Download PDF
CC BY 4.0 · World J Nucl Med
DOI: 10.1055/s-0044-1801385
Case Report

A Rare Case of Cystic Angiomatosis Involving the Bones: Our Experience and Review of Literature

Priyatesh Chandra Dwivedi
1   Department of Hematology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
,
Chaitanya Borde
2   Department of Nuclear Medicine, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
,
Ramesh Venkata Yasam
3   Department of Academics, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
,
Raj Nagarkar
4   Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India
› Author Affiliations
› Further Information
Also available at
   Permissions and Reprints

Abstract

Cystic angiomatosis (CA) is a rare, benign, multifocal disorder of mixed lesions (lytic, sclerotic) developed due to maldeveloped lymphatic and vascular systems. In majority of cases, it is identified fortuitously and mimicked as metastatic malignant lesions. In such cases, differential diagnosis followed by treatment is identified to be critical for stabilizing the disease and its prognosis. We reported a case of a 24-year-old female who presented to our center with complaints of lower back ache (∼4–6 weeks), intermittent pain in the abdomen, and occasional dyspnea on exertion. Imaging studies revealed mild lytic lesions and small-sized cysts in the spine, bones, and spleen. Investigations confirmed CA and follow-up treatment was given using zoledronic acid (4 mg/intravenous) every 3 months to stabilize the bone lesions. CA is a heterogeneous disease with unpredictable progression and uncertain treatment. So, it is highly recommended to disseminate research findings of all such rare cases to find any new pathophysiological findings and establish an effective treatment.

Keywords

cystic angiomatosis - metastatic malignant lesions - bone lesions - PET-CT - case report

Authors' Contributions

Concept: P.C.D.; design: P.C.D., Y.V.R.; supervision: P.C.D., R.N.; materials: P.C.D., C.B., R.N.; data collection and/or processing: P.C.D., C.B., Y.V.R.; analysis and/or interpretation: P.C.D., C.B., Y.V.R., R.N.; literature search: Y.V.R.; writing manuscript: Y.V.R.; critical review: P.C.D.




Publication History

Article published online:
09 January 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Iranpour P, Namdari N, Alavi M, Geramizadeh B. Systemic cystic angiomatosis mimicking metastatic cancer. Curr Probl Cancer 2022; 46 (01) 100763
    CrossrefPubMedSearch in Google Scholar
  • 2 Kumar V, Meghal T, Sun YH, Huang Y. Systemic cystic angiomatosis mimicking metastatic cancer: a case report and review of the literature. Case Rep Med 2017; 2017: 5032630
    CrossrefPubMedSearch in Google Scholar
  • 3 Dos Anjos CS, Borges RMC, Chaves AC, Fuzita WH, Silva CAM, de Oliveira UGL. Cystic angiomatosis, pleural effusion and multiple bone lesions mimicking a metastatic malignant neoplasia: a case report. J Med Case Rep 2019; 13 (01) 265
    CrossrefPubMedSearch in Google Scholar
  • 4 Najm A, Soltner-Neel E, Le Goff B, Guillot P, Maugars Y, Berthelot JM. Cystic angiomatosis, a heterogeneous condition: four new cases and a literature review. Medicine (Baltimore) 2016; 95 (43) e5213
    CrossrefPubMedSearch in Google Scholar
  • 5 Parsons LG, Ebbs JH. Generalized angiomatosis presenting the clinical characteristics of storage reticulosis: with some observations on the reticulo-endothelioses. Arch Dis Child 1940; 15 (83) 129-158
    CrossrefPubMedSearch in Google Scholar
  • 6 Jacobs JE, Kimmelstiel P. Cystic angiomatosis of the skeletal system. J Bone Joint Surg Am 1953; 35-A (02) 409-420
    CrossrefPubMedSearch in Google Scholar
  • 7 Sawalgi V, Amin D, Arora AJ, Srivastava M, Uppin M. A rare case of systemic cystic angiomatosis involving the bones, spleen, liver, and lungs. Cureus 2022; 14 (10) e30414
    PubMedSearch in Google Scholar
  • 8 Li WC, Liu L, Wang ZD, Chen H, Liu G, Feng ZC. Cystic angiomatosis in children: clinical experience and review of literature. World J Surg Oncol 2022; 20 (01) 390
    CrossrefPubMedSearch in Google Scholar
  • 9 Marcucci G, Masi L, Carossino AM. et al. Cystic bone angiomatosis: a case report treated with aminobisphosphonates and review of the literature. Calcif Tissue Int 2013; 93 (05) 462-471
    CrossrefPubMedSearch in Google Scholar