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CC BY 4.0 · World J Nucl Med
DOI: 10.1055/s-0044-1792158
Case Report

Fulminant Heterotopic Ossification following COVID-19 associated Systemic Inflammatory Response Syndrome: Manifestations in Radiology, Nuclear Medicine, and Clinical Application

Deepak P. Kalbi
1   Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, New York, United States
,
Edgar Zamora
1   Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, New York, United States
,
Adithya Hari 
1   Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, New York, United States
,
Kwang J. Chun
1   Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, New York, United States
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Abstract

Heterotopic ossification (HO) is an unclear etiological trigger that results in diverse extra-skeletal bone formation in muscles and soft tissues. This often results in morbidity and reduced quality of life with pain, contractures, and mobility impairment. We present two patients with HO with a history of severe COVID-19 infection requiring 1-month-long mechanical ventilation. The first patient was found to have progressive stiffening of the right knee and left elbow, with clear demonstration of radiographic findings and active dystrophic calcification by nuclear medicine three-phase bone scan. This report might help aid earlier recognition of symptoms for an effective prevention of this debilitating disease. The other patient was also being treated with severe COVID-19, requiring intensive care unit stay with mechanical ventilation demonstrating progressive development of HO on the follow-up computed tomography (CT) images. While abdominal CT studies were obtained for this patient to evaluate the focal sites for infection, the patient was too ill and unable to undergo a bone scan study.

Keywords

heterotopic ossification - joint pain and stiffness - immobility - osteoporosis

Authors' Contributions

All the authors contributed equally to this article.




Publikationsverlauf

Artikel online veröffentlicht:
08. Januar 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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