Abstract
Objectives This study aimed to evaluate collagen fiber deposition and callus formation on geopolymer-carbonated
hydroxyapatite (CHA) nanocomposites-doped with magnesium (Mg) and strontium (Sr) on
days 14 and 28 in the tibia of New Zealand rabbits.
Materials and Methods Geopolymer-CHA-Mg-Sr nanocomposite samples with a diameter of 3 mm and a height of
6 mm were placed in the tibia of eight New Zealand rabbits. Experimental subjects
were randomly divided into two groups to evaluate collagen fiber deposition and callus
formation on days 14 and 28 histomorphologically.
Statistical Analysis T -test was performed, and p < 0.05 was considered statistically significant using Minitab version 13.
Results There was no significant difference in collagen deposition and callus formation on
the geopolymer-CHA-Mg-Sr surface on days 14 and 28 with p -values 0.075 and 0.842, respectively.
Conclusion Geopolymer-CHA-Mg-Sr is biocompatible, bioinert, and osteoconductive, and its mechanical
properties meet the dentin standard values for hardness, while the modulus of elasticity,
compressive, and tensile strength meets the enamel standard values.
Keywords collagen fiber deposition - callus - geopolymer-CHA-Mg-Sr - Masson's trichrome
