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CC BY 4.0 · Pharmaceutical Fronts 2024; 06(04): e382-e393
DOI: 10.1055/s-0044-1792036
Review Article

Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications

Junhua Li
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Yibo Zhou
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Hanqi Zhou
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Fengfan Liu
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
2   Zhejiang Governor Triangle Biomedical Industrial Technology Research Park, Huzhou, People's Republic of China
,
Fuli Zhang
3   Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of China
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Abstract

In the fields of drug synthesis and fine chemicals, the traditional kettle-type reactor with a small heat exchange area and the microreactor which is easy to clog, are not suitable for the reaction with fast reaction speed, large heat release, and high solid content. However, the continuously stirred reactor has the advantages of high mass and heat transfer efficiency, high reaction safety, and not easy to be clogged, and therefore, has a great potential for application. This paper reviews the research progress of continuous agitation reactors in organic synthesis, drug crystallization, and biocatalysis, hoping to provide a reference for applications of continuous agitation reactors in the pharmaceutical and chemical fields.

Keywords

continuous stirred tank reactor - organic synthesis - drug crystallization - biocatalysis


Publication History

Received: 02 February 2024

Accepted: 08 October 2024

Article published online:
20 November 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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