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CC BY 4.0 · Revista Brasileira de Cirurgia Plástica (RBCP) – Brazilian Journal of Plastic Surgery 2024; 39(04): s00441801341
DOI: 10.1055/s-0044-1801341
Ideias e Inovações

Applications of Biotissues in Plastic Surgery: A Systematic Review

Article in several languages: português | English
Rafael Silva de Araújo 
1   Departamento de Cirurgia Plástica, Universidade Federal de São Paulo, São Paulo, SP, Brasil
,
Matheus Galvão Valadares Bertolini Mussalem 
1   Departamento de Cirurgia Plástica, Universidade Federal de São Paulo, São Paulo, SP, Brasil
,
Nicole Tortoro Silva 
2   Departamento de Medicina, Faculadade de Medicina de Sorocaba, Sorocaba, SP, Brasil
,
Elvio Bueno Garcia 
1   Departamento de Cirurgia Plástica, Universidade Federal de São Paulo, São Paulo, SP, Brasil
,
Lydia Masako Ferreira 
1   Departamento de Cirurgia Plástica, Universidade Federal de São Paulo, São Paulo, SP, Brasil
› Author Affiliations Financial Support The authors declare that they did not receive financial support from agencies in the public, private, or non-profit sectors to conduct the present study.

Ensaios Clínicos Não. | Clinical Trials None.
› Further Information
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Abstract

Introduction Biotissues are defined as organized combinations of synthetic and/or biological substances that interact with complex biological systems to treat, replace, or remodel tissues and organs. Tissue bioengineering employs a variety of methods, including the use of biological and synthetic scaffolds, along with interactions involving stem cells and cytokines. The present review evaluates the techniques and methods for biotissue synthesis, as well as their efficacy in both animal and human models.

Materials and Methods A systematic literature review was conducted using the PubMed, Lilacs, Scielo, and Cochrane databases, employing specific descriptors. The analysis focused on identifying the countries of origin of the studies and categorizing the techniques and resources utilized, with the aim of informing the selection of strategies for the application of biotissues in reconstructive plastic surgery.

Results Among the 37 selected articles, 15 focused on in vitro experimentation, 14 on in vivo experimentation, and 8 employed both approaches. The studies were further categorized into 3 primary subtopics: adipogenesis (18 articles), angiogenesis (10 articles), and chondrogenesis (9 articles), all relevant to tissue reconstruction.

Conclusion Advances in the use of biomaterials in regenerative medicine are promising, with experimental results aligning well with contemporary plastic surgery practices. While human application remains limited, the potential of stem cells and growth factors suggests significant future developments, warranting further focused studies. The present review elucidates the technologies and progress in the use of biomaterials, highlighting their impact on the technical evolution of reconstructive plastic surgery.

Keywords

biomaterials - reconstructive plastic surgery - scaffolds

Authors' Contributions

RSA: analysis and/or data interpretation, conception and design study, conceptualization, data curation, final manuscript approval, formal analysis, funding acquisition, investigation, methodology, project administration, resources, supervision, validation, visualization, writing—original draft preparation, and Writing—review & editing; MGVBM: analysis and/or data interpretation, conceptualization, data curation, formal analysis, methodology, and writing—original draft preparation; NTS: analysis and/or data interpretation, conception and design study, conceptualization, formal analysis, investigation, project administration, resources, validation, and writing—original draft preparation; EBG: supervision, visualization, and writing—review & editing; LMF: Conception and design study, supervision, validation, visualization, writing—review & editing.


Ethics Committee

CEUA UNIFESP Nr. 1966101023.




Publication History

Received: 09 October 2023

Accepted: 29 September 2024

Article published online:
27 January 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Rafael Silva de Araújo, Matheus Galvão Valadares Bertolini Mussalem, Nicole Tortoro Silva, Elvio Bueno Garcia, Lydia Masako Ferreira. Aplicações dos biotecidos na cirurgia plástica: Uma revisão sistemática. Revista Brasileira de Cirurgia Plástica (RBCP) – Brazilian Journal of Plastic Surgery 2024; 39: s00441801341.
DOI: 10.1055/s-0044-1801341
 

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