Download PDF
CC BY 4.0 · Brazilian Journal of Oncology 2024; 20: s00441791656
DOI: 10.1055/s-0044-1791656
Case Report
Clinical Oncology

Primary Mediastinal Large B-cell Lymphoma – A Case Report

Bruno Pelinson Fogaça Duarte 
1   School of Medicine, Universidade Metropolitana de Santos, Santos, SP, Brazil
,
Amanda Scaff Mendes 
1   School of Medicine, Universidade Metropolitana de Santos, Santos, SP, Brazil
,
Ana Clara Parizoti Rossini 
1   School of Medicine, Universidade Metropolitana de Santos, Santos, SP, Brazil
,
José Carlos Medina Carvalho 
2   Department of Hematology and Laboratory Medicine, Universidade Metropolitana de Santos, Santos, SP, Brazil
,
Angelo Sementilli 
3   Department of Pathology , Universidade Metropolitana de Santos, Santos, SP, Brazil
› Author Affiliations Funding The authors declare that they did not receive funding from agencies in the public, private or non-profit sectors to conduct the present study.
› Further Information
   Permissions and Reprints All articles of this category

Abstract

Primary mediastinal large B-cell lymphoma (PMBL) is an uncommon and aggressive subtype of non-Hodgkin large B-cell lymphoma that affects patients in the third and fourth decades of life. The objective of the present report is to describe the case of a male patient admitted to the emergency room with symptoms of dyspnea associated with signs of superior vena cava syndrome. The imaging exams revealed two masses in the mediastinum; the definitive diagnosis, established through an anatomopathological examination and immunohistochemistry, was of PMBL, and the patient was referred for chemotherapy.

Keywords

lymphoma - large B-cell - diffuse - superior vena cava syndrome - neoplasms - case reports

Authors' Contributions

BPFD and ASM: Conception and design and writing of the manuscript; ACPR: Collection and assembly of data and writing of the manuscript; JCMC: Final approval of manuscript and provision of study materials or patient; and AS: Provision of study materials or patient.


Clinical Trials

None.




Publication History

Received: 27 June 2024

Accepted: 28 August 2024

Article published online:
22 October 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

Bibliographical Record
Bruno Pelinson Fogaça Duarte, Amanda Scaff Mendes, Ana Clara Parizoti Rossini, José Carlos Medina Carvalho, Angelo Sementilli. Primary Mediastinal Large B-cell Lymphoma – A Case Report. Brazilian Journal of Oncology 2024; 20: s00441791656.
DOI: 10.1055/s-0044-1791656
 

  • References

  • 1 Savage KJ. Primary mediastinal large B-cell lymphoma. Blood 2022; 140 (09) 955-970
    Search in Google Scholar
  • 2 Cwynarski K, Marzolini MAV, Barrington SF. et al; British Society for Haematology Guidelines. The management of primary mediastinal B-cell lymphoma: a British Society for Haematology Good Practice Paper. Br J Haematol 2019; 185 (03) 402-409
    Search in Google Scholar
  • 3 Alaggio R, Amador C, Anagnostopoulos I. et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia 2022; 36 (07) 1720-1748 PubMed
    Search in Google Scholar
  • 4 Lees C, Keane C, Gandhi MK, Gunawardana J. Biology and therapy of primary mediastinal B-cell lymphoma: current status and future directions. Br J Haematol 2019; 185 (01) 25-41
    Search in Google Scholar
  • 5 Oliveira FAM, Santos ABVD, Brasil SAB. Linfoma Primário De Mediastino: Análise Retrospectiva Dos Fatores Prognósticos E Resposta À Terapia De Primeira Linha Nos Pacientes Da Santa Casa De São Paulo De 2008-2018. Hematol Transfus Cell Ther 2022; 44: S123
    Search in Google Scholar
  • 6 Besteiro B, Teixeira C, Gullo I, Pereira S, Almeida M, Almeida J. Superior vena cava syndrome caused by mediastinal lymphoma: A rare clinical case. Radiol Case Rep 2021; 16 (04) 929-933
    Search in Google Scholar
  • 7 Seligson MT, Surowiec SM. Superior Vena Cava Syndrome. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441981/
    Search in Google Scholar
  • 8 Zhou H, Xu-Monette ZY, Xiao L. et al. Prognostic factors, therapeutic approaches, and distinct immunobiologic features in patients with primary mediastinal large B-cell lymphoma on long-term follow-up. Blood Cancer J 2020; 10 (05) 49
    Search in Google Scholar