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CC BY 4.0 · J Neuroanaesth Crit Care 2024; 11(03): 150-154
DOI: 10.1055/s-0044-1791688
Original Article

Exploring the Association between Allogenic Blood Transfusion and Postoperative Infection Risk Following Intracranial Surgery: A Retrospective Cross-Sectional Analysis

Sakshi Kadian
1   Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Priyanka Gupta 
1   Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
,
Sharmistha Pathak 
2   Department of Anesthesia and Critical Care JPNATC, All India Institute of Medical Sciences, Delhi, India
,
Ashutosh Kaushal
3   Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India
,
Nishant Goyal
4   Department of neurosurgery, All India Institute of medical sciences, Rishikesh, India
,
Siddharth Chakraborty
1   Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
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Abstract

Background Neurosurgical procedures pose a heightened risk of bleeding, often necessitating blood or blood product transfusions. However, allogenic blood transfusion has various adverse consequences, including the transmission of blood-borne infection and immune consequences. While multiple studies have indicated an increased incidence of postoperative infections among patients receiving allogenic blood transfusions, these investigations have primarily focused on non-neurosurgical populations. Therefore, this retrospective study aimed to explore the relationship between blood transfusions and the occurrence of postoperative infections in patients undergoing intracranial surgery for tumors and cerebral aneurysms.

Methods All American Society of Anesthesiologists (ASA) class I to III patients who underwent intracranial surgery (tumors—supratentorial and infratentorial, aneurysm—anterior and posterior circulation) during 3 years (January 2017–December 2020) were included in the study.

Results A total of 240 patients met the inclusion criteria. Perioperative blood transfusion was observed in 103 patients (42.9%). Postoperative infections were observed in 34 patients (14.16%). It was observed that the odds of developing a postoperative infection were 3.37 (p < 0.001) times higher if the patient received a blood transfusion.

Conclusion There exists a robust correlation between perioperative blood transfusion and the subsequent postoperative infection following craniotomy.

Keywords

neurosurgery - blood loss - craniotomy - postoperative infection - allogenic - blood transfusion


Publication History

Article published online:
04 December 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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