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CC BY 4.0 · Arq Neuropsiquiatr 2024; 82(11): s00441791658
DOI: 10.1055/s-0044-1791658
Original Article

Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients

Associação entre a espessura da lâmina cribrosa e o volume do hipocampo em pacientes com doença de Alzheimer
Ersin Kasım Ulusoy 
1   City Hospital of Ankara, Neurology Department, Ankara, Turkey.
,
Döndü Melek Ulusoy 
2   City Hospital of Ankara, Ophthalmology Department, Ankara, Turkey.
,
Mehmet Fatih Göl 
3   City Hospital of Kayseri, Neurology Department, Kayseri, Turkey.
,
Ayşe Çiçek 
4   City Hospital of Kayseri, Ophtalmology Department, Kayseri Turkey.
,
Turgut Tursem Tokmak 
5   City Hospital of Kayseri, Radiology Department, Kayseri, Turkey.
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Abstract

Background Alzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.

Objective To analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).

Methods The sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.

Results The lowest total hippocampal volume (p < 0.05) was in the AD group, which was 6.14 ± 0.66 mm3, while in the control group, it was 7.7 ± 9.65 mm3, and 6.69 ± 0.46 mm3 in the MCI group. In comparison to the rest of the groups, in the AD group, the LCT was the thinnest (202.17 ± 16.35 µm). As per the results of the study population as a whole, low hippocampal volume causes low LCT, which shows an important relationship (r: 0.41; p < 0.05).

Conclusion The current findings present evidence of the relationship between hippocampal volume and LCT in patients with AD and MCI.

Resumo

Antecedentes A doença de Alzheimer (DA) é a causa mais comum de demência e afeta uma grande parcela da população idosa em todo o mundo.

Objetivo Analisar a relação entre a espessura da lâmina cribrosa (ELC) e o volume do hipocampo em pacientes com DA e comprometimento cognitivo leve (CCL).

Métodos A amostra neste estudo consistiu em 20 pacientes com diagnóstico recente de CCL, 20 pacientes com DA recentemente diagnosticados e 20 voluntários saudáveis pareados. Todos os pacientes foram submetidos a exames de ressonância magnética (RM). O programa VolBrain (plataforma de acesso aberto para análise cerebral por RM) foi utilizado para calcular o volume do hipocampo. Tomografia de corrência óptica foi feita para medir a ELC. Os testes análise de variância (ANOVA) e qui-quadrado de Pearson foram empregados para avaliar os resultados.

Resultados O menor volume total do hipocampo (p < 0,05) foi no grupo DA, que foi 6,14 ± 0,66 mm3, enquanto no grupo controle foi 7,7 ± 9,65 mm3 e 6,69 ± 0,46 mm3 no grupo CCL. Em comparação com os demais grupos, no grupo DA, a ELC foi a mais fina (202,17 ± 16,35 µm). De acordo com os resultados da população estudada como um todo, o baixo volume do hipocampo causa baixa ELC, o que mostra uma relação importante (r: 0,41; p < 0,05).

Conclusão Os presentes achados apresentam evidências da relação entre o volume do hipocampo e a ELC em pacientes com DA e CCL.

Keywords

Alzheimer Disease - Hippocampal Volume - Lamina Cribrosa Thickness

Palavras-chave

Doença de Alzheimer - Volume do Hipocampo - Espessura da Lâmina Cribrosa

Authors' Contributions

EKU: investigation, conceptualization, validation, formal analysis, fundraising, data management, methodology, project management, resources, software, monitoring, visualization, and writing – initial design, review & editing; DMU: investigation, resources, software, methodology, validation, and writing – review & editing; MFG: conceptualization, formal analysis, resources, and software; AÇ: resources, conceptualization, software, and formal analysis; TTT: investigation, methodology, resources, software, validation, and writing – review & editing.


Editor-in-Chief: Hélio A. G. Teive.


Associate Editor: Leonardo Cruz de Souza




Publication History

Received: 14 April 2024

Accepted: 30 July 2024

Article published online:
03 November 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

Thieme Revinter Publicações Ltda.
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Bibliographical Record
Ersin Kasım Ulusoy, Döndü Melek Ulusoy, Mehmet Fatih Göl, Ayşe Çiçek, Turgut Tursem Tokmak. Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients. Arq Neuropsiquiatr 2024; 82: s00441791658.
DOI: 10.1055/s-0044-1791658
 

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