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Semin Liver Dis 2024; 44(04): 510-522
DOI: 10.1055/s-0044-1795143
Review Article

Role of Complement in Liver Diseases

Luan G. Prado
1   Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio
,
Laura E. Nagy
1   Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio
2   Department of Molecular Medicine, Case Western Reserve University, Cleveland, Ohio
› Institutsangaben Funding This work was supported in part by grants from the National Institutes of Health: P50AA024333 and U01AA026398 (L.E.N.).
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Abstract

This review aims to summarize recent research using animal models, cell models, and human data regarding the role of complement in liver disease. Complement is part of the innate immune system and was initially characterized for its role in control of pathogens. However, evidence now indicates that complement also plays an important role in the response to cellular injury that is independent of pathogens. The liver is the main organ responsible for producing circulating complement. In response to liver injury, complement is activated and likely plays a dual role, both contributing to and protecting from injury. In uncontrolled complement activation, cell injury and liver inflammation occur, contributing to progression of liver disease. Complement activation is implicated in the pathogenesis of multiple liver diseases, including alcohol-associated liver disease, metabolic dysfunction-associated steatotic liver disease, fibrosis and cirrhosis, hepatocellular carcinoma, and autoimmune hepatitis. However, the mechanisms by which complement is overactivated in liver diseases are still being unraveled.

Keywords

alcohol-associated liver disease - metabolic-associated steatotic liver disease - liver fibrosis - cirrhosis


Publikationsverlauf

Artikel online veröffentlicht:
28. November 2024

© 2024. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
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