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CC BY 4.0 · Brazilian Journal of Oncology 2025; 21: s00441800924
DOI: 10.1055/s-0044-1800924
Original Article
Surgical Oncology

Is the Pressure from Blue Dye Cervical Injection Associated with Sentinel Lymph Node Detection in Laparoscopic Surgery for Endometrial Cancer?

Authors

  • Marcelo Simonsen 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil
    2   Department of Radiology and Oncology, Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brazil

  • Marina Bandeira de Mello Amaral 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil

  • Najla Mohamed Tayfour 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil

  • Eric Vieira Luna Mayerhoff 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil

  • Igor Marcondes de Andrade 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil

  • Lais Moreira Silva 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil

  • Marcelo Antonini 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil

  • Andressa Melina Severino Teixeira 

    1   Gynecology and Obstetrics Department, Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil

Funding The authors declare that they did not receive financial support from agencies in the public, private, or non-profit sectors to conduct the present study. Clinical Trials None.
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Abstract

Introduction Sentinel lymph node biopsy (SLNB) has been proven to be a safe procedure in the treatment of endometrial cancer, and the instillment of a dye/marker in the cervix is the most used technique. Various studies have correlated the body mass index (BMI) impact as well as menopausal status and staging with the rate of lymph node detection, but few studies have evaluated if the high density of the cervix decreases detection.

Objective To quantify the injection pressure of the marker in the uterine cervix and to correlate it with the sentinel lymph node detection rate in endometrial neoplasia.

Materials and Methods Patients with endometrial cancer with programmed laparoscopic SLNB were selected to have the cervical injection pressure assessed. Immediately following the extraction of the uterus, saline solution was reapplied to measure injection pressure with a device attached to the syringe. We investigated the possible correlation of injection pressure with lymph node detection rate and the clinical data of the patients.

Results A total of 18 women participated in the study; a correlation between injection pressure and lymph node detection rate was not identified, neither was greater injection pressure detected in smaller uteruses or cervices. The pressure of the deep injection is greater than that of the superficial one, but the more medial application, or more lateral in relation to the midpoint, does not alter the injection pressure.

Conclusion The presence of greater resistance in the instillment of stain into the cervix was not associated with a lower lymph node detection rate.

Keywords

sentinel lymph node dissection - endometrial cancer - detection rate

Authors' Contributions

MS: collection and assembly of data, conception and design, data analysis and interpretation, final approval of the manuscript, writing of the manuscript, and provision of study materials or patient; MBMA: collection and assembly of data, conception and design, and writing of the manuscript; NT: conception and design and final approval of the manuscript; EVLLM: data analysis and interpretation, and provision of study materials or patient; IMA: collection and assembly of data and data analysis and interpretation; LM: collection and assembly of data, conception and design, and final approval of the manuscript; MA: final approval of the manuscript; AMST: conception and design, final approval of the manuscript, and provision of study materials or patient.


Supplementary Material



Publication History

Received: 28 August 2024

Accepted: 30 September 2024

Article published online:
29 January 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Marcelo Simonsen, Marina Bandeira de Mello Amaral, Najla Mohamed Tayfour, Eric Vieira Luna Mayerhoff, Igor Marcondes de Andrade, Lais Moreira Silva, Marcelo Antonini, Andressa Melina Severino Teixeira. Is the Pressure from Blue Dye Cervical Injection Associated with Sentinel Lymph Node Detection in Laparoscopic Surgery for Endometrial Cancer?. Brazilian Journal of Oncology 2025; 21: s00441800924.
DOI: 10.1055/s-0044-1800924
 

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