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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2024; 43(04): e269-e277
DOI: 10.1055/s-0044-1796656
Original Article

Analysis of Biochemical, Hormonal and Radiological Morphological Measurement Values in Patients with Empty Sella: A Clinical Study

Análise de valores de medidas morfológicas bioquímicas, hormonais e radiológicas em pacientes com Sela Vazia: Um estudo clínico
Alemiddin Ozdemir
1   Department of Neurosurgery, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Ahmet Melih Erdogan
1   Department of Neurosurgery, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Ozge Sevimoglu
1   Department of Neurosurgery, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Efe Barıs Durgun
2   School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Suha Alp Ermis
2   School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Rumeysa Yalcin
2   School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Yusuf Emin Karaca
2   School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Sevval Sila Temel
2   School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Sila Gedik
2   School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Ahmet Metehan Albayrak
2   School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Eda Istahlı
3   Department of Radiology, School of Medicine, Kirikkale University, Kirikkale, Turkey
,
Bulent Bakar 
1   Department of Neurosurgery, School of Medicine, Kirikkale University, Kirikkale, Turkey
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Abstract

Objective This study investigated the relationship between radiological morphological findings and hormone levels in patients with empty sella.

Methods Patients (32 female, 3 male) with empty sella detected on radiological images were grouped as “partial empty sella (PBS) group” (subarachnoid space volume < 70%) and “total empty sella (TBS) group” (subarachnoid space volume > 70%). Age, gender, sella volume, pituitary gland thickness, the ratio of subarachnoid space height to pituitary gland height, and diaphragm sellae diameter were measured on radiological images. All patients' blood count results, biochemistry results, and serum hormone values were recorded.

Results Age, complete blood count, serum biochemistry parameters, and hormone levels were not different between PBS and TBS groups. Correlation analysis revealed a negative correlation between gender and subarachnoid space invasion volume, between gender and sagittal width of the sella turcica (ST), between cortisol level and ST axial diameter, between progesterone level and ST axial diameter, between testosterone level and ST axial diameter, between adrenocorticotropic hormone level and ST axial diameter, between TSH level and subarachnoid space invasion rate, between free T4 level and diaphragm sellae sagittal width, and between free T4 level and ST sagittal width.

Conclusion This study showed that some serum hormone values may decrease when the sella tursica dimensions or the volume of subarachnoid space invading the sella tursica increase in patients with empty sella, and therefore, periodic follow-up of hormone levels and radiological images of these patients would be appropriate.

Resumo

Objetivo Este estudo investigou a relação entre achados morfológicos radiológicos e níveis hormonais em pacientes com sela vazia.

Métodos Pacientes (32 mulheres 3 homens) com sela vazia detectada em imagens radiológicas foram agrupados como “grupo sela parcialmente vazia (PBS)” (volume do espaço subaracnóideo < 70%) e “grupo sela totalmente vazia (TBS)” (volume do espaço subaracnóideo > 70%). Idade sexo volume da sela espessura da glândula pituitária a razão entre a altura do espaço subaracnóideo e a altura da glândula pituitária e o diâmetro do diafragma da sela foram medidos em imagens radiológicas. Os resultados do hemograma bioquímica e valores hormonais séricos de todos os pacientes foram registrados.

Resultados Idade hemograma completo parâmetros bioquímicos séricos e níveis hormonais não foram diferentes entre os grupos PBS e TBS. A análise de correlação revelou uma correlação negativa entre gênero e volume de invasão do espaço subaracnóideo entre gênero e largura sagital da sela túrcica (ST) entre nível de cortisol e diâmetro axial do ST entre nível de progesterona e diâmetro axial do ST entre nível de testosterona e diâmetro axial do ST entre nível de hormônio adrenocorticotrófico e diâmetro axial do ST entre nível de TSH e taxa de invasão do espaço subaracnóideo entre nível de T4 livre e largura sagital do diafragma da sela e entre nível de T4 livre e largura sagital do ST.

Conclusão Este estudo mostrou que alguns valores hormonais séricos podem diminuir quando as dimensões da sela túrsica ou o volume do espaço subaracnóideo que invade a sela túrsica aumentam em pacientes com sela vazia e portanto o acompanhamento periódico dos níveis hormonais e imagens radiológicas desses pacientes seria apropriado.

Keywords

Empty Sella - radiology - morphology - hormone - biochemistry

Palavras-chave

Sela Vazia - radiologia - morfologia - hormônio - bioquímica

The abstract of this article was accepted as oral presentation number “SS-092” at the 37th Scientific Congress of the Turkish Neurosurgical Society held between April 18-21, 2024.




Publication History

Received: 20 April 2024

Accepted: 18 October 2024

Article published online:
11 December 2024

© 2024. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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