 years for CD. Two patients reported hearing loss in both ears before IBD onset, whereas 38 ears in 30 patients presented hearing loss after IBD onset. Various types of hearing loss were observed in the 42 affected ears. Further, hearing loss typically developed within 10 years of IBD diagnosis in approximately 63% of cases, with a median interval of 9 years among the 32 cases. In some cases, azathioprine and infliximab, therapeutic agents for IBD, were suspected to have contributed to the hearing loss. No other IBD medications were suspected to contribute to the hearing loss in any patient. The pathogenesis of hearing loss in IBD remains unclear; further large-scale investigations are warranted to elucidate the relationship between IBD and sensorineural hearing loss and to better understand the underlying pathophysiology.

Keywords

inflammatory bowel disease - ulcerative colitis - Crohn's disease - extraintestinal complications - sensorineural hearing loss


Publikationsverlauf

Eingereicht: 11. Dezember 2023

Angenommen: 05. Juli 2024

Artikel online veröffentlicht:
09. Oktober 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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